Anna-Lena Neehus
@alneehus.bsky.social
Postdoctoral Fellow | Sankaran Lab | Boston Children's Hospital | Immunologist studying human genetics
Reposted by Anna-Lena Neehus
Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology:
rupress.org/jhi
rupress.org/jhi
Journal of Human Immunity | Rockefeller University Press
Journal of Human Immunity (JHI) publishes papers that provide novel insights into the physiology and pathology of human immunity through the study of genetic defects and their phenocopies, including t...
rupress.org
October 31, 2025 at 2:58 PM
Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology:
rupress.org/jhi
rupress.org/jhi
Reposted by Anna-Lena Neehus
Human genetic influences on early B cell development. New review from Anna-Lena Neehus (@alneehus.bsky.social), Neil Romberg (@romberglab.bsky.social), and Vijay Sankaran (@bloodgenes.bsky.social) @bostonchildrens.bsky.social: rupress.org/jhi/article/...
July 2, 2025 at 3:10 PM
Human genetic influences on early B cell development. New review from Anna-Lena Neehus (@alneehus.bsky.social), Neil Romberg (@romberglab.bsky.social), and Vijay Sankaran (@bloodgenes.bsky.social) @bostonchildrens.bsky.social: rupress.org/jhi/article/...
Reposted by Anna-Lena Neehus
@alneehus.bsky.social, @romberglab.bsky.social and @bloodgenes.bsky.social review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...
June 26, 2025 at 1:14 PM
@alneehus.bsky.social, @romberglab.bsky.social and @bloodgenes.bsky.social review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...
Reposted by Anna-Lena Neehus
A must-read for anyone interested in human B cell physiology or pathology !
.@alneehus.bsky.social, @romberglab.bsky.social and @bloodgenes.bsky.social review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...
June 25, 2025 at 4:44 PM
A must-read for anyone interested in human B cell physiology or pathology !
Reposted by Anna-Lena Neehus
Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...
June 4, 2025 at 1:59 AM
Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...
Reposted by Anna-Lena Neehus
📢📢Published today in @jem.org 📢📢
New human inborn error of immunity.
We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.
rupress.org/jem/article/...
@ubcmedicine.bsky.social @bcchresearch.bsky.social
New human inborn error of immunity.
We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.
rupress.org/jem/article/...
@ubcmedicine.bsky.social @bcchresearch.bsky.social
May 20, 2025 at 4:43 PM
📢📢Published today in @jem.org 📢📢
New human inborn error of immunity.
We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.
rupress.org/jem/article/...
@ubcmedicine.bsky.social @bcchresearch.bsky.social
New human inborn error of immunity.
We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.
rupress.org/jem/article/...
@ubcmedicine.bsky.social @bcchresearch.bsky.social
Reposted by Anna-Lena Neehus
Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains @jem.org @casanovalab.bsky.social rupress.org/jem/article/...
April 15, 2025 at 2:46 AM
Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains @jem.org @casanovalab.bsky.social rupress.org/jem/article/...
Reposted by Anna-Lena Neehus
Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes
Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...
bit.ly
April 3, 2025 at 9:20 PM
Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
Reposted by Anna-Lena Neehus
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
March 27, 2025 at 8:31 PM
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Reposted by Anna-Lena Neehus
1/ Our next stellar lab alumnus is @jonathanbohlen.bsky.social - a molecular biologist and a postdoc in our Paris lab from 2021-24 who is now a research group leader at the Gene Center at @lmumuenchen.bsky.social
www.genzentrum.uni-muenchen.de/index.html
www.genzentrum.uni-muenchen.de/index.html
March 25, 2025 at 3:26 PM
1/ Our next stellar lab alumnus is @jonathanbohlen.bsky.social - a molecular biologist and a postdoc in our Paris lab from 2021-24 who is now a research group leader at the Gene Center at @lmumuenchen.bsky.social
www.genzentrum.uni-muenchen.de/index.html
www.genzentrum.uni-muenchen.de/index.html
Reposted by Anna-Lena Neehus
Fantastic to write this Spotlight piece for @cp-trendsmolecmed.bsky.social with @sshelton.bsky.social that covers an exciting recent @nejm.org study (www.nejm.org/doi/full/10....):
authors.elsevier.com/a/1koWQ5Eb1B...
authors.elsevier.com/a/1koWQ5Eb1B...
March 24, 2025 at 1:59 PM
Fantastic to write this Spotlight piece for @cp-trendsmolecmed.bsky.social with @sshelton.bsky.social that covers an exciting recent @nejm.org study (www.nejm.org/doi/full/10....):
authors.elsevier.com/a/1koWQ5Eb1B...
authors.elsevier.com/a/1koWQ5Eb1B...
Reposted by Anna-Lena Neehus
Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess
#OpenAccess
February 26, 2025 at 5:15 PM
Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess
#OpenAccess
Reposted by Anna-Lena Neehus
🧬 Join Institut Imagine as a Junior Group Leader!
- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine
To submit your application : lnkd.in/enm-U2tH
- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine
To submit your application : lnkd.in/enm-U2tH
January 24, 2025 at 1:09 PM
🧬 Join Institut Imagine as a Junior Group Leader!
- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine
To submit your application : lnkd.in/enm-U2tH
- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine
To submit your application : lnkd.in/enm-U2tH
Reposted by Anna-Lena Neehus
I am incredibly fortunate to be able to work with this amazing group @hhmi.bsky.social, @bostonchildrens.bsky.social, @danafarber.bsky.social, @harvardmed.bsky.social, @broadinstitute.org!!! 🙏🩸🧬
January 24, 2025 at 2:17 PM
I am incredibly fortunate to be able to work with this amazing group @hhmi.bsky.social, @bostonchildrens.bsky.social, @danafarber.bsky.social, @harvardmed.bsky.social, @broadinstitute.org!!! 🙏🩸🧬
Reposted by Anna-Lena Neehus
Excited to launch this new journal with a great team, and the support of both RUP and IAPIDS, and the entire community of human inborn errors of immunity !
Welcome to the future of #HumanImmunity research! @rupress.org and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 https://buff.ly/4ajqm8W
January 16, 2025 at 5:09 PM
Excited to launch this new journal with a great team, and the support of both RUP and IAPIDS, and the entire community of human inborn errors of immunity !
Reposted by Anna-Lena Neehus
The 2024 IUIS Inborn Errors of Immunity (IEI) Classification has arrived! Explore our latest insights now at www.iuis.org/committees/iei (link in bio). Find the report under “Annual 2024 Report”!
January 9, 2025 at 12:44 PM
The 2024 IUIS Inborn Errors of Immunity (IEI) Classification has arrived! Explore our latest insights now at www.iuis.org/committees/iei (link in bio). Find the report under “Annual 2024 Report”!
Reposted by Anna-Lena Neehus
#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging.
www.science.org
January 4, 2025 at 2:51 PM
#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation
Reposted by Anna-Lena Neehus
Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 2, 2025 at 2:47 PM
Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anna-Lena Neehus
Delighted to have our work led by #RichardVoit
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:
www.cell.com/cell-stem-ce...
Stay tuned as we work on initiating a clinical trial for this approach!
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:
www.cell.com/cell-stem-ce...
Stay tuned as we work on initiating a clinical trial for this approach!
January 2, 2025 at 4:01 PM
Delighted to have our work led by #RichardVoit
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:
www.cell.com/cell-stem-ce...
Stay tuned as we work on initiating a clinical trial for this approach!
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:
www.cell.com/cell-stem-ce...
Stay tuned as we work on initiating a clinical trial for this approach!
Reposted by Anna-Lena Neehus
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.
www.cuimc.columbia.edu
January 1, 2025 at 5:45 PM
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼