Alice Perucca
@aliperri.bsky.social
Biologist working in (cancer) mechanobiology - PhD student @ibecbarcelona.eu in Integrative Cell and Tissue Dynamics group
Alumni @utrechtuniversity.bsky.social
Alumni @utrechtuniversity.bsky.social
7/7 Friends 🎈 I am incredibly grateful to have worked alongside my wonderful co-first author, @oriolmb.bsky.social. This project has been a surprising journey, filled with challenges, triumphs, and lots of laughs. Cheers to the friendships made through science!
February 10, 2025 at 4:42 PM
7/7 Friends 🎈 I am incredibly grateful to have worked alongside my wonderful co-first author, @oriolmb.bsky.social. This project has been a surprising journey, filled with challenges, triumphs, and lots of laughs. Cheers to the friendships made through science!
6/7: Thanks! This work wouldn't have been possible without the contributions of co-authors: @oriolmb.bsky.social Andrea Gomez and all the authors: Alex Calon, Anna Labernadie @challopeau.bsky.social et al. Special thanks to @xaviertrepat.bsky.social for the opportunity to take part in this project.
February 10, 2025 at 4:42 PM
6/7: Thanks! This work wouldn't have been possible without the contributions of co-authors: @oriolmb.bsky.social Andrea Gomez and all the authors: Alex Calon, Anna Labernadie @challopeau.bsky.social et al. Special thanks to @xaviertrepat.bsky.social for the opportunity to take part in this project.
5/7: Impact. MIRO offers a valuable ex vivo platform that helps uncover mechanisms of immune exclusion potentially accelerating drug development, bridging the gap from lab to clinic 💊, ultimately improving patient outcomes. #TranslationalResearch
February 10, 2025 at 4:42 PM
5/7: Impact. MIRO offers a valuable ex vivo platform that helps uncover mechanisms of immune exclusion potentially accelerating drug development, bridging the gap from lab to clinic 💊, ultimately improving patient outcomes. #TranslationalResearch
4/7: MIRO enables high throughput testing of #immunotherapies, opening new possibilities for personalized cancer treatments.
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment
February 10, 2025 at 4:42 PM
4/7: MIRO enables high throughput testing of #immunotherapies, opening new possibilities for personalized cancer treatments.
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment
3/7: Why MIRO is unique?
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem
February 10, 2025 at 4:42 PM
3/7: Why MIRO is unique?
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem
2/7: MIRO is an open fluidic device that models the tumour-stroma interface using patient-derived cells. This allows us to recreate aspects of the #TumorMicroenvironment and study immune cell interactions in the lab. 🔎🧫 #Microfluidics #OnChip
February 10, 2025 at 4:42 PM
2/7: MIRO is an open fluidic device that models the tumour-stroma interface using patient-derived cells. This allows us to recreate aspects of the #TumorMicroenvironment and study immune cell interactions in the lab. 🔎🧫 #Microfluidics #OnChip
Reposted by Alice Perucca
Work conceived by Anna Labernadie during her postdoc in the lab—now running her group at CIPF—in collaboration with Alex Calon from @researchmar.bsky.social. Congrats to first authors @aliperri.bsky.social , Andrea Gómez and @oriolmb.bsky.social ! ibecbarcelona.eu/researchers-...
Researchers develop a device that replicates tumours to study the efficacy of immunotherapy treatments
The Micro Immune Response On chip (MIRO) allows tumours and their environment to be replicated in order to understand their response to immunotherapy-based treatments.
ibecbarcelona.eu
February 7, 2025 at 11:46 AM
Work conceived by Anna Labernadie during her postdoc in the lab—now running her group at CIPF—in collaboration with Alex Calon from @researchmar.bsky.social. Congrats to first authors @aliperri.bsky.social , Andrea Gómez and @oriolmb.bsky.social ! ibecbarcelona.eu/researchers-...