ACR Journals
@acr-journals.bsky.social
Official journals of the American College of Rheumatology:
Arthritis & Rheumatology
Arthritis Care & Research
ACR Open Rheumatology
SoMe Editor: Karen Costenbader, MD, MPH
Arthritis & Rheumatology
Arthritis Care & Research
ACR Open Rheumatology
SoMe Editor: Karen Costenbader, MD, MPH
Key findings:
•IL-33 elevated in IIM-ILD patient sera & lungs
•IL-33 deletion attenuated lung inflammation & fibrosis in myositis-assoc. ILD mice
•in vitro, IL-33 knockdown suppressed ERK-driven EMT
•ERK inhibition mitigated ILD progression
•IL-33 elevated in IIM-ILD patient sera & lungs
•IL-33 deletion attenuated lung inflammation & fibrosis in myositis-assoc. ILD mice
•in vitro, IL-33 knockdown suppressed ERK-driven EMT
•ERK inhibition mitigated ILD progression
November 28, 2025 at 1:47 PM
Key findings:
•IL-33 elevated in IIM-ILD patient sera & lungs
•IL-33 deletion attenuated lung inflammation & fibrosis in myositis-assoc. ILD mice
•in vitro, IL-33 knockdown suppressed ERK-driven EMT
•ERK inhibition mitigated ILD progression
•IL-33 elevated in IIM-ILD patient sera & lungs
•IL-33 deletion attenuated lung inflammation & fibrosis in myositis-assoc. ILD mice
•in vitro, IL-33 knockdown suppressed ERK-driven EMT
•ERK inhibition mitigated ILD progression
DASI questionnaire & timed up and go test had high negative predictive value (unlikely to have very low fitness), but low positive predictive value. Suggests better use as screening tools to rule out low fitness
Multiple regression equations to predict peak V̇O₂
Multiple regression equations to predict peak V̇O₂
November 26, 2025 at 1:57 PM
DASI questionnaire & timed up and go test had high negative predictive value (unlikely to have very low fitness), but low positive predictive value. Suggests better use as screening tools to rule out low fitness
Multiple regression equations to predict peak V̇O₂
Multiple regression equations to predict peak V̇O₂
Review in ACR Open Rheumatology summarizes concepts & recommendations for advancing cellular therapy for systemic autoimmune diseases
doi.org/10.1002/acr2...
#Medsky
doi.org/10.1002/acr2...
#Medsky
Cellular Therapy for Systemic Autoimmune Diseases: New Opportunities for Future Research and Interdisciplinary Collaboration
Systemic autoimmune diseases (sAIDs) affect 1 in 10 people and represent a leading cause of death in women under the age of 65 years. Despite the emergence of targeted-biologic therapies, mortality r...
doi.org
November 25, 2025 at 2:09 PM
Review in ACR Open Rheumatology summarizes concepts & recommendations for advancing cellular therapy for systemic autoimmune diseases
doi.org/10.1002/acr2...
#Medsky
doi.org/10.1002/acr2...
#Medsky
• weight-band dosing of 200 mg qw for ≥50 kg, every 10 days for 30 to <50 kg, and q2w for 15 to <30 kg
• results showed consistent exposure across the weight bands
• PD & efficacy consistent with previous studies
• by week 52, 82% (18/22) had ≥4-point reduction in SELENA-SLEDAI
• results showed consistent exposure across the weight bands
• PD & efficacy consistent with previous studies
• by week 52, 82% (18/22) had ≥4-point reduction in SELENA-SLEDAI
November 24, 2025 at 1:28 PM
• weight-band dosing of 200 mg qw for ≥50 kg, every 10 days for 30 to <50 kg, and q2w for 15 to <30 kg
• results showed consistent exposure across the weight bands
• PD & efficacy consistent with previous studies
• by week 52, 82% (18/22) had ≥4-point reduction in SELENA-SLEDAI
• results showed consistent exposure across the weight bands
• PD & efficacy consistent with previous studies
• by week 52, 82% (18/22) had ≥4-point reduction in SELENA-SLEDAI
"While low-dose CT scans of the chest provide high-value lung cancer screening in patients with RA, McDermott [et al] have shown in this study they may also help screen for the presence of RA-associated lung disease. LDCT for lung cancer screening just may enable us to kill two birds with 1 stone."
November 23, 2025 at 10:02 PM
"While low-dose CT scans of the chest provide high-value lung cancer screening in patients with RA, McDermott [et al] have shown in this study they may also help screen for the presence of RA-associated lung disease. LDCT for lung cancer screening just may enable us to kill two birds with 1 stone."
Review: Brain-focused research and neuroimaging in rheumatology practice
doi.org/10.1002/acr....
doi.org/10.1002/acr....
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis
Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral in....
doi.org
November 22, 2025 at 4:38 PM
Review: Brain-focused research and neuroimaging in rheumatology practice
doi.org/10.1002/acr....
doi.org/10.1002/acr....
Fractional excretion of urate modulates urate-lowering response to allopurinol
doi.org/10.1002/acr....
External validation of VARA-ILD-GRS & VARA-ILD combined risk score for identifying RA-ILD risk
doi.org/10.1002/acr....
doi.org/10.1002/acr....
External validation of VARA-ILD-GRS & VARA-ILD combined risk score for identifying RA-ILD risk
doi.org/10.1002/acr....
November 22, 2025 at 4:38 PM
Fractional excretion of urate modulates urate-lowering response to allopurinol
doi.org/10.1002/acr....
External validation of VARA-ILD-GRS & VARA-ILD combined risk score for identifying RA-ILD risk
doi.org/10.1002/acr....
doi.org/10.1002/acr....
External validation of VARA-ILD-GRS & VARA-ILD combined risk score for identifying RA-ILD risk
doi.org/10.1002/acr....
Genetic contributions of C4A & C4B in SSc subtypes susceptibility
doi.org/10.1002/art....
Dynamics of circulating anti-GPI antibodies in K/BxN mice
doi.org/10.1002/art....
doi.org/10.1002/art....
Dynamics of circulating anti-GPI antibodies in K/BxN mice
doi.org/10.1002/art....
November 22, 2025 at 1:33 PM
Genetic contributions of C4A & C4B in SSc subtypes susceptibility
doi.org/10.1002/art....
Dynamics of circulating anti-GPI antibodies in K/BxN mice
doi.org/10.1002/art....
doi.org/10.1002/art....
Dynamics of circulating anti-GPI antibodies in K/BxN mice
doi.org/10.1002/art....
Potential immunologic signature of Treg dysfunctionality in OA-related pain
doi.org/10.1002/art....
Linezolid inhibits mitochondrial translation & ameliorates fibrotic tissue remodeling
doi.org/10.1002/art....
doi.org/10.1002/art....
Linezolid inhibits mitochondrial translation & ameliorates fibrotic tissue remodeling
doi.org/10.1002/art....
November 22, 2025 at 1:33 PM
Potential immunologic signature of Treg dysfunctionality in OA-related pain
doi.org/10.1002/art....
Linezolid inhibits mitochondrial translation & ameliorates fibrotic tissue remodeling
doi.org/10.1002/art....
doi.org/10.1002/art....
Linezolid inhibits mitochondrial translation & ameliorates fibrotic tissue remodeling
doi.org/10.1002/art....