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alex0arbitino.bsky.social
@alex0arbitino.bsky.social
180 followers 2.3K following 0 posts
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Reposted
benhayden.bsky.social
Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do.

www.nature.com/articles/s41...
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
www.nature.com
December 4, 2025 at 5:56 PM
Reposted
fedeteloni.bsky.social
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
Reposted
idpseminars.bsky.social
We're back for our final seminar of 2025 with talks from @alexholehouse.bsky.social and Birthe Kragelund! 1 pm EST or 7 pm European time. If you're not already signed up, head on over to idpseminars.com to register!
Talk titles for IDPSeminars on Dec 4th at noon central time. Alex Holehouse (Washington University in St. Louis): Sequence-to-ensemble with STARLING Birthe Kragelund (University of Copenhagen): Disordered protein complexes and the origins of life
December 1, 2025 at 4:01 PM
Reposted
baym.lol
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Reposted
joachimgoedhart.bsky.social
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
Fig. 1: Rapid degradation of postsynaptic scaffold proteins fused to mTurquoise2 and a mAID degron.
November 22, 2025 at 7:59 PM
Reposted
wsctt.bsky.social
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:03 AM
Reposted
andersshansen.bsky.social
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
November 15, 2025 at 5:24 PM
Reposted
kieranrcampbell.bsky.social
Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.

Paper: www.nature.com/articles/s41...

Thanks to @sinaihealth.bsky.social
Screenshot of paper title
October 23, 2025 at 1:40 PM
Reposted
drericabiophd.bsky.social
Join us at #BARC2025 @sfbayrna.bsky.social BARC.ucsf.edu
Register by 11/14!

Trainee presentation awards will be handed out and generously supported by @rnasociety.bsky.social
November 5, 2025 at 7:23 PM
Reposted
michellefrei17.bsky.social
🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩‍🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️
D-CHAB @ethz.ch
www.nature.com/articles/s41...
Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
www.nature.com
November 5, 2025 at 9:29 PM
Reposted
superscijew.bsky.social
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
Reposted
natbiotech.nature.com
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Reposted
tonygamble.bsky.social
New Charlesworth & Charlesworth just dropped!!!
🧪🧬

HJ Muller and the relationship between sex chromosome degeneration and the evolution of dosage compensation url: academic.oup.com/gbe/article/...
HJ Muller and the relationship between sex chromosome degeneration and the evolution of dosage compensation
Abstract. A lack of recombination in the heterogametic sex between parts or all of newly evolving sex chromosomes results in the gradual accumulation of de
academic.oup.com
October 27, 2025 at 2:10 PM
Reposted
clairedeo.bsky.social
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Reposted
perrimonlab.bsky.social
New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon
bioRxiv 2025.10.10.681672; doi: doi.org/10.1101/2025...
A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Protein kinases orchestrate cellular processes through phosphorylation, yet the structural basis for their specific binding partner interactions remains largely unmapped. Here, we present a structure-...
doi.org
October 12, 2025 at 8:51 PM
Reposted
crick.ac.uk
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
Reposted
idajentoft.bsky.social
Excited to share our review on protein storage! Oocytes across species face the same challenge: maternal factors must be deposited and stored. Protein storage and proteostasis are exciting topics in germ cell biology, and I think we can learn a lot from other dormant systems! doi.org/10.1146/annu...
Protein Storage in Oocytes: Implications for Oocyte Quality, Embryonic Development, and Female Fertility
Maternal storage is a fundamental feature of female gametes and is essential for maintaining oocyte quality and preserving developmental competence. Embryonic development relies on maternally deposite...
doi.org
October 8, 2025 at 5:05 PM
Reposted
ysptsps.bsky.social
www.sciencedirect.com/science/arti...
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor…
www.sciencedirect.com
October 6, 2025 at 8:18 PM
Reposted
genetics-gsa.bsky.social
🚨 Two upcoming GSA panels highlight international research opportunities for early career scientists!

📅 Oct 20, 11 a.m. EDT
Grants and Funding in Europe
Learn how to secure funding abroad with insights from the @erc.europa.eu + The Research Bid.

@limor-zwi-dantsis.bsky.social

1/2🧵
October 6, 2025 at 4:06 PM
Reposted
natureportfolio.nature.com
This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 1:55 PM
Reposted
idpgrc.bsky.social
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
grc.org
October 2, 2025 at 3:21 PM
Reposted
camille-moore.bsky.social
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Reposted
proflhunter.bsky.social
ERC funding for researchers wanting to move to Europe from the US has increased, now relocation grants available of up to €4.5 million over 5 years. Applications up 5x.
www.politico.eu/article/euro...
Top US researchers rush to relocate to Europe
U.S.-based applicants to a prestigious EU research scheme have increased five-fold.
www.politico.eu
September 30, 2025 at 9:28 PM
Reposted
schurlab.bsky.social
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin

doi.org/10.1126/scia...
September 25, 2025 at 3:01 PM
Reposted
gerryhammond.bsky.social
Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids

Read the OA paper in JCB
September 10, 2025 at 7:56 PM