Yaw Shin
@yawshinooi.bsky.social
Assistant Professor of Emerging Infectious Diseases,
Duke-NUS Medical School, Singapore.
Adj. Investigator, A*STAR Infectious Diseases Labs
#CellBiologyofVirusInfection
#FunctionalGenomics
https://sites.google.com/view/ysolab
Duke-NUS Medical School, Singapore.
Adj. Investigator, A*STAR Infectious Diseases Labs
#CellBiologyofVirusInfection
#FunctionalGenomics
https://sites.google.com/view/ysolab
Pinned
Yaw Shin
@yawshinooi.bsky.social
· Nov 28
A review of virus host factor discovery using CRISPR screening | mBio
All viruses depend on host cell machinery to complete their infection cycle for their
survival. The intricate interactions between viruses and their host cells are not
one-way processes. Hosts have co...
journals.asm.org
Reposted by Yaw Shin
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 6:26 PM
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Yaw Shin
De novo recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus https://www.biorxiv.org/content/10.1101/2025.10.08.679836v1
October 9, 2025 at 2:16 AM
De novo recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus https://www.biorxiv.org/content/10.1101/2025.10.08.679836v1
Reposted by Yaw Shin
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Cracking the Code: Nucleic Acid Medicines Coming of Age
The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...
natureconferences.streamgo.live
September 30, 2025 at 7:45 PM
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Reposted by Yaw Shin
Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment
go.nature.com/3Kqp5E9
go.nature.com/3Kqp5E9
How a tick-borne virus enters human cells
Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.
go.nature.com
September 25, 2025 at 7:49 AM
Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment
go.nature.com/3Kqp5E9
go.nature.com/3Kqp5E9
Reposted by Yaw Shin
This week on the pod:
🧠 New insights into tick-borne encephalitis
🔬 How might cancelled NIH grants affect the future of US science?
go.nature.com/42IRtrn
🧠 New insights into tick-borne encephalitis
🔬 How might cancelled NIH grants affect the future of US science?
go.nature.com/42IRtrn
How a dangerous tick-borne virus sneaks into the brain
Hear the biggest stories from the world of science | 24 September 2025
go.nature.com
September 25, 2025 at 11:01 AM
This week on the pod:
🧠 New insights into tick-borne encephalitis
🔬 How might cancelled NIH grants affect the future of US science?
go.nature.com/42IRtrn
🧠 New insights into tick-borne encephalitis
🔬 How might cancelled NIH grants affect the future of US science?
go.nature.com/42IRtrn
Reposted by Yaw Shin
Ebola outbreak in the Democratic Republic of Congo is a warning
-by @krutikakuppalli.bsky.social
www.statnews.com/2025/09/11/e...
-by @krutikakuppalli.bsky.social
www.statnews.com/2025/09/11/e...
Ebola outbreak in the Democratic Republic of Congo is a warning
“Ebola is never just a virus; it is a mirror,” writes infectious disease physician Krutika Kuppalli.
www.statnews.com
September 12, 2025 at 6:36 AM
Ebola outbreak in the Democratic Republic of Congo is a warning
-by @krutikakuppalli.bsky.social
www.statnews.com/2025/09/11/e...
-by @krutikakuppalli.bsky.social
www.statnews.com/2025/09/11/e...
Reposted by Yaw Shin
Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
September 8, 2025 at 8:02 AM
Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
Reposted by Yaw Shin
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Yaw Shin
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Tenthorey et al. compare the effects of missense and indel mutations on the acquisition
of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find
that single indel mutations al...
www.cell.com
March 27, 2025 at 9:36 PM
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Yaw Shin
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
March 26, 2025 at 5:40 PM
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Awesome Power of Genetic Screening! Honored to be part of this wonderful discovery—MFSD6 is an entry receptor for Enterovirus D68!
March 27, 2025 at 1:07 AM
Awesome Power of Genetic Screening! Honored to be part of this wonderful discovery—MFSD6 is an entry receptor for Enterovirus D68!
Reposted by Yaw Shin
Once upon a time, in the late 1800s, people in Japan got really into breeding mice.
Coloured mice. Patterned mice. Even mice that danced.
They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study.
2/n
Coloured mice. Patterned mice. Even mice that danced.
They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study.
2/n
March 4, 2025 at 3:10 PM
Once upon a time, in the late 1800s, people in Japan got really into breeding mice.
Coloured mice. Patterned mice. Even mice that danced.
They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study.
2/n
Coloured mice. Patterned mice. Even mice that danced.
They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study.
2/n
Reposted by Yaw Shin
Today's @usatoday.com front page
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
February 27, 2025 at 2:09 PM
Today's @usatoday.com front page
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
Reposted by Yaw Shin
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 21, 2025 at 5:31 PM
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
Reposted by Yaw Shin
Check out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social
cellsurfacemap.org
cellsurfacemap.org
Cell Surface Map
Cell Surface Map - Distribution and organization data on immune cell surface proteins
cellsurfacemap.org
February 21, 2025 at 1:56 AM
Check out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social
cellsurfacemap.org
cellsurfacemap.org
Reposted by Yaw Shin
Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT
apple.news/APlQhGHRrSfy...
apple.news/APlQhGHRrSfy...
Graduate student admissions paused and cut back as universities react to Trump orders on research — STAT
Acceptances for biomedical graduate students and postdoctoral scholars are being cut back at some universities and medical centers across the country as many grapple with the potential impact of the T...
apple.news
February 20, 2025 at 2:04 AM
Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT
apple.news/APlQhGHRrSfy...
apple.news/APlQhGHRrSfy...
Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 19, 2025 at 5:46 PM
Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Presented our #Henipavirus works at the #Hendra@30 meeting in Geelong, Victoria, Australia. Wonderful conference! Bonus—get to meet and know fellow Malaysian virologists/microbiologists!
December 12, 2024 at 11:43 AM
Presented our #Henipavirus works at the #Hendra@30 meeting in Geelong, Victoria, Australia. Wonderful conference! Bonus—get to meet and know fellow Malaysian virologists/microbiologists!
Reposted by Yaw Shin
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
journals.biologists.com
December 2, 2024 at 9:19 AM
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Reposted by Yaw Shin
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
November 10, 2024 at 2:43 PM
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
Reposted by Yaw Shin
Anybody studying bat viruses and immunology knows there aren’t enough publicly available resources. You can only buy 3 bat cell lines at the moment and they aren’t suitable for many viruses. The first bat cell line was deposited with ATCC in 1967, btw.
Link: tinyurl.com/53nvxkyx
Link: tinyurl.com/53nvxkyx
Viral susceptibility and innate immune competency of Carollia perspicillata bat cells produced for virological studies
Multiple viruses that are highly pathogenic in humans are known to have evolved in bats. How bats tolerate infection with these viruses, however, is poorly understood. As viruses engage in a wide rang...
tinyurl.com
November 20, 2024 at 4:36 PM
Anybody studying bat viruses and immunology knows there aren’t enough publicly available resources. You can only buy 3 bat cell lines at the moment and they aren’t suitable for many viruses. The first bat cell line was deposited with ATCC in 1967, btw.
Link: tinyurl.com/53nvxkyx
Link: tinyurl.com/53nvxkyx