Vikas Yadav
@vikasyadavsci.bsky.social
Molecular microbiologist studying fungal genome dynamics, cell biology, and pathogenicity using Cryptococcus.
Senior Research Associate at Duke. Alumnus of JNCASR, India.
https://scholars.duke.edu/person/vikas.yadav
Senior Research Associate at Duke. Alumnus of JNCASR, India.
https://scholars.duke.edu/person/vikas.yadav
Reposted by Vikas Yadav
Extremely excited to present our latest preprint in which we mapped a thermoregulation network that governs virulence in a human fungal pathogen through genetic suppressors, TurboID proximity ligation assay, and functional regulation via domain-truncation alleles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 20, 2025 at 3:00 AM
Extremely excited to present our latest preprint in which we mapped a thermoregulation network that governs virulence in a human fungal pathogen through genetic suppressors, TurboID proximity ligation assay, and functional regulation via domain-truncation alleles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Extremely excited to present our latest preprint in which we mapped a thermoregulation network that governs virulence in a human fungal pathogen through genetic suppressors, TurboID proximity ligation assay, and functional regulation via domain-truncation alleles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 20, 2025 at 3:00 AM
Extremely excited to present our latest preprint in which we mapped a thermoregulation network that governs virulence in a human fungal pathogen through genetic suppressors, TurboID proximity ligation assay, and functional regulation via domain-truncation alleles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vikas Yadav
Today is a good day to read our preprint about Candida albicans interactions with its neighbors! www.biorxiv.org/content/10.1... led by the amazing Faith Davis and a fantastic team of collaborators @kylaost.bsky.social @shannonrighi.bsky.social @balunaslab.bsky.social @tuowang.bsky.social
Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi
The fungus Candida albicans commensally colonizes mucosal surfaces in healthy individuals but can cause both superficial mucosal and life-threatening disseminated infections. The balance between comme...
www.biorxiv.org
July 28, 2025 at 2:04 PM
Today is a good day to read our preprint about Candida albicans interactions with its neighbors! www.biorxiv.org/content/10.1... led by the amazing Faith Davis and a fantastic team of collaborators @kylaost.bsky.social @shannonrighi.bsky.social @balunaslab.bsky.social @tuowang.bsky.social
Reposted by Vikas Yadav
The story behind the science…that began like 30 years ago! A reminder to undergrad researchers to keep good notebooks (and freezer logs)! :)
Excited to share my latest paper on the role of calcineurin in cytokinesis in a critical human pathogen. It started with a genetic screen to identify mutants that can provide resistance to calcineurin inhibitors, which took us to a very unexpected place. A short 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 24, 2025 at 4:48 PM
The story behind the science…that began like 30 years ago! A reminder to undergrad researchers to keep good notebooks (and freezer logs)! :)
Elated to share that this story about an unexpected and important finding is now published @pnas.org
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
May 24, 2025 at 4:36 PM
Elated to share that this story about an unexpected and important finding is now published @pnas.org
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
Reposted by Vikas Yadav
Vikas Yadav @vikasyadavsci.bsky.social closes out the first session by exploring how Calcineurin drives thermal adaptation in Cryptococcus
May 16, 2025 at 2:34 PM
Vikas Yadav @vikasyadavsci.bsky.social closes out the first session by exploring how Calcineurin drives thermal adaptation in Cryptococcus
Reposted by Vikas Yadav
Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans https://www.biorxiv.org/content/10.1101/2025.02.17.638697v1
February 21, 2025 at 1:33 PM
Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans https://www.biorxiv.org/content/10.1101/2025.02.17.638697v1
Excited to share my latest paper on the role of calcineurin in cytokinesis in a critical human pathogen. It started with a genetic screen to identify mutants that can provide resistance to calcineurin inhibitors, which took us to a very unexpected place. A short 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 21, 2025 at 4:12 PM
Excited to share my latest paper on the role of calcineurin in cytokinesis in a critical human pathogen. It started with a genetic screen to identify mutants that can provide resistance to calcineurin inhibitors, which took us to a very unexpected place. A short 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A postdoc position in fungal pathogenesis and drug resistance mechanisms is available at the University of Arkansas for Medical Sciences in the labs of Bill Steinbach and Praveen Juvvadi. Details here:
November 27, 2024 at 5:30 PM
A postdoc position in fungal pathogenesis and drug resistance mechanisms is available at the University of Arkansas for Medical Sciences in the labs of Bill Steinbach and Praveen Juvvadi. Details here:
Reposted by Vikas Yadav
The Medical Mycology Trainee Seminar Series is back! Our next seminar is November 14th at 4 pm GMT (5 pm Central Europe Time, 11 am Eastern Standard, 8 am Pacific Standard, 12 am in China). 1/12
November 12, 2024 at 6:57 AM
The Medical Mycology Trainee Seminar Series is back! Our next seminar is November 14th at 4 pm GMT (5 pm Central Europe Time, 11 am Eastern Standard, 8 am Pacific Standard, 12 am in China). 1/12
A beautiful study that highlights SO MUCH about genome structure evolution with implications on the evolution of pathogenicity. Amazing piece of work led by
Marco and Marcia in the Heitman lab in collaboration with Christina Cuomo's team.
It comes with the most beautiful figures.
t.co/XQj3KLykmv
Marco and Marcia in the Heitman lab in collaboration with Christina Cuomo's team.
It comes with the most beautiful figures.
t.co/XQj3KLykmv
Comparative genomics of the closely related fungal genera Cryptococcus and Kwoniella reveals karyotype dynamics and suggests evolutionary mechanisms of pathogenesis
Understanding the different evolution of closely related pathogenic and non-pathogenic fungi can help decipher the mechanisms of pathogenesis. In this study, comparative genomics is used to analyze th...
t.co
June 7, 2024 at 1:46 PM
A beautiful study that highlights SO MUCH about genome structure evolution with implications on the evolution of pathogenicity. Amazing piece of work led by
Marco and Marcia in the Heitman lab in collaboration with Christina Cuomo's team.
It comes with the most beautiful figures.
t.co/XQj3KLykmv
Marco and Marcia in the Heitman lab in collaboration with Christina Cuomo's team.
It comes with the most beautiful figures.
t.co/XQj3KLykmv
Our new paper describing an unexpected role of #calcineurin signaling in #RNAi-mediated small RNA production is now out in GENETICS - implying a way to quickly adapt to external conditions by altering gene expression levels. #Fungi #Cryptococcus
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
January 31, 2024 at 10:40 AM
Our new paper describing an unexpected role of #calcineurin signaling in #RNAi-mediated small RNA production is now out in GENETICS - implying a way to quickly adapt to external conditions by altering gene expression levels. #Fungi #Cryptococcus
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Interested in chromosome number or centromere structure evolution? Giant chromosomes and mini-chromosomes? Pathogenicity-specific horizontal gene transfer? Find all these and more in this massive piece of work led by Marco and Marcia (Heitman lab) with Christina Cuomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 3, 2024 at 4:37 PM
Interested in chromosome number or centromere structure evolution? Giant chromosomes and mini-chromosomes? Pathogenicity-specific horizontal gene transfer? Find all these and more in this massive piece of work led by Marco and Marcia (Heitman lab) with Christina Cuomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...