Armin Kousha 🇳🇴✈️🇺🇸
@akousha.bsky.social
Associate Researcher
Nizet laboratory
Departementet of Pediatrics
University of California-San Diego
https://profiles.ucsd.edu/armin.kousha
IAU>UOP>UiTØ>NMBU>UCSD
https://www.linkedin.com/in/armin-kousha-7243b916
Nizet laboratory
Departementet of Pediatrics
University of California-San Diego
https://profiles.ucsd.edu/armin.kousha
IAU>UOP>UiTØ>NMBU>UCSD
https://www.linkedin.com/in/armin-kousha-7243b916
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Pleased to share the new article from UCSD Skaggs School of Pharmacy PharmD/PhD student Daniel Sun focused on repurposing FDA-approved agents to inhibit virulence, restore antibiotic susceptibility, bolster host defenses, and modulate inflammation v. S. aureus
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
September 26, 2025 at 6:21 PM
Pleased to share the new article from UCSD Skaggs School of Pharmacy PharmD/PhD student Daniel Sun focused on repurposing FDA-approved agents to inhibit virulence, restore antibiotic susceptibility, bolster host defenses, and modulate inflammation v. S. aureus
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
In our continuing conversation with @nizet.bsky.social, MD, he discusses how his lab is studying how to repurpose antibiotics that susceptibility testing had shown to not be efficacious against certain infections. @ucsdpharmacy.bsky.social @ucsdmedschool.bsky.social #IDsky
What’s Old is New: Rediscovering Antibiotic Utility
In our continuing conversation with Victor Nizet, MD, he discusses how his lab is studying how to repurpose antibiotics that susceptibility testing had shown to not be efficacious against certain infe...
www.contagionlive.com
September 23, 2025 at 8:33 PM
In our continuing conversation with @nizet.bsky.social, MD, he discusses how his lab is studying how to repurpose antibiotics that susceptibility testing had shown to not be efficacious against certain infections. @ucsdpharmacy.bsky.social @ucsdmedschool.bsky.social #IDsky
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)
"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"
🔗 doi.org/10.1172/jci....
"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"
🔗 doi.org/10.1172/jci....
September 11, 2025 at 2:37 AM
Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)
"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"
🔗 doi.org/10.1172/jci....
"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"
🔗 doi.org/10.1172/jci....
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Our website had a small update. BlueSky feed is now integrated. If you want to know how to do this, you can reach out to website guru Doran Pauka (under contact on our site) veeninglab.com
Veening Lab
veeninglab.com
August 19, 2025 at 6:03 PM
Our website had a small update. BlueSky feed is now integrated. If you want to know how to do this, you can reach out to website guru Doran Pauka (under contact on our site) veeninglab.com
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
My divisions is hiring faculty! Let me know if you are interested in applying or have questions.
Faculty Search Alert!
The Division of Microbiology & Immunology at @UUtah is growing! We're hiring at all ranks in the tenure track—join a cutting-edge, collaborative research community in stunning Salt Lake City.
utah.peopleadmin.com/postings/186...
#AcademicJobs #Immunology #ScienceCareers
The Division of Microbiology & Immunology at @UUtah is growing! We're hiring at all ranks in the tenure track—join a cutting-edge, collaborative research community in stunning Salt Lake City.
utah.peopleadmin.com/postings/186...
#AcademicJobs #Immunology #ScienceCareers
August 11, 2025 at 7:15 PM
My divisions is hiring faculty! Let me know if you are interested in applying or have questions.
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Please share my 1 min video on the importance of maintaining NIH funding of infectious diseases and drug discovery research vs rising antibiotic resistance
Drastic budget cuts harm our health and imperil the next generation of scientists
More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3
Drastic budget cuts harm our health and imperil the next generation of scientists
More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3
August 7, 2025 at 8:40 PM
Please share my 1 min video on the importance of maintaining NIH funding of infectious diseases and drug discovery research vs rising antibiotic resistance
Drastic budget cuts harm our health and imperil the next generation of scientists
More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3
Drastic budget cuts harm our health and imperil the next generation of scientists
More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
July 18, 2025 at 3:15 AM
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Congratulations to @lozanzi.bsky.social and team on this cool story @cp-immunity.bsky.social: "Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections." Honored to have made a small contribution to such important work.
Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidized phospholipids accumulate upon microbial encounter, epigenetically suppress IL-10, and exacerbate harmful inflammation. Thus, targeting oxPLs represents a therapeutic strategy to treat deranged inflammation after infection.
dlvr.it
July 18, 2025 at 2:03 AM
Congratulations to @lozanzi.bsky.social and team on this cool story @cp-immunity.bsky.social: "Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections." Honored to have made a small contribution to such important work.
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
ⓅⒶⓇⒶⒹⒾⒼⓂ ⓈⒽⒾⒻⓉ
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
www.cell.com
July 18, 2025 at 12:34 AM
ⓅⒶⓇⒶⒹⒾⒼⓂ ⓈⒽⒾⒻⓉ
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Why do some infections kill despite low pathogen burden?
Zanoni Lab (Harvard/Boston Children's) identifies a novel host-driven mechanism
Bacterial Infection → oxPLs → AKT inhibition →
EZH2-mediated IL-10 silencing → hyperinflammation
Blocking oxPLs restores IL-10 → saves the mice!
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidized phospholipids accumulate upon microbial encounter, epigenetically suppress IL-10, and exacerbate harmful inflammation. Thus, targeting oxPLs represents a therapeutic strategy to treat deranged inflammation after infection.
dlvr.it
July 17, 2025 at 2:48 PM
Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Now published, congrats Bevika, Kinki, Vincent, Florian and Paddy! #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 14, 2025 at 9:16 PM
Now published, congrats Bevika, Kinki, Vincent, Florian and Paddy! #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Congratulations to Distinguished Professor Victor Nizet (@nizet.bsky.social) on receiving the Society for Pediatric Research's Maureen Andrew Mentor Award! The award recognizes exceptional mentorship that fosters excitement, creativity and scholarship, leading to outstanding research and teaching.
May 16, 2025 at 5:14 PM
Congratulations to Distinguished Professor Victor Nizet (@nizet.bsky.social) on receiving the Society for Pediatric Research's Maureen Andrew Mentor Award! The award recognizes exceptional mentorship that fosters excitement, creativity and scholarship, leading to outstanding research and teaching.
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
April 23, 2025 at 1:37 PM
Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫
🧵 1/6
www.jci.org/articles/vie...
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Congratulations to Dr. Victor Nizet @nizet.bsky.social, this year's recipients of the 2025 Maureen Andrew Mentor Award.
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
February 26, 2025 at 7:22 PM
Congratulations to Dr. Victor Nizet @nizet.bsky.social, this year's recipients of the 2025 Maureen Andrew Mentor Award.
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Humbled to receive this honor in the legacy of Dr. Maureen Andrew
The greatest privilege I have is to serve as a mentor—generating excitement and creativity among the next generation of child health researchers
This award truly recognizes their accomplishments—those of my trainees past and present
The greatest privilege I have is to serve as a mentor—generating excitement and creativity among the next generation of child health researchers
This award truly recognizes their accomplishments—those of my trainees past and present
Congratulations to Dr. Victor Nizet @nizet.bsky.social, this year's recipients of the 2025 Maureen Andrew Mentor Award.
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
Dr. Nizet will be speaking at PAS 2025 during the Eat. Greet. Celebrate: SPR Awards & New Members Reception.
Read more: ow.ly/mI4B50V5GHa
February 26, 2025 at 8:16 PM
Humbled to receive this honor in the legacy of Dr. Maureen Andrew
The greatest privilege I have is to serve as a mentor—generating excitement and creativity among the next generation of child health researchers
This award truly recognizes their accomplishments—those of my trainees past and present
The greatest privilege I have is to serve as a mentor—generating excitement and creativity among the next generation of child health researchers
This award truly recognizes their accomplishments—those of my trainees past and present
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
POSTDOC OPPORTUNITY IN LA JOLLA 🏝️
My colleague Marygorret Obonyo here at UC San Diego is hiring for a new postdoc position to study the link between Helicobacter pylori infection and gastric cancer — including a novel mouse model and links to interferon pathways (contact below)
PLEASE SHARE
My colleague Marygorret Obonyo here at UC San Diego is hiring for a new postdoc position to study the link between Helicobacter pylori infection and gastric cancer — including a novel mouse model and links to interferon pathways (contact below)
PLEASE SHARE
February 20, 2025 at 2:32 PM
POSTDOC OPPORTUNITY IN LA JOLLA 🏝️
My colleague Marygorret Obonyo here at UC San Diego is hiring for a new postdoc position to study the link between Helicobacter pylori infection and gastric cancer — including a novel mouse model and links to interferon pathways (contact below)
PLEASE SHARE
My colleague Marygorret Obonyo here at UC San Diego is hiring for a new postdoc position to study the link between Helicobacter pylori infection and gastric cancer — including a novel mouse model and links to interferon pathways (contact below)
PLEASE SHARE
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
“PREVENT: Preparedness through Respiratory Virus Epidemiology and Community Engagement” showcases UCSD’s expertise in large-scale COVID-19 clinical testing, viral genomic epidemiology, dissemination and implementation science, data and biospecimen management, and community partnership.
CDC Funds UC San Diego Pandemic Preparedness Study
Researchers at UC San Diego School of Medicine are serving as the central data hub for the CHARM Network, a new five-year pandemic preparedness initiative funded by the CDC. This includes ensuring rea...
today.ucsd.edu
January 12, 2025 at 10:48 AM
“PREVENT: Preparedness through Respiratory Virus Epidemiology and Community Engagement” showcases UCSD’s expertise in large-scale COVID-19 clinical testing, viral genomic epidemiology, dissemination and implementation science, data and biospecimen management, and community partnership.
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation: https://www.jci.org/articles/view/187055
Victor J. Torres comments on Chih-Ming Tsai et al. (https://www.jci.org/articles/view/179563)
Victor J. Torres comments on Chih-Ming Tsai et al. (https://www.jci.org/articles/view/179563)
December 27, 2024 at 4:33 PM
Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation: https://www.jci.org/articles/view/187055
Victor J. Torres comments on Chih-Ming Tsai et al. (https://www.jci.org/articles/view/179563)
Victor J. Torres comments on Chih-Ming Tsai et al. (https://www.jci.org/articles/view/179563)
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Saying goodbye to The Gonzo Lab 11 yr old instrument & saying hello to the new Star of Mass Spec, the Astral @thermofishersci.bsky.social
December 23, 2024 at 6:51 PM
Saying goodbye to The Gonzo Lab 11 yr old instrument & saying hello to the new Star of Mass Spec, the Astral @thermofishersci.bsky.social
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
We're live! The iSPY Explore Network is on a mission to uncover immune correlates of streptococcal infection. Join us on this exciting journey of discovery! #StrepResearch #iSPYExplore #UCSanDiego
December 18, 2024 at 4:36 AM
We're live! The iSPY Explore Network is on a mission to uncover immune correlates of streptococcal infection. Join us on this exciting journey of discovery! #StrepResearch #iSPYExplore #UCSanDiego
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Honored to have collaborated with Chih-Ming Tsai and George Liu on this study, “Pathobiont-driven antibody sialylation through IL-10 undermines vaccination”, now published in @jclinical-invest.bsky.social. A key step forward in understanding S. aureus vaccine failures
www.jci.org/articles/vie...
www.jci.org/articles/vie...
December 17, 2024 at 3:01 AM
Honored to have collaborated with Chih-Ming Tsai and George Liu on this study, “Pathobiont-driven antibody sialylation through IL-10 undermines vaccination”, now published in @jclinical-invest.bsky.social. A key step forward in understanding S. aureus vaccine failures
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
In the B cells, IL-10 directs enzymes to add sialic acid to the antibody Fc region, inhibiting their anti-SA activity, and reducing opsonophagocytic killing of the pathogen
Nostalgic for this professor (me) whose been around so long that both first (CMT) and senior (GL) authors are former postdocs
Nostalgic for this professor (me) whose been around so long that both first (CMT) and senior (GL) authors are former postdocs
December 16, 2024 at 5:47 PM
In the B cells, IL-10 directs enzymes to add sialic acid to the antibody Fc region, inhibiting their anti-SA activity, and reducing opsonophagocytic killing of the pathogen
Nostalgic for this professor (me) whose been around so long that both first (CMT) and senior (GL) authors are former postdocs
Nostalgic for this professor (me) whose been around so long that both first (CMT) and senior (GL) authors are former postdocs
Reposted by Armin Kousha 🇳🇴✈️🇺🇸
Led by Chih-Ming Tsai + Irshad Hasham, a fascinating new JCI paper from the George Liu Lab at UCSD Pediatrics shows that in mice who have previous Staphylococcus aureus (SA) exposure, B cells secrete abundant IL-10 when challenged with the SA antigens for a second time (in a vaccine)
Thread🧵 1 of 2
Thread🧵 1 of 2
Staph Vaccines Keep Failing and Scientists Finally Know Why
Researchers at UC San Diego have identified a key mechanism by which Staphylococcus aureus evades the immune response, leading to the failure of numerous vaccine trials. The bacteria triggers an overp...
scitechdaily.com
December 16, 2024 at 5:47 PM
Led by Chih-Ming Tsai + Irshad Hasham, a fascinating new JCI paper from the George Liu Lab at UCSD Pediatrics shows that in mice who have previous Staphylococcus aureus (SA) exposure, B cells secrete abundant IL-10 when challenged with the SA antigens for a second time (in a vaccine)
Thread🧵 1 of 2
Thread🧵 1 of 2