Chris Sullivan
@sullivanlab.bsky.social
Virologist at UT Austin who works on host- pathogen interactions and RNA.
Reposted by Chris Sullivan
🚨Preprint alert! Kind of a late notice, but here is our latest work on bat Dicer and viral infection. Work led by @leagaucherand.bsky.social and Hugo Marie in the lab. @cnrsbiologie.bsky.social @unistra.fr @frm-officiel.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells
Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite a...
www.biorxiv.org
July 28, 2025 at 2:08 PM
🚨Preprint alert! Kind of a late notice, but here is our latest work on bat Dicer and viral infection. Work led by @leagaucherand.bsky.social and Hugo Marie in the lab. @cnrsbiologie.bsky.social @unistra.fr @frm-officiel.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
If anyone is at #RNA2025, please stop by my lab’s posters on triphosphate balance and virus infection and tracking persistent infection with precision to identify viral miRNA functions.
Authors Szymanik and Mojumder are really great and are presenting in the second session this Friday from 8-10.
Authors Szymanik and Mojumder are really great and are presenting in the second session this Friday from 8-10.
May 28, 2025 at 4:23 PM
If anyone is at #RNA2025, please stop by my lab’s posters on triphosphate balance and virus infection and tracking persistent infection with precision to identify viral miRNA functions.
Authors Szymanik and Mojumder are really great and are presenting in the second session this Friday from 8-10.
Authors Szymanik and Mojumder are really great and are presenting in the second session this Friday from 8-10.
Small DNA viruses can concurrently shed via two different patterns: continuous low-level shedding of numerous reservoirs and punctuated rare high shedding from one or a few reservoirs.
We hope tools presented here are useful to study other persistent pathogens.
journals.plos.org/plospathogen...
We hope tools presented here are useful to study other persistent pathogens.
journals.plos.org/plospathogen...
Shedding dynamics of a DNA virus population during acute and long-term persistent infection
Author Summary/ Importance Polyomavirus infections, mostly benign but potentially fatal for immunocompromised individuals, undergo acute and long-term persistent infections. Typically, polyomavirus-as...
journals.plos.org
May 23, 2025 at 8:52 PM
Small DNA viruses can concurrently shed via two different patterns: continuous low-level shedding of numerous reservoirs and punctuated rare high shedding from one or a few reservoirs.
We hope tools presented here are useful to study other persistent pathogens.
journals.plos.org/plospathogen...
We hope tools presented here are useful to study other persistent pathogens.
journals.plos.org/plospathogen...
Reposted by Chris Sullivan
Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila
Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.
www.science.org
May 20, 2025 at 2:47 PM
Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Reposted by Chris Sullivan
Newest: Virologs mark #RNA metabolism as an evolutionary battleground during infection - Great collaboration w/@sullivanlab.bsky.social & Kayla Szymanik @plos.org journals.plos.org/plospathogen...
Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
journals.plos.org
May 6, 2025 at 6:50 PM
Newest: Virologs mark #RNA metabolism as an evolutionary battleground during infection - Great collaboration w/@sullivanlab.bsky.social & Kayla Szymanik @plos.org journals.plos.org/plospathogen...
Reposted by Chris Sullivan
New Resource Article:
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
March 3, 2025 at 5:32 PM
New Resource Article:
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
Reposted by Chris Sullivan
Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
dx.plos.org
April 22, 2025 at 4:19 PM
Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity.
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
journals.plos.org
April 22, 2025 at 1:22 PM
Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity.
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Happy to share our manuscript showing that a small DNA virus can concurrently shed via two different patterns: continuous low-level shedding of numerous reservoirs and punctuated rare high shedding from one or a few reservoirs.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Shedding dynamics of a DNA virus population during acute and long-term persistent infection
Although much is known of the molecular mechanisms of virus infection within cells, substantially less is understood about within-host infection. Such knowledge is key to understanding how viruses tak...
www.biorxiv.org
April 7, 2025 at 7:44 PM
Happy to share our manuscript showing that a small DNA virus can concurrently shed via two different patterns: continuous low-level shedding of numerous reservoirs and punctuated rare high shedding from one or a few reservoirs.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...