Are you a PhD interested in #adultneurogenesis and #spatialtranscriptomic in the mouse brain ?
You can apply now for a #JuanDeLaCierva posdoctoral grant from MICIU at our lab @institutocajal.bsky.social @csic.es 🧠🐭
Please, write us before the 5th of December !!
⬇️
aei.gob.es/convocatorias/…

!! Qué gran equipo de neurocientific@s corredores tenemos en el @institutocajal.bsky.social @csic.es !!!
!Celebrando la Neurociencia! 🧠🎉🏃🏼
#YoCorroPorLaCiencia
@guiomarniso.bsky.social

Preparada para celebrar la Ciencia con la tradicional Carrera de la Ciencia del @csic.es . #YoCorroPorLaCiencia
#CorrePorTusNeuronas @institutocajal.bsky.social

El próximo sábado 27 de septiembre estaremos hablando de la #enfermedadRara #SyndromeLambShaffer con las familias de los pacientes. Encuentro abierto a científicos, médicos y familiares de pacientes.
Nos vemos allí!
@institutocajal.bsky.social @csic.es @rarascsic.bsky.social 🧬🧠

We are very honored to receive Professor Tzumin Lee from Míchigan University
next Tuesday 23rd Septiembre at @institutocajal.bsky.social @csic.es
Looking forward for his Talk !!!

Excellent Symposium this morning on Cell fate in human #neurodevelopment and disease at #SENC2025 organized by @sarabiz86.bsky.social & Ana Uzkiano.🧠

7️⃣To sum up, our work shows that Sox5 is crucial to balance shallow and deep #Quiescence in NSCs during the first postnatal weeks of #DentateGyrus development. This balance ⚖️ is crucial for long-lasting #AdultNeurogenesis✨🔬

6️⃣And not just in🧫!! We confirmed BMP upregulation in P14 🐁!! Strikingly, when we used a specific BMP inhibitor around P14 🐁, we partially rescued the over-activated neurogenesis seen in P30 Sox5 mutants. This stresses the role of BMP signalling in the acquisition of the right quiescence deepness!

5️⃣To confirm this, we studied NSCs in vitro 🧫. Here, we found that Sox5 prevents excessive activation of the BMP canonical signalling pathway, which we have now determined is associated with the shallow quiescent state in this model.

4️⃣To dive deeper🤿in the changes that occur during the critical window of P14 at the #Hippocampus, we performed transcriptomic analysis of Sox5 mutant NSCs. This analysis revealed dramatic changes in developmental programs, including an upregulation ⬆️ of the BMP signalling.

3️⃣When Sox5 is lost, there is an accumulation of shallow quiescent NSCs at P14 more prone to activation. This causes a neurogenic burst in the adult #DentateGyrus at P30 and ultimately results in a premature depletion of the NSC pool. Essentially, too much too soon leads to not enough later !!

2️⃣How did we figure this out? We used conditional mutant 🐁 during critical developmental stages & found that Sox5 is required to restrict the initial entry in #Quiescence of NSCs. Intriguingly, we discovered a critical window in the second postnatal week when NSCs build up a shallow quiescent state.

Ever wondered how adult #NeuralStemCells develop and acquire their lifelong potential?
Excited to share our latest work on the origin of #AdultNeurogenesis by Cris Medina
@paulatiradom.bsky.social Lingling Li & @pilar-rguezm.bsky.social now in @plosbiology.org🧪🧠
@institutocajal.bsky.social
👇🧵

If you are a fan of #neurogenesis, #evodevo and #transcriptomics, you shouldn´t miss next Friday seminar by Fernando García-Moreno from @achucarro.bsky.social .
See you at @institutocajal.bsky.social @csic.es
🧠🔬🧬🐁🐣🦎

Don't miss next seminar at @institutocajal.bsky.social
by @BaleriolaLab
if you are a fan of #localtranslation, #astrocytes, #extracellular_vesicles and #neurons. See you next Friday!
🧠🔬🧫🧬🐁
@elcsic.bsky.social