Zeeba Manavi
zeebamehrin.bsky.social
Zeeba Manavi
@zeebamehrin.bsky.social
TL1 pre-doc fellow in Jeffrey Huang Lab @Georgetown studying senescence, neuroinflammation & repair in multiple sclerosis
Pinned
Happy to see my work published in Journal of Neuroinflammation! Thanks to my amazing mentor @jkhuang.bsky.social and all the co-authors George Melchor, Meghan Bullard, @philgrossphd.bsky.social for their continued help and support. jneuroinflammation.biomedcentral.com/articles/10....
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...
jneuroinflammation.biomedcentral.com
Reposted by Zeeba Manavi
Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies
www.science.org/doi/10.1126/...
September 10, 2025 at 11:02 PM
Happy to see my work published in Journal of Neuroinflammation! Thanks to my amazing mentor @jkhuang.bsky.social and all the co-authors George Melchor, Meghan Bullard, @philgrossphd.bsky.social for their continued help and support. jneuroinflammation.biomedcentral.com/articles/10....
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...
jneuroinflammation.biomedcentral.com
April 8, 2025 at 8:32 PM
Reposted by Zeeba Manavi
Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...
jneuroinflammation.biomedcentral.com
April 8, 2025 at 3:32 PM
Reposted by Zeeba Manavi
Please join the 170 MS Activists visiting Capitol Hill this week by sending Congress a message today urging support for funding medical research through the MS Research Program (MSRP) at the Congressionally Directed Medical Research Program (CDMRP) and the NIH. ACT NOW
nmss.quorum.us/campaign/PPC...
Act Now: Contact Congress About MS Research Funding
Send a message to your legislators about the important of MS Research
nmss.quorum.us
March 24, 2025 at 12:00 PM
Reposted by Zeeba Manavi
Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...

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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications
The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...
www.nature.com
March 7, 2025 at 1:57 PM
Reposted by Zeeba Manavi
I’m happy to share a free new resource to explore published single cell transcriptomic datasets from the Sanofi Rare and Neurologic Diseases Therapeutic Area.

talk2data.bioturing.com/sanofibrowser
February 27, 2025 at 5:28 PM
Reposted by Zeeba Manavi
If you are worried about science there IS something that you can do! Join us next Friday in DC to make your voice heard. Come and stand up for science! Show that science is for everyone. I’ll be there and I can’t wait to see you there too!
@standupforscience.bsky.social
February 26, 2025 at 4:31 AM
Reposted by Zeeba Manavi
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
scim.ag
February 24, 2025 at 2:59 PM
Reposted by Zeeba Manavi
Stand Up for Science rallies will be held in DC and state capitals on March 7th. Share with friends. Sign-up here to get email updates with details: www.eventbrite.com/e/stand-up-f...
STAND UP FOR SCIENCE 2025 - DC and NATIONWIDE
Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org
www.eventbrite.com
February 12, 2025 at 12:44 PM
Reposted by Zeeba Manavi
It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members.

5calls.org
February 7, 2025 at 11:37 PM
Reposted by Zeeba Manavi
Top 4 things to know about doing science:
1. You need to have someone you can talk to
2. One-on-one discussions are the best
3. Think about discussions as improvisations and use the ‘yes, and’ rule
4. Create a safe space so both of you feel open to saying seemingly silly things
January 13, 2025 at 1:52 AM
Reposted by Zeeba Manavi
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing 🧠 🕙

Incredible study 🧪 in Nature from @brunetlab.bsky.social and the Zou lab 🎉

So many intriguing findings - including that T cells have a pro-ageing proximity effect on neighbouring cells 🤯

@natureportfolio.bsky.social
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing - Nature
A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r...
www.nature.com
December 18, 2024 at 6:38 PM
Reposted by Zeeba Manavi
Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1
December 26, 2024 at 12:17 AM