Alexander Stein
alexsteinresearch.bsky.social
Alexander Stein
@alexsteinresearch.bsky.social
96 followers 210 following 3 posts
Cancer Genomics | Somatic Evolution | Math Bio DE -> CH -> UK -> BE Always happy to chat about science!
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Interested in population genetics of cancer?

If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:

academic.oup.com/genetics/adv...

We build on and expand the population genetics theory of gITH.

Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
Reposted by Alexander Stein
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?

Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Alexander Stein
Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
Reposted by Alexander Stein
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
Reposted by Alexander Stein
Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. https://www.biorxiv.org/content/10.1101/2025.09.08.674950v1
Reposted by Alexander Stein
New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.

Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14

arxiv.org/abs/2507.08615
Reposted by Alexander Stein
In #GENETICS, @alexsteinresearch.bsky.social‬ and @benjaminwerner.bsky.social‬ present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/AE4sLUH
Interested in population genetics of cancer?

If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:

academic.oup.com/genetics/adv...

We build on and expand the population genetics theory of gITH.

Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
Reposted by Alexander Stein
My department is hiring! Permanent faculty job (research + teaching) in applied maths. Mathematical biology would be highly appropriate. We're a friendly department in a large university in central London, recently merged with a big medical school. Apply by 1st June. www.jobs.ac.uk/job/DMY889/l...
Lecturer in Applied Mathematics at City St George’s, University of London
Apply for the Lecturer in Applied Mathematics role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
Thank you David @cancerevo.org and Simone @zaccasimo.bsky.social for building my PhD viva panel! I enjoyed the discussions and appreciate your time and effort to assess my PhD.

And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!
Congrats Dr. @alexsteinresearch.bsky.social and also Alex's PhD supervisor @benjaminwerner.bsky.social for an excellent body of doctoral work pushing the frontiers of #mathonco and #cancerevo
Reposted by Alexander Stein
Congratulations to a successful viva Dr. @alexsteinresearch.bsky.social

Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!
Congrats to all of you! 🥳
Reposted by Alexander Stein
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
www.findaphd.com
Reposted by Alexander Stein
📝New Author's summary about

"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak

and

"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak
Reposted by Alexander Stein
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
www.medrxiv.org