Acta Neuropsychiatrica
@actaneuropsych.bsky.social
An International Journal of Translational Neuropsychiatry
https://www.cambridge.org/core/journals/acta-neuropsychiatrica/information/about-this-journal
https://www.cambridge.org/core/journals/acta-neuropsychiatrica/information/about-this-journal
✨ At the center of this discussion is the dorsal diencephalic conduction system (DDCS)
• a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus)
• central to flexible responses in social, defensive, and reward-related contexts
• and a decisive hot spot in neuropsychiatry.
• a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus)
• central to flexible responses in social, defensive, and reward-related contexts
• and a decisive hot spot in neuropsychiatry.
December 5, 2025 at 7:12 PM
✨ At the center of this discussion is the dorsal diencephalic conduction system (DDCS)
• a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus)
• central to flexible responses in social, defensive, and reward-related contexts
• and a decisive hot spot in neuropsychiatry.
• a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus)
• central to flexible responses in social, defensive, and reward-related contexts
• and a decisive hot spot in neuropsychiatry.
🧭 Modern humans often face intense stress when uprooted from a familiar and safe environment… yet our nomadic ancestors evolved under constant movement as hunter-gatherers.
December 5, 2025 at 7:12 PM
🧭 Modern humans often face intense stress when uprooted from a familiar and safe environment… yet our nomadic ancestors evolved under constant movement as hunter-gatherers.
Could the neural plasticity associated with psychedelics extend beyond mood or perception towards functional recovery itself?
✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.
✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.
November 21, 2025 at 2:49 PM
Could the neural plasticity associated with psychedelics extend beyond mood or perception towards functional recovery itself?
✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.
✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.
🧠 Could psychedelics help rewire the brain–body disconnect?
💊 + 🧍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.
💊 + 🧍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.
November 21, 2025 at 2:49 PM
🧠 Could psychedelics help rewire the brain–body disconnect?
💊 + 🧍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.
💊 + 🧍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.
💡 The hybrid format (digital + classroom) and easy-to-read, gamified materials made the program accessible, engaging, and equally effective across rural and urban schools, as well as regular and special education centers.
#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth
#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth
November 7, 2025 at 6:18 PM
💡 The hybrid format (digital + classroom) and easy-to-read, gamified materials made the program accessible, engaging, and equally effective across rural and urban schools, as well as regular and special education centers.
#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth
#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth
🩺 Building Early Pain Literacy
Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better
✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.
Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better
✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.
November 7, 2025 at 6:18 PM
🩺 Building Early Pain Literacy
Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better
✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.
Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better
✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.
🌿 Results:
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.
October 27, 2025 at 2:07 PM
🌿 Results:
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.
🍄 What does the evidence say on Psilocybin Therapy in Depression?
📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials.
Populations included treatment-resistant depression and varied dosing and adjunctive protocols
📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials.
Populations included treatment-resistant depression and varied dosing and adjunctive protocols
October 27, 2025 at 2:07 PM
🍄 What does the evidence say on Psilocybin Therapy in Depression?
📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials.
Populations included treatment-resistant depression and varied dosing and adjunctive protocols
📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials.
Populations included treatment-resistant depression and varied dosing and adjunctive protocols
⚡Proinflammatory cytokines activate breakdown into tryptophan catabolites (TRYCATs). However, some TRYCATs (like kynurenine, 3HK) are neurotoxic!
Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid,
shifting the quinolinic:kynurenic ratio toward neurotoxicity.
Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid,
shifting the quinolinic:kynurenic ratio toward neurotoxicity.
October 24, 2025 at 2:42 PM
⚡Proinflammatory cytokines activate breakdown into tryptophan catabolites (TRYCATs). However, some TRYCATs (like kynurenine, 3HK) are neurotoxic!
Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid,
shifting the quinolinic:kynurenic ratio toward neurotoxicity.
Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid,
shifting the quinolinic:kynurenic ratio toward neurotoxicity.
🧩 Rethinking Schizophrenia
Emerging evidence suggests schizophrenia has 2 biologically distinct forms:
🔹 Major Neurocognitive Psychosis (MNP)
🔹 Simple Neurocognitive Psychosis (SNP)
Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)
Emerging evidence suggests schizophrenia has 2 biologically distinct forms:
🔹 Major Neurocognitive Psychosis (MNP)
🔹 Simple Neurocognitive Psychosis (SNP)
Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)
October 24, 2025 at 2:42 PM
🧩 Rethinking Schizophrenia
Emerging evidence suggests schizophrenia has 2 biologically distinct forms:
🔹 Major Neurocognitive Psychosis (MNP)
🔹 Simple Neurocognitive Psychosis (SNP)
Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)
Emerging evidence suggests schizophrenia has 2 biologically distinct forms:
🔹 Major Neurocognitive Psychosis (MNP)
🔹 Simple Neurocognitive Psychosis (SNP)
Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)
Navigating the Use of Xanomeline/Trospium (Cobenfy/KarXT)
KarXT marks a significant shift as the first muscarinic
Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action:
doi.org/10.1017/neu....
KarXT marks a significant shift as the first muscarinic
Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action:
doi.org/10.1017/neu....
October 17, 2025 at 11:01 AM
Navigating the Use of Xanomeline/Trospium (Cobenfy/KarXT)
KarXT marks a significant shift as the first muscarinic
Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action:
doi.org/10.1017/neu....
KarXT marks a significant shift as the first muscarinic
Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action:
doi.org/10.1017/neu....
Voice revealed:
🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger
🚻 These vocal patterns differed meaningfully between males and females
🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy
🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger
🚻 These vocal patterns differed meaningfully between males and females
🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy
October 10, 2025 at 12:10 PM
Voice revealed:
🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger
🚻 These vocal patterns differed meaningfully between males and females
🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy
🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger
🚻 These vocal patterns differed meaningfully between males and females
🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy
🎤 Voice over for measuring the physiological stress response.
What if the speech could be used as a digital biomarker of stress?
Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.
What if the speech could be used as a digital biomarker of stress?
Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.
October 10, 2025 at 12:10 PM
🎤 Voice over for measuring the physiological stress response.
What if the speech could be used as a digital biomarker of stress?
Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.
What if the speech could be used as a digital biomarker of stress?
Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.
Policy makers & clinical leaders: 💡 How are we investing in comprehensive, inter-professional training for clozapine management in our systems?
September 25, 2025 at 1:30 PM
Policy makers & clinical leaders: 💡 How are we investing in comprehensive, inter-professional training for clozapine management in our systems?
Is Clozapine use hindered?🚧A recent paper sheds light on how to transform care for treatment-resistant schizophrenia
Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines
Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines
September 25, 2025 at 1:30 PM
Is Clozapine use hindered?🚧A recent paper sheds light on how to transform care for treatment-resistant schizophrenia
Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines
Clozapine initiation and maintenance are hampered by misconceptions about side effects and monitoring (e.g., hospitalization/frequent tests) 🩺📋, despite confidence in the guidelines
🧬 Transcription (AP-1 Complex)
🧱 Cellular Structure (Cytoskeleton)
📦 Intracellular trafficking of receptors & Endocytosis
🧪 Epigenetics (Histone Binding)
🧱 Cellular Structure (Cytoskeleton)
📦 Intracellular trafficking of receptors & Endocytosis
🧪 Epigenetics (Histone Binding)
September 19, 2025 at 7:42 PM
🧬 Transcription (AP-1 Complex)
🧱 Cellular Structure (Cytoskeleton)
📦 Intracellular trafficking of receptors & Endocytosis
🧪 Epigenetics (Histone Binding)
🧱 Cellular Structure (Cytoskeleton)
📦 Intracellular trafficking of receptors & Endocytosis
🧪 Epigenetics (Histone Binding)
🔬Molecular Mechanisms of Amisulpride
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
September 19, 2025 at 7:42 PM
🔬Molecular Mechanisms of Amisulpride
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology (SCNP) + the International College of Neuropsychopharmacology!
Join us for this unique event which promises to be an outstanding meeting of science & collaboration
@ijnp.bsky.social
Join us for this unique event which promises to be an outstanding meeting of science & collaboration
@ijnp.bsky.social
September 10, 2025 at 4:39 PM
📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology (SCNP) + the International College of Neuropsychopharmacology!
Join us for this unique event which promises to be an outstanding meeting of science & collaboration
@ijnp.bsky.social
Join us for this unique event which promises to be an outstanding meeting of science & collaboration
@ijnp.bsky.social
🐁Complementary preclinical work shows converging effects: these agents reduce heroin-seeking behavior and opioid self-administration in animal models.
🍽️🧠How could these findings support integrated use?
GLP-1 signaling intersects with reward pathways, satiety, and stress responses.
🍽️🧠How could these findings support integrated use?
GLP-1 signaling intersects with reward pathways, satiety, and stress responses.
September 5, 2025 at 1:22 PM
🐁Complementary preclinical work shows converging effects: these agents reduce heroin-seeking behavior and opioid self-administration in animal models.
🍽️🧠How could these findings support integrated use?
GLP-1 signaling intersects with reward pathways, satiety, and stress responses.
🍽️🧠How could these findings support integrated use?
GLP-1 signaling intersects with reward pathways, satiety, and stress responses.
💊GLP-1 Agonists & Opioid Abuse
New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD)
🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans
New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD)
🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans
September 5, 2025 at 1:22 PM
💊GLP-1 Agonists & Opioid Abuse
New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD)
🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans
New translational work examines whether GLP-1 receptor agonists(GLP-1 RAs) could support treatment and/or prevention in people living with opioid use disorder(OUD)
🛡️Early evidence suggests GLP-1 RA administration was linked to reduced risk of opioid overdose in humans
🔬 Preclinical studies (in vitro & in vivo) point to immunomodulatory effects via:
🔹 Serotonin receptors
🔹 Sigma-1 receptor
🔹 TrkB receptor
For clinicians and researchers, these findings highlight the importance of looking beyond the synapse.
🔹 Serotonin receptors
🔹 Sigma-1 receptor
🔹 TrkB receptor
For clinicians and researchers, these findings highlight the importance of looking beyond the synapse.
August 29, 2025 at 11:17 AM
🔬 Preclinical studies (in vitro & in vivo) point to immunomodulatory effects via:
🔹 Serotonin receptors
🔹 Sigma-1 receptor
🔹 TrkB receptor
For clinicians and researchers, these findings highlight the importance of looking beyond the synapse.
🔹 Serotonin receptors
🔹 Sigma-1 receptor
🔹 TrkB receptor
For clinicians and researchers, these findings highlight the importance of looking beyond the synapse.
🧠✨ Psychedelics & the Neuroimmune System
A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.
A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.
August 29, 2025 at 11:17 AM
🧠✨ Psychedelics & the Neuroimmune System
A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.
A new review in Acta Neuropsychiatrica explores how 5-HT2A receptor psychedelics interact with the immune system, and how this interplay may also drive neuronal changes.
📊FGF19 levels were significantly associated with BDI depression scores across all participants.
🚭In non-smokers, higher FGF19 correlated with greater depressive symptoms but...
❌This link was absent in smokers, despite them having higher CSF FGF19 levels and higher BDI scores than non-smokers.
🚭In non-smokers, higher FGF19 correlated with greater depressive symptoms but...
❌This link was absent in smokers, despite them having higher CSF FGF19 levels and higher BDI scores than non-smokers.
August 8, 2025 at 7:43 PM
📊FGF19 levels were significantly associated with BDI depression scores across all participants.
🚭In non-smokers, higher FGF19 correlated with greater depressive symptoms but...
❌This link was absent in smokers, despite them having higher CSF FGF19 levels and higher BDI scores than non-smokers.
🚭In non-smokers, higher FGF19 correlated with greater depressive symptoms but...
❌This link was absent in smokers, despite them having higher CSF FGF19 levels and higher BDI scores than non-smokers.
🧩FGF19: Linking Smoke and Mental Health 🚬
Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target
A recent study on FGF19 in depression and smoking revealed:
Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target
A recent study on FGF19 in depression and smoking revealed:
August 8, 2025 at 7:43 PM
🧩FGF19: Linking Smoke and Mental Health 🚬
Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target
A recent study on FGF19 in depression and smoking revealed:
Fibroblast growth factor 19 (FGF19) regulates a wide range of biological functions (energy homeostasis, proliferation, survival, and migration) and has an emerging role as an oncology target
A recent study on FGF19 in depression and smoking revealed:
🛤️ "The path is known by asking those who have walked it before." — Zulu proverb (South Africa)
🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.
🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.
August 1, 2025 at 4:20 PM
🛤️ "The path is known by asking those who have walked it before." — Zulu proverb (South Africa)
🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.
🧠 This new study in Acta Neuropsychiatrica examined modifiable & non-modifiable factors linked to mental health changes during COVID-19.