Alex Chang, MD
@alexchangmd.bsky.social
Associate professor, clinician-scientist/dad/husband interested in early prevention/treatment of kidney disease
tweets=personal views #nephsky
tweets=personal views #nephsky
ABIM LKM chatGPT?
November 13, 2025 at 6:00 PM
ABIM LKM chatGPT?
Excellent talk by Emmanuel Letavernier on iatrogenic/environmental causes of kidney stones. Vitamin C supplementation during COVID pandemic, vitamin D supplementation possible risk factor for Randalls plaques, hair straightening products glyoxylic acid and galore #kidneywk
November 8, 2025 at 3:58 AM
Excellent talk by Emmanuel Letavernier on iatrogenic/environmental causes of kidney stones. Vitamin C supplementation during COVID pandemic, vitamin D supplementation possible risk factor for Randalls plaques, hair straightening products glyoxylic acid and galore #kidneywk
Cool article on potential of exon skipping therapies for rare genetic kidney diseases like x-linked Alport syndrome. Uses anti-sense oligonucleotides (ASOs). This type of treatment has been in use for in Duchenne muscular dystrophy journals.lww.com/jasn/pages/a...
November 7, 2025 at 12:55 PM
Cool article on potential of exon skipping therapies for rare genetic kidney diseases like x-linked Alport syndrome. Uses anti-sense oligonucleotides (ASOs). This type of treatment has been in use for in Duchenne muscular dystrophy journals.lww.com/jasn/pages/a...
Looking for new research opportunities in this challenging environment? Consider joining our Center for Kidney Health Research, pt centered research program in a learning health system, leveraging EHR since 1996, exome sequencing in the MyCode cohort. #kidneywk
jobs.geisinger.org/job/danville...
jobs.geisinger.org/job/danville...
November 6, 2025 at 6:19 PM
Looking for new research opportunities in this challenging environment? Consider joining our Center for Kidney Health Research, pt centered research program in a learning health system, leveraging EHR since 1996, exome sequencing in the MyCode cohort. #kidneywk
jobs.geisinger.org/job/danville...
jobs.geisinger.org/job/danville...
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
November 1, 2025 at 7:53 PM
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
I like to keep tabs on what quackery my patients might be reading so I am subscribed to Peter McCullough ™. Looks like I can get a detox of the covid vaccine I got yesterday with some nattokinase/bromelain/curcumin and dandelion oil concoction
October 22, 2025 at 11:08 AM
I like to keep tabs on what quackery my patients might be reading so I am subscribed to Peter McCullough ™. Looks like I can get a detox of the covid vaccine I got yesterday with some nattokinase/bromelain/curcumin and dandelion oil concoction
Great BP study in VA by Holly Kramer et al showing terminal digit preference (TDP) to “0” and “8” - particularly in those with BP <140/90 (I.e. wishful thinking/recording?). More TDP ( sloppy BP measurement) correlates w/better BP control rates!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
October 9, 2025 at 1:04 AM
Great BP study in VA by Holly Kramer et al showing terminal digit preference (TDP) to “0” and “8” - particularly in those with BP <140/90 (I.e. wishful thinking/recording?). More TDP ( sloppy BP measurement) correlates w/better BP control rates!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
I was just asked to evaluate AI-generated educational questions for providers (created by non-specialists for 'educational purposes'), riddled with/nonsensical issues as one might expect but looks possibly professional. Then I asked another AI to spot issues. Obviously, I think this is dumb...!
October 2, 2025 at 1:38 PM
I was just asked to evaluate AI-generated educational questions for providers (created by non-specialists for 'educational purposes'), riddled with/nonsensical issues as one might expect but looks possibly professional. Then I asked another AI to spot issues. Obviously, I think this is dumb...!
Christie Thomas at University of Iowa presenting on the non-– AC GME research fellowship in nephrogenic that he started!
internalmedicine.medicine.uiowa.edu/renal-geneti...
Also McMaster U w/Lanktree medicine.healthsci.mcmaster.ca/divisions/ne...
internalmedicine.medicine.uiowa.edu/renal-geneti...
Also McMaster U w/Lanktree medicine.healthsci.mcmaster.ca/divisions/ne...
September 28, 2025 at 7:47 PM
Christie Thomas at University of Iowa presenting on the non-– AC GME research fellowship in nephrogenic that he started!
internalmedicine.medicine.uiowa.edu/renal-geneti...
Also McMaster U w/Lanktree medicine.healthsci.mcmaster.ca/divisions/ne...
internalmedicine.medicine.uiowa.edu/renal-geneti...
Also McMaster U w/Lanktree medicine.healthsci.mcmaster.ca/divisions/ne...
Great work led by Matt Lanktree on his nephrology genetics could fit into nephrology education and components of a nephrogenetics fellowship (exists at very few places)
www.seminarsinnephrology.org/article/S027...
www.seminarsinnephrology.org/article/S027...
September 27, 2025 at 10:18 PM
Great work led by Matt Lanktree on his nephrology genetics could fit into nephrology education and components of a nephrogenetics fellowship (exists at very few places)
www.seminarsinnephrology.org/article/S027...
www.seminarsinnephrology.org/article/S027...
Happy gloaming!
September 12, 2025 at 10:48 PM
Happy gloaming!
Some of the slides on the pro AI in HTN debate from Dr. Sau: lots of potential to use EKG, to predict incident hypertension, personalized treatment, identify those most likely to respond and benefit, improve clinical trial enrollment efficiently
September 10, 2025 at 12:26 PM
Some of the slides on the pro AI in HTN debate from Dr. Sau: lots of potential to use EKG, to predict incident hypertension, personalized treatment, identify those most likely to respond and benefit, improve clinical trial enrollment efficiently
AI on the brain as did introductions for the AHA AI in HTN debate!
September 10, 2025 at 1:19 AM
AI on the brain as did introductions for the AHA AI in HTN debate!
Very interesting work by Vivikta Rao on APOL1 Risk Variants in Preeclampsia. Humanized APOL1 mice developed gestation elevation in BP, proteinuria. Reversed by inaxaplin (Vx-147) #hypertension25
September 4, 2025 at 6:14 PM
Very interesting work by Vivikta Rao on APOL1 Risk Variants in Preeclampsia. Humanized APOL1 mice developed gestation elevation in BP, proteinuria. Reversed by inaxaplin (Vx-147) #hypertension25
I try not to do much self-help type books but this one was laying around an office I was in after several colleagues moved out of the office and was immensely helpful during a challenging time (K to R transition). Highly recommended!
August 20, 2025 at 5:14 PM
I try not to do much self-help type books but this one was laying around an office I was in after several colleagues moved out of the office and was immensely helpful during a challenging time (K to R transition). Highly recommended!
Creative finch nest
August 4, 2025 at 1:05 AM
Creative finch nest
Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...
July 28, 2025 at 7:30 PM
Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...
Proud that we have officially received certification as an AHA Comprehensive Hypertension Center!
July 17, 2025 at 9:00 PM
Proud that we have officially received certification as an AHA Comprehensive Hypertension Center!
Happy to share our paper on Genomic biobanks generating Insights into Genetic Kidney Disease" (shareable link next 50 days)
Biobanks + clinical data -> drug discovery,
Informing risk in complex dz, clarify what we know of monogenic dz, resolving VUS
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Biobanks + clinical data -> drug discovery,
Informing risk in complex dz, clarify what we know of monogenic dz, resolving VUS
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
July 15, 2025 at 2:11 AM
Happy to share our paper on Genomic biobanks generating Insights into Genetic Kidney Disease" (shareable link next 50 days)
Biobanks + clinical data -> drug discovery,
Informing risk in complex dz, clarify what we know of monogenic dz, resolving VUS
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Biobanks + clinical data -> drug discovery,
Informing risk in complex dz, clarify what we know of monogenic dz, resolving VUS
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Medication nonadherence is common in HTN and can be detected electronically. In this RCT, combined team-based primary care w/automated identification of pts with antihypertensive medication nonadherence did not lead to improvements in adherence or blood pressure.
cdn.jamanetwork.com/ama/content_...
cdn.jamanetwork.com/ama/content_...
July 14, 2025 at 12:31 PM
Medication nonadherence is common in HTN and can be detected electronically. In this RCT, combined team-based primary care w/automated identification of pts with antihypertensive medication nonadherence did not lead to improvements in adherence or blood pressure.
cdn.jamanetwork.com/ama/content_...
cdn.jamanetwork.com/ama/content_...
New Nordic Renal Diet - missed this nice small RCT of weekly home deliveries of this 'plant-forward' whole food approach. Reduced phos excretion, proteinuria by 39%, weight, abdominal fat.
pubmed.ncbi.nlm.nih.gov/37598748/
Also improved health-related quality of life
www.mdpi.com/2072-6643/16...
pubmed.ncbi.nlm.nih.gov/37598748/
Also improved health-related quality of life
www.mdpi.com/2072-6643/16...
June 24, 2025 at 12:50 PM
New Nordic Renal Diet - missed this nice small RCT of weekly home deliveries of this 'plant-forward' whole food approach. Reduced phos excretion, proteinuria by 39%, weight, abdominal fat.
pubmed.ncbi.nlm.nih.gov/37598748/
Also improved health-related quality of life
www.mdpi.com/2072-6643/16...
pubmed.ncbi.nlm.nih.gov/37598748/
Also improved health-related quality of life
www.mdpi.com/2072-6643/16...
Overall among the population, intervention increased proteinuria dx but not CKD or GDMT. Among those detected to have albuminuria by home test, 41% w/albuminuria, and those with albuminuria had higher new ACEi/ARB rx and possibly SGLT2i. Encouraging results but more to come to improve GDMT! #ada2025
June 21, 2025 at 12:14 AM
Overall among the population, intervention increased proteinuria dx but not CKD or GDMT. Among those detected to have albuminuria by home test, 41% w/albuminuria, and those with albuminuria had higher new ACEi/ARB rx and possibly SGLT2i. Encouraging results but more to come to improve GDMT! #ada2025