Zachary Murphy
@zacharyrmurphy.bsky.social
Harvard BBS Ph.D. candidate in the Young-Pearse Lab | iPSCs and Alzheimer's Disease | Evrony Lab and Rice University 2021 alum| views are my own (he/him)
Pinned
Exciting Update: Our paper on ultra-rapid ddPCR was published today in Med (@cp-med.bsky.social)! TLDR: UR-ddPCR enables the intraoperative genotyping of tumors and quantification of tumor boundaries in 15 min from tissue --> result (open-access link in last post)
www.cell.com/med/abstract... (1/5)
www.cell.com/med/abstract... (1/5)
Reposted by Zachary Murphy
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
July 10, 2025 at 9:48 PM
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
I am honored to announce that I was chosen to be a Fujifilm Fellow through HMS's Therapeutics Graduate Program for the 2025-26 year. This year of funding will help me continue my research on the molecular and cellular roles of XX and XY chromosome complement in AD.
hms.harvard.edu/departments/...
hms.harvard.edu/departments/...
hms.harvard.edu
July 1, 2025 at 9:05 PM
I am honored to announce that I was chosen to be a Fujifilm Fellow through HMS's Therapeutics Graduate Program for the 2025-26 year. This year of funding will help me continue my research on the molecular and cellular roles of XX and XY chromosome complement in AD.
hms.harvard.edu/departments/...
hms.harvard.edu/departments/...
Reposted by Zachary Murphy
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
June 4, 2025 at 2:09 AM
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
Reposted by Zachary Murphy
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
Reposted by Zachary Murphy
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
April 11, 2025 at 11:50 PM
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
Selfie mode activated
Some members of the TYP lab had a great (and only mildly frigid) outing to Fenway to see the Red Sox play this week!
April 10, 2025 at 1:52 PM
Selfie mode activated
Reposted by Zachary Murphy
Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
April 10, 2025 at 12:15 PM
Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
Really great article by the president of Princeton! It would be great to see more universities and academic leadership band together to protect academic freedom! Maybe this will be a turning point...
www.theatlantic.com/ideas/archiv...
www.theatlantic.com/ideas/archiv...
The Cost of the Government’s Attack on Columbia
American universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.
www.theatlantic.com
March 19, 2025 at 4:53 PM
Really great article by the president of Princeton! It would be great to see more universities and academic leadership band together to protect academic freedom! Maybe this will be a turning point...
www.theatlantic.com/ideas/archiv...
www.theatlantic.com/ideas/archiv...
Reposted by Zachary Murphy
Happy to share a large part of my PhD work that is now published in Autophagy!
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are...
www.tandfonline.com
March 17, 2025 at 1:27 PM
Happy to share a large part of my PhD work that is now published in Autophagy!
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Stood up for Science today!! #StandupforScience
March 8, 2025 at 12:11 AM
Stood up for Science today!! #StandupforScience
Reposted by Zachary Murphy
Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!
February 28, 2025 at 10:16 PM
Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!
Reposted by Zachary Murphy
Online Now: Ultra-rapid droplet digital PCR enables intraoperative tumor quantification
Ultra-rapid droplet digital PCR enables intraoperative tumor quantification
Identifying a tumor’s molecular subtype during surgery and rapidly quantifying mutations in resected tissues intraoperatively could guide resection strategy and improve resections. Murphy, Bianchini, et al. introduce Ultra-Rapid droplet digital PCR, which…
dlvr.it
February 25, 2025 at 7:59 PM
Online Now: Ultra-rapid droplet digital PCR enables intraoperative tumor quantification
Exciting Update: Our paper on ultra-rapid ddPCR was published today in Med (@cp-med.bsky.social)! TLDR: UR-ddPCR enables the intraoperative genotyping of tumors and quantification of tumor boundaries in 15 min from tissue --> result (open-access link in last post)
www.cell.com/med/abstract... (1/5)
www.cell.com/med/abstract... (1/5)
February 25, 2025 at 8:02 PM
Exciting Update: Our paper on ultra-rapid ddPCR was published today in Med (@cp-med.bsky.social)! TLDR: UR-ddPCR enables the intraoperative genotyping of tumors and quantification of tumor boundaries in 15 min from tissue --> result (open-access link in last post)
www.cell.com/med/abstract... (1/5)
www.cell.com/med/abstract... (1/5)
Reposted by Zachary Murphy
HEY BOSTON! 📣☀️
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
February 21, 2025 at 6:50 PM
HEY BOSTON! 📣☀️
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
Thank you! Very excited to be done with the exam! 😅
Congratulations to PhD student @zacharyrmurphy.bsky.social for passing his preliminary exams and officially becoming a PhD candidate through the Harvard BBS program! Zack is excited to get started on his project using stem cell models to investigate sex differences in AD!
February 20, 2025 at 11:38 PM
Thank you! Very excited to be done with the exam! 😅
Reposted by Zachary Murphy
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Reposted by Zachary Murphy
How much do people around the world trust scientists?
"Most people have a relatively high trust in scientists. People want scientists to take an active role in society and policymaking."
www.nature.com/articles/s41...
"Most people have a relatively high trust in scientists. People want scientists to take an active role in society and policymaking."
www.nature.com/articles/s41...
January 23, 2025 at 4:46 AM
How much do people around the world trust scientists?
"Most people have a relatively high trust in scientists. People want scientists to take an active role in society and policymaking."
www.nature.com/articles/s41...
"Most people have a relatively high trust in scientists. People want scientists to take an active role in society and policymaking."
www.nature.com/articles/s41...
Reposted by Zachary Murphy
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 22, 2025 at 11:28 PM
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Reposted by Zachary Murphy
I lost my Biorender access since starting grad school, and it has been incredibly annoying
...but apparently the NIH launched a free, "any-use" repository of science/medical artwork called BioArt in November! It's been a great alternative so far if others are also annoyed
bioart.niaid.nih.gov
...but apparently the NIH launched a free, "any-use" repository of science/medical artwork called BioArt in November! It's been a great alternative so far if others are also annoyed
bioart.niaid.nih.gov
Bioart
bioart.niaid.nih.gov
January 13, 2025 at 2:00 AM
I lost my Biorender access since starting grad school, and it has been incredibly annoying
...but apparently the NIH launched a free, "any-use" repository of science/medical artwork called BioArt in November! It's been a great alternative so far if others are also annoyed
bioart.niaid.nih.gov
...but apparently the NIH launched a free, "any-use" repository of science/medical artwork called BioArt in November! It's been a great alternative so far if others are also annoyed
bioart.niaid.nih.gov
The Young-Pearse lab is now on Bluesky!! 🤩🧬🧠
Happy #FluorescenceFriday and inaugural bluesky post- some beautiful microglia-neuron-astrocyte co-cultures from TYP lab postdoc @heuerwego.bsky.social!
January 10, 2025 at 5:42 PM
The Young-Pearse lab is now on Bluesky!! 🤩🧬🧠
Happy New Year!!
Now, over or under 1 month until I stop accidentally writing 2024 on tubes instead of 2025 🤔😅
Now, over or under 1 month until I stop accidentally writing 2024 on tubes instead of 2025 🤔😅
January 1, 2025 at 8:20 PM
Happy New Year!!
Now, over or under 1 month until I stop accidentally writing 2024 on tubes instead of 2025 🤔😅
Now, over or under 1 month until I stop accidentally writing 2024 on tubes instead of 2025 🤔😅
Ngl the TYP lab kinda killed it this holiday season 🎄 from science elf on the shelf to Tracy's holiday party these people make science even more fun :)
December 18, 2024 at 11:05 PM
Ngl the TYP lab kinda killed it this holiday season 🎄 from science elf on the shelf to Tracy's holiday party these people make science even more fun :)
Reposted by Zachary Murphy
Created a starter pack of scientists studying sex& gender differences in biology and medicine 🧪💊 let me know if you'd like to be included go.bsky.app/CyUiL4k
November 17, 2024 at 2:17 PM
Created a starter pack of scientists studying sex& gender differences in biology and medicine 🧪💊 let me know if you'd like to be included go.bsky.app/CyUiL4k