Yuri Pritykin
@yuripritykin.bsky.social
Assistant Professor at Princeton University Lewis-Sigler Institute for Integrative Genomics (http://lsi.princeton.edu) and
Department of Computer Science (https://www.cs.princeton.edu/). Lab website: https://pritykinlab.github.io/
Department of Computer Science (https://www.cs.princeton.edu/). Lab website: https://pritykinlab.github.io/
Huge congrats to Gabe Dolsten on a fantastic PhD defense last week!!! The 1st PhD from the lab! So proud of his many research achievements e.g.:
doi.org/10.1038/s415...
doi.org/10.1101/2025...
doi.org/10.1016/j.xg...
He's bound to do amazing things ahead!
doi.org/10.1038/s415...
doi.org/10.1101/2025...
doi.org/10.1016/j.xg...
He's bound to do amazing things ahead!
November 12, 2025 at 8:55 PM
Huge congrats to Gabe Dolsten on a fantastic PhD defense last week!!! The 1st PhD from the lab! So proud of his many research achievements e.g.:
doi.org/10.1038/s415...
doi.org/10.1101/2025...
doi.org/10.1016/j.xg...
He's bound to do amazing things ahead!
doi.org/10.1038/s415...
doi.org/10.1101/2025...
doi.org/10.1016/j.xg...
He's bound to do amazing things ahead!
Happy to present today at AAI Introduction to Computational Immunology Course today at UPenn
October 18, 2025 at 3:01 PM
Happy to present today at AAI Introduction to Computational Immunology Course today at UPenn
Reposted by Yuri Pritykin
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
October 8, 2025 at 5:17 PM
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
Our paper is out today at @natimmunol.nature.com! Very timely!
We performed extensive exploration of Foxp3 in Treg cells, using inducible protein degradation in vivo.
Wonderful collaboration led by Sasha Rudensky and Wei Hu, computation led by talented Gabe Dolsten.
Read it here: rdcu.be/eJ0hH
We performed extensive exploration of Foxp3 in Treg cells, using inducible protein degradation in vivo.
Wonderful collaboration led by Sasha Rudensky and Wei Hu, computation led by talented Gabe Dolsten.
Read it here: rdcu.be/eJ0hH
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells - Nature Immunology
Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for Treg cell transcriptional and functional programs.
www.nature.com
October 8, 2025 at 11:17 AM
Our paper is out today at @natimmunol.nature.com! Very timely!
We performed extensive exploration of Foxp3 in Treg cells, using inducible protein degradation in vivo.
Wonderful collaboration led by Sasha Rudensky and Wei Hu, computation led by talented Gabe Dolsten.
Read it here: rdcu.be/eJ0hH
We performed extensive exploration of Foxp3 in Treg cells, using inducible protein degradation in vivo.
Wonderful collaboration led by Sasha Rudensky and Wei Hu, computation led by talented Gabe Dolsten.
Read it here: rdcu.be/eJ0hH
Extremely happy about the Nobel prize recognizing regulatory T cells! A fascinating concept with so many potential clinical applications.
Very lucky to have been working on the genomics of Treg cells in collaboration with the giant in the field, Sasha Rudensky @mskcc.bsky.social !
Very lucky to have been working on the genomics of Treg cells in collaboration with the giant in the field, Sasha Rudensky @mskcc.bsky.social !
October 7, 2025 at 5:11 PM
Extremely happy about the Nobel prize recognizing regulatory T cells! A fascinating concept with so many potential clinical applications.
Very lucky to have been working on the genomics of Treg cells in collaboration with the giant in the field, Sasha Rudensky @mskcc.bsky.social !
Very lucky to have been working on the genomics of Treg cells in collaboration with the giant in the field, Sasha Rudensky @mskcc.bsky.social !
Reposted by Yuri Pritykin
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
September 19, 2025 at 7:21 PM
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Reposted by Yuri Pritykin
Metadomain and metaloop genome interactions in mammalian T cells https://www.biorxiv.org/content/10.1101/2025.09.19.677419v1
September 21, 2025 at 4:34 PM
Metadomain and metaloop genome interactions in mammalian T cells https://www.biorxiv.org/content/10.1101/2025.09.19.677419v1
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
September 19, 2025 at 7:21 PM
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Reposted by Yuri Pritykin
ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories https://www.biorxiv.org/content/10.1101/2025.09.14.676182v1
September 17, 2025 at 10:36 PM
ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories https://www.biorxiv.org/content/10.1101/2025.09.14.676182v1
Happy to share our new paper!
We present high-resolution Micro-C maps across Drosophila embryogenesis, integrated with 149 ChIP-seq datasets. This systematic analysis enabled clustering of loops & boundaries into 4 distinct classes with distinct regulatory roles.
www.cell.com/cell-genomic...
We present high-resolution Micro-C maps across Drosophila embryogenesis, integrated with 149 ChIP-seq datasets. This systematic analysis enabled clustering of loops & boundaries into 4 distinct classes with distinct regulatory roles.
www.cell.com/cell-genomic...
3D chromatin structures precede genome activation in Drosophila embryogenesis
Dolsten et al. map the 3D chromatin architecture across early Drosophila development
using high-resolution Micro-C, and, by integrative analysis with 149 public ChIP-seq
datasets, identify four classe...
www.cell.com
September 16, 2025 at 7:57 PM
Happy to share our new paper!
We present high-resolution Micro-C maps across Drosophila embryogenesis, integrated with 149 ChIP-seq datasets. This systematic analysis enabled clustering of loops & boundaries into 4 distinct classes with distinct regulatory roles.
www.cell.com/cell-genomic...
We present high-resolution Micro-C maps across Drosophila embryogenesis, integrated with 149 ChIP-seq datasets. This systematic analysis enabled clustering of loops & boundaries into 4 distinct classes with distinct regulatory roles.
www.cell.com/cell-genomic...
Reposted by Yuri Pritykin
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection https://www.biorxiv.org/content/10.1101/2025.09.08.675014v1
September 14, 2025 at 4:16 AM
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection https://www.biorxiv.org/content/10.1101/2025.09.08.675014v1
Comp bio postdoc positions available! Come work with us at Princeton University on computational method development and applications in regulatory genomics, genome editing, immunology and cancer, in mouse and human: pritykinlab.github.io#jobs
Please share among all those who may be interested!
Please share among all those who may be interested!
Pritykin Lab
Pritykin Lab at the Lewis-Sigler Institute for Integrative Genomics and the Department of Computer Science at Princeton University.
pritykinlab.github.io
July 23, 2025 at 2:16 PM
Comp bio postdoc positions available! Come work with us at Princeton University on computational method development and applications in regulatory genomics, genome editing, immunology and cancer, in mouse and human: pritykinlab.github.io#jobs
Please share among all those who may be interested!
Please share among all those who may be interested!
Reposted by Yuri Pritykin
After a long trip and a long sleep, i am ready to enjoy the rich scientific program at #ISMBECCB2025 in Liverpool. This is also the first year of our new COSI in Computational and System Immunology (CSI) happening on Tuesday. And of course looking forward RegSys, as usual with fantastic organizers
July 21, 2025 at 8:29 AM
After a long trip and a long sleep, i am ready to enjoy the rich scientific program at #ISMBECCB2025 in Liverpool. This is also the first year of our new COSI in Computational and System Immunology (CSI) happening on Tuesday. And of course looking forward RegSys, as usual with fantastic organizers
Reposted by Yuri Pritykin
For CSI COSI, I am very thankful to my co-chair Jishnu Das and steering committee @yuripritykin.bsky.social, Hatice Ulku Osmanbeyoglu, Aly Azeem Khan. And everyone who submitted their for consideration for this session www.iscb.org/ismbeccb2025...
CSI: Computational Systems Immunology
ISCB - International Society for Computational Biology
www.iscb.org
July 21, 2025 at 8:29 AM
For CSI COSI, I am very thankful to my co-chair Jishnu Das and steering committee @yuripritykin.bsky.social, Hatice Ulku Osmanbeyoglu, Aly Azeem Khan. And everyone who submitted their for consideration for this session www.iscb.org/ismbeccb2025...
Reposted by Yuri Pritykin
A belated announcement about our GuideScan2 paper finally out in Genome Biology: doi.org/10.1186/s130...
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 - Genome Biology
We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA librari...
doi.org
July 8, 2025 at 5:32 PM
A belated announcement about our GuideScan2 paper finally out in Genome Biology: doi.org/10.1186/s130...
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
A belated announcement about our GuideScan2 paper finally out in Genome Biology: doi.org/10.1186/s130...
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 - Genome Biology
We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA librari...
doi.org
July 8, 2025 at 5:32 PM
A belated announcement about our GuideScan2 paper finally out in Genome Biology: doi.org/10.1186/s130...
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
GuideScan2 is a new flexible and efficient CRISPR gRNA design and analysis tool with command line and web interfaces. Please let us know what you think!
Reposted by Yuri Pritykin
Memory efficient and scalable gRNA design with GuideScan2
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 - Genome Biology
We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA librari...
genomebiology.biomedcentral.com
February 28, 2025 at 1:21 PM
Memory efficient and scalable gRNA design with GuideScan2
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Reposted by Yuri Pritykin
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 genomebiology.biomedcentral.com/a<a href="https://github.com/pritykinlab/guidescan-cli" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">rticles/10.... 🧬🖥️🧪
CLI github.com/prityki<a href="https://guidescan.com/" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">nlab/...
Web app guidescan.com
CLI github.com/prityki<a href="https://guidescan.com/" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">nlab/...
Web app guidescan.com
February 28, 2025 at 9:00 PM
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2 genomebiology.biomedcentral.com/a<a href="https://github.com/pritykinlab/guidescan-cli" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">rticles/10.... 🧬🖥️🧪
CLI github.com/prityki<a href="https://guidescan.com/" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">nlab/...
Web app guidescan.com
CLI github.com/prityki<a href="https://guidescan.com/" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">nlab/...
Web app guidescan.com
Reposted by Yuri Pritykin
Our ChromBPNet preprint out!
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
December 25, 2024 at 11:48 PM
Our ChromBPNet preprint out!
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
Excited to host @jianma.bsky.social today
at Princeton CS and looking forward to his talk:
cs.princeton.edu/events/26752
Come to CS 105 at 12:30 today if you are around!
at Princeton CS and looking forward to his talk:
cs.princeton.edu/events/26752
Come to CS 105 at 12:30 today if you are around!
Learning Multiscale Genome and Cellular Organization | Computer Science Department at Princeton University
cs.princeton.edu
December 3, 2024 at 2:07 PM
Excited to host @jianma.bsky.social today
at Princeton CS and looking forward to his talk:
cs.princeton.edu/events/26752
Come to CS 105 at 12:30 today if you are around!
at Princeton CS and looking forward to his talk:
cs.princeton.edu/events/26752
Come to CS 105 at 12:30 today if you are around!