Aashli Pathni, PhD
@aashlipathni.bsky.social
Postdoc at the University of Maryland studying T cell immunology and biophysics 🔬| she/her | #WomenInScience 👩🔬
Reposted by Aashli Pathni, PhD
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
December 5, 2025 at 4:11 PM
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
Reposted by Aashli Pathni, PhD
THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️
May 16, 2025 at 4:00 PM
THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️
Reposted by Aashli Pathni, PhD
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Aashli Pathni, PhD
🥼A new tissue expansion method developed by researchers in the Wang & Tillberg labs & collaborators @uwmadison.bsky.social enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations ➡️ hhmi.news/4ixHOZZ
New technique expands tissues so hundreds of biomolecules can be seen inside cells
A new tissue expansion method developed by Janelia and University of Wisconsin-Madison researchers enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules
hhmi.news
April 22, 2025 at 2:45 PM
🥼A new tissue expansion method developed by researchers in the Wang & Tillberg labs & collaborators @uwmadison.bsky.social enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations ➡️ hhmi.news/4ixHOZZ
Reposted by Aashli Pathni, PhD
Sharing all my research via a tutorial website was the most unique idea I had during my PhD. I took advantage of my years of blogging experience via Wordpress, but it still took a lot of work. I'm glad it has connected me to scientists across the globe. Visit hydrogeldesign.org to learn more!
Hydrogel Design - Make better hydrogels.
A scientific communication platform for hydrogel design by Nate Richbourg
hydrogeldesign.org
April 17, 2025 at 6:12 PM
Sharing all my research via a tutorial website was the most unique idea I had during my PhD. I took advantage of my years of blogging experience via Wordpress, but it still took a lot of work. I'm glad it has connected me to scientists across the globe. Visit hydrogeldesign.org to learn more!
Reposted by Aashli Pathni, PhD
In 2016, the Kishony Lab at Harvard Medical School put together this demonstration of acquired antibiotic resistance in E. coli bacteria, creating a mega-Petri dish (2' x 4') with a stepped gradient of antibiotic.
Seeing the mutants emerge & spread is an elegant demo of evolutionary change.
Seeing the mutants emerge & spread is an elegant demo of evolutionary change.
The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab)
YouTube video by Harvard Medical School
youtu.be
April 13, 2025 at 2:01 PM
In 2016, the Kishony Lab at Harvard Medical School put together this demonstration of acquired antibiotic resistance in E. coli bacteria, creating a mega-Petri dish (2' x 4') with a stepped gradient of antibiotic.
Seeing the mutants emerge & spread is an elegant demo of evolutionary change.
Seeing the mutants emerge & spread is an elegant demo of evolutionary change.
Reposted by Aashli Pathni, PhD
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
April 9, 2025 at 3:03 PM
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Reposted by Aashli Pathni, PhD
A huge day for mapping in life science!
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...
April 9, 2025 at 9:34 PM
A huge day for mapping in life science!
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...
Reposted by Aashli Pathni, PhD
Picture this! What if the scientific community had a standardized system for storing and sharing image data?
In a new @naturemethods.bsky.social perspective, an international team calls for investment into long term and openly accessible resources: www.nature.com/articles/s41...
🧪 #cellbio
In a new @naturemethods.bsky.social perspective, an international team calls for investment into long term and openly accessible resources: www.nature.com/articles/s41...
🧪 #cellbio
Enabling global image data sharing in the life sciences - Nature Methods
This Perspective provides a roadmap toward globally federated open data resources for bioimaging data.
www.nature.com
April 2, 2025 at 7:26 PM
Picture this! What if the scientific community had a standardized system for storing and sharing image data?
In a new @naturemethods.bsky.social perspective, an international team calls for investment into long term and openly accessible resources: www.nature.com/articles/s41...
🧪 #cellbio
In a new @naturemethods.bsky.social perspective, an international team calls for investment into long term and openly accessible resources: www.nature.com/articles/s41...
🧪 #cellbio
Reposted by Aashli Pathni, PhD
#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb
IL-1β+ macrophages and the control of pathogenic inflammation in cancer
While highlighting the complexity and heterogeneity of tumor immune microenvironments,
the application of single-cell analyses in human cancers has identified recurrent
subsets of tumor-associated mac...
dlvr.it
April 1, 2025 at 1:22 AM
#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb
Reposted by Aashli Pathni, PhD
🧬 February's most-read Genetics paper looks at how #RNA travels between cells to control genes across generations #epigenetics: buff.ly/ulMGsBH
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
March 14, 2025 at 9:01 PM
🧬 February's most-read Genetics paper looks at how #RNA travels between cells to control genes across generations #epigenetics: buff.ly/ulMGsBH
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
Reposted by Aashli Pathni, PhD
I figured that the one month anniversary of my first ever publication is a good time to join bluesky! Many thanks to Nathan Shugarts Devanapally and Antony Jose for letting me work on this in the first half of my PhD career. More on this story soon (hopefully in the coming year)!
🧬 February's most-read Genetics paper looks at how #RNA travels between cells to control genes across generations #epigenetics: buff.ly/ulMGsBH
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp
March 17, 2025 at 12:52 AM
I figured that the one month anniversary of my first ever publication is a good time to join bluesky! Many thanks to Nathan Shugarts Devanapally and Antony Jose for letting me work on this in the first half of my PhD career. More on this story soon (hopefully in the coming year)!
Reposted by Aashli Pathni, PhD
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
March 9, 2025 at 4:00 PM
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
Reposted by Aashli Pathni, PhD
In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial
An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.
www.science.org
March 6, 2025 at 12:02 AM
In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
Reposted by Aashli Pathni, PhD
I wonder if spreading extremely encouraging experimental results on helping treat pancreatic cancer with *gasp* mRNA vaccines may help people who have villainized them come around. This is a good press release on the study and links to the Nature paper. www.mskcc.org/news/can-mrn...
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 28, 2025 at 5:02 PM
I wonder if spreading extremely encouraging experimental results on helping treat pancreatic cancer with *gasp* mRNA vaccines may help people who have villainized them come around. This is a good press release on the study and links to the Nature paper. www.mskcc.org/news/can-mrn...
Reposted by Aashli Pathni, PhD
The most achingly beautiful explanation of what science is, from @edyong209.bsky.social: “the idea that much of the world is hidden from us, that we don’t perceive it and don’t understand it, and that it is worth understanding and it is necessary to understand.”
www.nytimes.com/2025/02/22/m...
www.nytimes.com/2025/02/22/m...
‘The Interview’: Ed Yong Wants to Show You the Hidden Reality of the World
The Pulitzer Prize-winning science writer talks about burnout from covering the pandemic and how bird-watching gave him a new sense of hope.
www.nytimes.com
February 22, 2025 at 3:46 PM
The most achingly beautiful explanation of what science is, from @edyong209.bsky.social: “the idea that much of the world is hidden from us, that we don’t perceive it and don’t understand it, and that it is worth understanding and it is necessary to understand.”
www.nytimes.com/2025/02/22/m...
www.nytimes.com/2025/02/22/m...
Reposted by Aashli Pathni, PhD
February 19, 2025 at 3:03 PM
Reposted by Aashli Pathni, PhD
At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis!
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al
February 20, 2025 at 7:07 PM
At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis!
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al
Reposted by Aashli Pathni, PhD
Visualizing RNA in live cells using CRISPR
nature.com/articles/s41...
nature.com/articles/s41...
Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology
Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.
nature.com
February 18, 2025 at 2:34 PM
Visualizing RNA in live cells using CRISPR
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Aashli Pathni, PhD
Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://buff.ly/4jU4e9C
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
February 14, 2025 at 4:19 PM
Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://buff.ly/4jU4e9C
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
Reposted by Aashli Pathni, PhD
#medsky#pedsky#idsky#immunosky 🧪
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
A Single-Dose Breakthrough: PfSPZ-LARC Vaccines Offer Transformative Protection Against Malaria – Sanaria
sanaria.com
February 13, 2025 at 1:23 PM
#medsky#pedsky#idsky#immunosky 🧪
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
Reposted by Aashli Pathni, PhD
Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards…
What would you do with this?
Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵
What would you do with this?
Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵
February 8, 2025 at 7:49 AM
Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards…
What would you do with this?
Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵
What would you do with this?
Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵