The Thoughtful Intensivist
@thethoughtfulintensivist.skystack.xyz
Insightful criticism of current critical care research
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This is an automated Substack Account of https://thethoughtfulintensivist.substack.com
Discover more/Create at: @skystack.xyz
The Flag of Permanent Defeat • Epistemic Crisis and Failure in Sepsis Research
The Flag of Permanent Defeat
Epistemic Crisis and Failure in Sepsis Research
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
The Flag of Permanent Defeat • Epistemic Crisis and Failure in Sepsis Research
Can we drive immunity back into homeostasis? • The guys from TIGRIS think we can.
Can we drive immunity back into homeostasis?
The guys from TIGRIS think we can.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Can we drive immunity back into homeostasis? • The guys from TIGRIS think we can.
Precision Critical Care? • Don't mistake P-fishing for precision medicine.
Precision Critical Care?
Don't mistake P-fishing for precision medicine.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Precision Critical Care? • Don't mistake P-fishing for precision medicine.
Marik and the rise of Alternative Critical Care • Academic critical care is becoming indistinguishable from alternative medicine
Marik and the rise of Alternative Critical Care
Academic critical care is becoming indistinguishable from alternative medicine
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Marik and the rise of Alternative Critical Care • Academic critical care is becoming indistinguishable from alternative medicine
The PPI-Sepsis study is a mistake we must never repeat • The world's first translational review discussing the causal assumptions.
The PPI-Sepsis study is a mistake we must never repeat
The world's first translational review discussing the causal assumptions.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
The PPI-Sepsis study is a mistake we must never repeat • The world's first translational review discussing the causal assumptions.
Problems with the Causal Inference & Bayesian fads
Problems with the Causal Inference & Bayesian fads
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Problems with the Causal Inference & Bayesian fads
Thresholds-based definitions introduced bias into critical care research • A short paper
Thresholds-based definitions introduced bias into critical care research
A short paper
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Thresholds-based definitions introduced bias into critical care research • A short paper
Medicine - State of the art # 03 - On disease causes
Medicine - State of the art # 03 - On disease causes
argolostudio.substack.com
November 24, 2025 at 1:17 PM
Medicine - State of the art # 03 - On disease causes
How do we mistake biological plausibility for clinical relevance? • The case for Blindness to Marginal Utility
How do we mistake biological plausibility for clinical relevance?
The case for Blindness to Marginal Utility
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
How do we mistake biological plausibility for clinical relevance? • The case for Blindness to Marginal Utility
Artificial Intelligence Delusion
Artificial Intelligence Delusion
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Artificial Intelligence Delusion
Escalophobesis
Escalophobesis
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Escalophobesis
Dr Bellomo passed away. What is his legacy? • Esomeprazole for sepsis?
Dr Bellomo passed away. What is his legacy?
Esomeprazole for sepsis?
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Dr Bellomo passed away. What is his legacy? • Esomeprazole for sepsis?
(part two) Predicting the results of CCR 2025 trials • PROMIZING, TARGET, and UK-ROX.
(part two) Predicting the results of CCR 2025 trials
PROMIZING, TARGET, and UK-ROX.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
(part two) Predicting the results of CCR 2025 trials • PROMIZING, TARGET, and UK-ROX.
Predicting the results of CCR 2025 Trials • FLUID and PRINCE
Predicting the results of CCR 2025 Trials
FLUID and PRINCE
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Predicting the results of CCR 2025 Trials • FLUID and PRINCE
Professor Angus is wrong • A pile of wrong assumptions about sepsis just wrecked.
Professor Angus is wrong
A pile of wrong assumptions about sepsis just wrecked.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Professor Angus is wrong • A pile of wrong assumptions about sepsis just wrecked.
A dive in plausibility preceded by three insights • All four motivated by a Critical Care Medicine issue
A dive in plausibility preceded by three insights
All four motivated by a Critical Care Medicine issue
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
A dive in plausibility preceded by three insights • All four motivated by a Critical Care Medicine issue
REMAP-CAP delivered a science-mimic • I don't know about you, but I am tired of Prof Annane's corticosteroid studies.
REMAP-CAP delivered a science-mimic
I don't know about you, but I am tired of Prof Annane's corticosteroid studies.
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
REMAP-CAP delivered a science-mimic • I don't know about you, but I am tired of Prof Annane's corticosteroid studies.
Science Monopoly • A call to reform critical care science
Science Monopoly
A call to reform critical care science
thethoughtfulintensivist.substack.com
November 24, 2025 at 1:17 PM
Science Monopoly • A call to reform critical care science