Reposted by Alessandro Lussana
Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (@alussana.bsky.social).
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
October 21, 2025 at 12:58 PM
Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (@alussana.bsky.social).
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Reposted by Alessandro Lussana
Exciting opportunity at the forefront of network biology, multiomics, AI and DT. Deadline 13th July! embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Postdoctoral Fellow – Bioinformatics & Executable Modelling for Rare Disease Digital Twins
We are looking for a motivated and talented postdoctoral-level researcher with experience in executable modelling to join a cutting-edge project developing Digital Twins for rare diseases. This is a u...
embl.wd103.myworkdayjobs.com
June 13, 2025 at 3:45 PM
Exciting opportunity at the forefront of network biology, multiomics, AI and DT. Deadline 13th July! embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Reposted by Alessandro Lussana
I, Rahuman Sheriff @biomodels.bsky.social and Ellie McDonagh from @opentargets.org @ebi.embl.org are looking for an enthusiastic postdoc with skills in executable modelling to create Digital Twins for rare disease (CZI-funded project).
Postdoctoral Fellow – Bioinformatics & Executable Modelling for Rare Disease Digital Twins
We are looking for a motivated and talented postdoctoral-level researcher with experience in executable modelling to join a cutting-edge project developing Digital Twins for rare diseases. This is a u...
embl.wd103.myworkdayjobs.com
June 13, 2025 at 3:45 PM
I, Rahuman Sheriff @biomodels.bsky.social and Ellie McDonagh from @opentargets.org @ebi.embl.org are looking for an enthusiastic postdoc with skills in executable modelling to create Digital Twins for rare disease (CZI-funded project).
Reposted by Alessandro Lussana
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
May 23, 2025 at 7:38 AM
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
Reposted by Alessandro Lussana
We present SELPHI 2.0 a machine learning model integrating >40 sequence, omics and structural features to predict kinase-substrate interactions between 420 kinases and 240K phosphosites and improve interpretation of global phosphoproteomics data www.sciencedirect.com/science/arti...
Data-driven extraction of human kinase-substrate relationships from omics datasets
Phosphorylation forms an important part of the signalling system that cells use for decision making and regulation of processes such as cell division …
www.sciencedirect.com
May 16, 2025 at 9:09 AM
We present SELPHI 2.0 a machine learning model integrating >40 sequence, omics and structural features to predict kinase-substrate interactions between 420 kinases and 240K phosphosites and improve interpretation of global phosphoproteomics data www.sciencedirect.com/science/arti...
Reposted by Alessandro Lussana
Kinases play a role in many diseases, making them prime targets for therapeutic intervention.
Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.
Read the full article: academic.oup.com/bioinformati...
@alussana.bsky.social @epetsalaki.bsky.social
Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.
Read the full article: academic.oup.com/bioinformati...
@alussana.bsky.social @epetsalaki.bsky.social
PhosX: data-driven kinase activity inference from phosphoproteomics experiments
AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru
academic.oup.com
January 27, 2025 at 11:57 AM
Kinases play a role in many diseases, making them prime targets for therapeutic intervention.
Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.
Read the full article: academic.oup.com/bioinformati...
@alussana.bsky.social @epetsalaki.bsky.social
Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.
Read the full article: academic.oup.com/bioinformati...
@alussana.bsky.social @epetsalaki.bsky.social
Reposted by Alessandro Lussana
Update: Since we published "Cracking the black box of deep sequence-based protein-protein interaction prediction," we have received mostly positive feedback. I presented our work at multiple conferences, including the ISMB/ECCB23 and GCB23. 🧬🖥️
doi.org/10.1093/bib/...
doi.org/10.1093/bib/...
Cracking the black box of deep sequence-based protein–protein interaction prediction
Abstract. Identifying protein–protein interactions (PPIs) is crucial for deciphering biological pathways. Numerous prediction methods have been developed a
academic.oup.com
November 28, 2024 at 9:23 AM
Update: Since we published "Cracking the black box of deep sequence-based protein-protein interaction prediction," we have received mostly positive feedback. I presented our work at multiple conferences, including the ISMB/ECCB23 and GCB23. 🧬🖥️
doi.org/10.1093/bib/...
doi.org/10.1093/bib/...
Reposted by Alessandro Lussana
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!
November 21, 2024 at 6:33 AM
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!