Tony Martini
@tmartini.bsky.social
Regular Human Microbiologist | Bacterial Physiology & Pathogenesis | Polymicrobial Infection Models w/ S. aureus, P. aeruginosa, S. sanguinis, and more | Postdoc @ NIH, Khare Lab | Board Games & TRPGs | Tennis | Metalhead | Seinfeld
Reposted by Tony Martini
Stenotrophomonas maltophilia exhibits defensive multicellularity in response to a Pseudomonas aeruginosa quorum sensing molecule https://www.biorxiv.org/content/10.1101/2025.05.02.651457v1
May 3, 2025 at 5:17 AM
Stenotrophomonas maltophilia exhibits defensive multicellularity in response to a Pseudomonas aeruginosa quorum sensing molecule https://www.biorxiv.org/content/10.1101/2025.05.02.651457v1
Reposted by Tony Martini
Our review on Z-ring placement mechanisms in cocci is out! This was a fun one to write!
#Microsky 🦠🧫
#Microsky 🦠🧫
Cell division in rod-shaped bacteria is well studied (think "Min system"), but how do round bacteria find their middle? @felixrl.bsky.social 's new review article covers how #Staph aureus, Streptococci, and others figure out how to perform binary fission.
portlandpress.com/biochemsoctr...
portlandpress.com/biochemsoctr...
How do spherical bacteria regulate cell division?
Many bacteria divide by binary fission, producing two identical daughter cells, which requires proper placement of the division machinery at mid-cell. Spherical bacteria (cocci) face unique challenges...
portlandpress.com
April 22, 2025 at 3:14 PM
Our review on Z-ring placement mechanisms in cocci is out! This was a fun one to write!
#Microsky 🦠🧫
#Microsky 🦠🧫
Reposted by Tony Martini
Excited to share this new preprint from the lab, where postdoc Pavan Silva @kptsilva.bsky.social found pathways that control gene amplifications, and thus antibiotic resistance, in Staph aureus!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Genetic determinants of gene amplifications alter frequency and evolutionary trajectory of antibiotic resistance in Staphylococcus aureus
Gene amplifications are thought to be common in bacterial populations, providing a rapid reversible mode of adaptation to diverse stresses, including the acquisition of antibiotic resistance. We previ...
www.biorxiv.org
April 12, 2025 at 9:08 PM
Excited to share this new preprint from the lab, where postdoc Pavan Silva @kptsilva.bsky.social found pathways that control gene amplifications, and thus antibiotic resistance, in Staph aureus!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We are now live at PLoS Genetics! Thanks to the editors and reviewers for their work and suggestions to improve the paper!
March 7, 2025 at 6:50 PM
We are now live at PLoS Genetics! Thanks to the editors and reviewers for their work and suggestions to improve the paper!
Reposted by Tony Martini
@asm.org this better not be anticipatory obedience. I have 5 lab members planning on going to ASM microbe this year. I will absolutely pivot to another meeting if ASM gives in to anti-DEI efforts.
@vscooper.micropopbio.org and @mostlymicrobes.bsky.social while downloading scientist spotlights for teaching from the site; ASM has also scrubbed the entire IDEAA page including resources on LGBTQ+ scientists at asm.org/IDEAA/resources/pride-month
February 2, 2025 at 6:30 PM
@asm.org this better not be anticipatory obedience. I have 5 lab members planning on going to ASM microbe this year. I will absolutely pivot to another meeting if ASM gives in to anti-DEI efforts.
Reposted by Tony Martini
Just to be clear: Lyme was discovered by a CDC scientist investigating what was thought to be a cluster of juvenile rheumatoid arthritis cases in Lyme CT. It is not a bioweapon, but him saying it will ABSOLUTELY lead to people coming to me and other ID docs asking for testing/treatment 🙄🤦🏻♂️
Brutal exchange between RFK Jr. and Sen. Bennet:
Bennet: Did you say Lyme disease is a highly likely militarily engineered bioweapon?
Kennedy: I probably did say that.
Bennet: Did you say Lyme disease is a highly likely militarily engineered bioweapon?
Kennedy: I probably did say that.
January 29, 2025 at 11:42 PM
Just to be clear: Lyme was discovered by a CDC scientist investigating what was thought to be a cluster of juvenile rheumatoid arthritis cases in Lyme CT. It is not a bioweapon, but him saying it will ABSOLUTELY lead to people coming to me and other ID docs asking for testing/treatment 🙄🤦🏻♂️
Reposted by Tony Martini
Very important paper out by George Liu's team in JCI this week: "Pathobiont-driven antibody sialylation through IL-10 undermines vaccination" www.jci.org/articles/vie...
Here is my commentary on it: www.jci.org/articles/vie...
Here is my commentary on it: www.jci.org/articles/vie...
JCI -
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
www.jci.org
December 18, 2024 at 5:18 PM
Very important paper out by George Liu's team in JCI this week: "Pathobiont-driven antibody sialylation through IL-10 undermines vaccination" www.jci.org/articles/vie...
Here is my commentary on it: www.jci.org/articles/vie...
Here is my commentary on it: www.jci.org/articles/vie...
Reposted by Tony Martini
🚨 PhD opportunity 🚨 The Whelan lab, along w @brockhurstlab.bsky.social, are looking for a PhD student w bioinformatic experience/interest to investigate the evolution of transmissibility in bacterial pathogens, with a focus on P. aeruginosa. More info & link to apply below.
Please spread the word!
Please spread the word!
www.findaphd.com
December 3, 2024 at 12:49 PM
🚨 PhD opportunity 🚨 The Whelan lab, along w @brockhurstlab.bsky.social, are looking for a PhD student w bioinformatic experience/interest to investigate the evolution of transmissibility in bacterial pathogens, with a focus on P. aeruginosa. More info & link to apply below.
Please spread the word!
Please spread the word!
Reposted by Tony Martini
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
November 18, 2024 at 4:38 PM
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Tony Martini
SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜
Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice
Nature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...
rdcu.be
November 15, 2024 at 4:46 PM
SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜
Happy to share our newest preprint from @anukharelab.bsky.social and my first postdoc project: biorxiv.org/content/10.1.... Here, we characterized how S. aureus adapts to pyocyanin, an antimicrobial produced by P. aeruginosa. This project was started by...
Mutations in the Staphylococcus aureus Global Regulator CodY Confer Tolerance to an Interspecies Redox-Active Antimicrobial
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
July 5, 2024 at 3:27 PM
Happy to share our newest preprint from @anukharelab.bsky.social and my first postdoc project: biorxiv.org/content/10.1.... Here, we characterized how S. aureus adapts to pyocyanin, an antimicrobial produced by P. aeruginosa. This project was started by...