Tommaso Patriarchi
@tpatriarchi.bsky.social
Assistant Prof. at UZH 🇨🇭 | protein engineering for pharmacology and neuroscience | opinions my own
Reposted by Tommaso Patriarchi
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable
lifetimes across the visible spectrum enables simultaneous multiplexed live imaging,
super-resolution microscopy, a...
www.cell.com
September 26, 2025 at 8:07 AM
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Congrats Martin, great work!
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 28, 2025 at 7:09 AM
Congrats Martin, great work!
Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.
I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days
The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...
www.biorxiv.org
June 6, 2025 at 10:30 AM
Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.
Reposted by Tommaso Patriarchi
#BlueskyResistance #Voices4Victory #ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…
Advertisement at a London bus stop. Ya gotta love the British…
February 24, 2025 at 2:58 PM
#BlueskyResistance #Voices4Victory #ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…
Advertisement at a London bus stop. Ya gotta love the British…
Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
www.nature.com
February 20, 2025 at 4:55 PM
Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!
Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!
February 10, 2025 at 11:17 AM
Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!
Amazing work by @massecklab.bsky.social PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...
December 18, 2024 at 10:52 AM
Amazing work by @massecklab.bsky.social PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this
Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)
December 13, 2024 at 8:23 AM
Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)
Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks
December 13, 2024 at 8:16 AM
Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks
This is really fascinating work, congrats to the whole team!
with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 5, 2024 at 12:12 PM
This is really fascinating work, congrats to the whole team!
Reposted by Tommaso Patriarchi
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
December 1, 2024 at 8:29 PM
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)