Sourik Dey
@sourikdey.bsky.social
Microbiome Engineer | Cleveland Clinic Lerner Research Institute | PhD in Synthetic Biology | Leibniz-INM, Germany | IIT Roorkee | St. Xavier's College, Kolkata
Pinned
Sourik Dey
@sourikdey.bsky.social
· Nov 20
Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic - Journal of Biological Engineering
Peptide drugs have seen rapid advancement in biopharmaceutical development, with over 80 candidates approved globally. Despite their therapeutic potential, the clinical translation of peptide drugs is...
link.springer.com
Excited to share our latest work on developing genetic circuits for temperature regulated antibiotic production. Thanks to my colleagues from Helmholtz_HIPS and Leibniz_INM, and LSCLifeMat for the funding.
#synbio #microbiology
Link to the paper 👉👉 -
link.springer.com/article/10.1...
#synbio #microbiology
Link to the paper 👉👉 -
link.springer.com/article/10.1...
Excited to launch my postdoc at the Cleveland Clinic Lerner Research Institute! 🧪 In Prof. Dwidar’s lab, I’m harnessing bacterial synthetic biology 🦠to pioneer new therapeutics and shape the future of precision medicine. Let’s do this! 🚀#synbio #PostdocJourney #ClevelandClinic
July 1, 2025 at 1:46 AM
Excited to launch my postdoc at the Cleveland Clinic Lerner Research Institute! 🧪 In Prof. Dwidar’s lab, I’m harnessing bacterial synthetic biology 🦠to pioneer new therapeutics and shape the future of precision medicine. Let’s do this! 🚀#synbio #PostdocJourney #ClevelandClinic
Reposted by Sourik Dey
Wow: Plastic → Tylenol? 🧪♻️💊
A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli
Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions
Stunning blend of chemistry and synthetic biology
www.nature.com/articles/s41...
A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli
Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions
Stunning blend of chemistry and synthetic biology
www.nature.com/articles/s41...
A biocompatible Lossen rearrangement in Escherichia coli - Nature Chemistry
Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...
www.nature.com
June 23, 2025 at 3:45 PM
Wow: Plastic → Tylenol? 🧪♻️💊
A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli
Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions
Stunning blend of chemistry and synthetic biology
www.nature.com/articles/s41...
A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli
Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions
Stunning blend of chemistry and synthetic biology
www.nature.com/articles/s41...
When academics say industries were running after them for recruitment, but they chose a path of passion instead!
How academics imagine their lives would look like if they decide to work in tech
May 15, 2025 at 4:13 PM
When academics say industries were running after them for recruitment, but they chose a path of passion instead!
Reposted by Sourik Dey
The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria
Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops.
www.npr.org/2025/05/14/n...
Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops.
www.npr.org/2025/05/14/n...
The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria
This year's $500,000 World Food Prize, for advances in agriculture and nutrition, goes to a Brazilian who boosted the country's farming revolution, turning it into a soybean superpower.
www.npr.org
May 15, 2025 at 2:14 PM
The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria
Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops.
www.npr.org/2025/05/14/n...
Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops.
www.npr.org/2025/05/14/n...
Reposted by Sourik Dey
Excited to share our latest work, published in a peer-reviewed journal. We studied how Gram +/- probiotic bacteria would adapt in mechanical confinements - key part in understanding the fundamentals of Engineered living materials. Read it here:
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Adaptations of Gram-Negative and Gram-Positive Probiotic Bacteria in Engineered Living Materials
Encapsulation of microbes in natural or synthetic matrices is a key aspect of engineered living materials, although the influence of such confinement on microbial behavior is poorly understood. A few ...
pubs.acs.org
May 14, 2025 at 10:50 PM
Excited to share our latest work, published in a peer-reviewed journal. We studied how Gram +/- probiotic bacteria would adapt in mechanical confinements - key part in understanding the fundamentals of Engineered living materials. Read it here:
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Sourik Dey
Finally, access to a pichia pastoris strain. Time to adapt it enough to become a truly open strain, without the $5000 buy in of the current "open" version. Worst case $20/stab and zero MTA. Evolved with love. Big thanks to @koeng101 off Twitter for sourcing! 💚
April 14, 2025 at 6:26 PM
Finally, access to a pichia pastoris strain. Time to adapt it enough to become a truly open strain, without the $5000 buy in of the current "open" version. Worst case $20/stab and zero MTA. Evolved with love. Big thanks to @koeng101 off Twitter for sourcing! 💚
Reposted by Sourik Dey
Article (paywalled) about our pre-print discussing Bioengineered journal’s paper mill problem: www.nature.com/articles/d41...
arxiv.org/abs/2503.21267
Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social
for letting me tag along!
arxiv.org/abs/2503.21267
Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social
for letting me tag along!
April 3, 2025 at 10:40 PM
Article (paywalled) about our pre-print discussing Bioengineered journal’s paper mill problem: www.nature.com/articles/d41...
arxiv.org/abs/2503.21267
Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social
for letting me tag along!
arxiv.org/abs/2503.21267
Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social
for letting me tag along!
Reposted by Sourik Dey
Lol I have A LOT of work to do before I get even remotely close to the level of protein expression a well designed plasmid can generate. This is pCambia2300 expressing the same RFP circuit (albeit in Agrobacterium; left) and my single copy transposon integration in BL21 Ecoli (right).
March 26, 2025 at 2:29 PM
Lol I have A LOT of work to do before I get even remotely close to the level of protein expression a well designed plasmid can generate. This is pCambia2300 expressing the same RFP circuit (albeit in Agrobacterium; left) and my single copy transposon integration in BL21 Ecoli (right).
Reposted by Sourik Dey
From the hasty lab:
Evolved microbial diversity enables combinatoric biosensing in complex environments
doi.org/10.1101/2025...
Evolved microbial diversity enables combinatoric biosensing in complex environments
doi.org/10.1101/2025...
March 26, 2025 at 5:37 PM
From the hasty lab:
Evolved microbial diversity enables combinatoric biosensing in complex environments
doi.org/10.1101/2025...
Evolved microbial diversity enables combinatoric biosensing in complex environments
doi.org/10.1101/2025...
"In other words, traditional probiotics don’t really work, but you should give these new ones a try and keep an eye out for more evidence-based probiotics in the future!"
#synbio #probiotics
#synbio #probiotics
There’s a New Generation of Probiotics Coming to a Store Near You - SynBioBeta
www.synbiobeta.com
March 26, 2025 at 5:26 AM
"In other words, traditional probiotics don’t really work, but you should give these new ones a try and keep an eye out for more evidence-based probiotics in the future!"
#synbio #probiotics
#synbio #probiotics
Reposted by Sourik Dey
Researchers at @mitchemistry.bsky.social have developed a new system for delivering peptide-based drugs, like GLP-1, by “painting” them on antibodies to improve and prolong their therapeutic effects. They report their results today at #ACSSpring2025: buff.ly/f6oHqxb
buff.ly
March 23, 2025 at 3:00 PM
Researchers at @mitchemistry.bsky.social have developed a new system for delivering peptide-based drugs, like GLP-1, by “painting” them on antibodies to improve and prolong their therapeutic effects. They report their results today at #ACSSpring2025: buff.ly/f6oHqxb
Reposted by Sourik Dey
Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient!
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
March 21, 2025 at 7:06 AM
Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient!
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
Reposted by Sourik Dey
When you grow yeast on yeast extract medium
March 21, 2025 at 2:30 PM
When you grow yeast on yeast extract medium
Reposted by Sourik Dey
Synthetic Biology runs on plasmids and we've got some for engineering lactobacilli that are in high demand!
So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan...
Thanks @sourikdey.bsky.social & @marcblanch.bsky.social
So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan...
Thanks @sourikdey.bsky.social & @marcblanch.bsky.social
March 18, 2025 at 7:43 AM
Synthetic Biology runs on plasmids and we've got some for engineering lactobacilli that are in high demand!
So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan...
Thanks @sourikdey.bsky.social & @marcblanch.bsky.social
So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan...
Thanks @sourikdey.bsky.social & @marcblanch.bsky.social
Reposted by Sourik Dey
Online now: Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models
Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models
Gelatin methacryloyl (GelMA) was harnessed to create nanotraps via molecular imprinting that were specifically designed to scavenge interleukin-6 (IL-6) in inflammation models. This innovative approach leverages safe and biocompatible protein-based…
dlvr.it
March 8, 2025 at 4:15 PM
Online now: Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models
Reposted by Sourik Dey
Good branding
March 9, 2025 at 12:11 AM
Good branding
Reposted by Sourik Dey
It's hard to express how lucky I feel to have a team that self-organizes a vibrant lunch together on a Saturday and are happy to have their boss there 🤓
We even got to celebrate our wonderful women in science on Women's Day! 👩🔬
#womensday
We even got to celebrate our wonderful women in science on Women's Day! 👩🔬
#womensday
March 8, 2025 at 6:06 PM
It's hard to express how lucky I feel to have a team that self-organizes a vibrant lunch together on a Saturday and are happy to have their boss there 🤓
We even got to celebrate our wonderful women in science on Women's Day! 👩🔬
#womensday
We even got to celebrate our wonderful women in science on Women's Day! 👩🔬
#womensday
Reposted by Sourik Dey
Genetically altered 'woolly mice' express several mammoth-like traits, including the animal's iconic coat. The cuteness, meanwhile, is a complete coincidence. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
March 4, 2025 at 3:21 PM
Genetically altered 'woolly mice' express several mammoth-like traits, including the animal's iconic coat. The cuteness, meanwhile, is a complete coincidence. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
Reposted by Sourik Dey
Exploring the principles behind antibiotics with limited resistance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
www.nature.com
February 27, 2025 at 9:54 PM
Exploring the principles behind antibiotics with limited resistance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sourik Dey
The first night ended in a burial ritual on the beach, symbolically burying our presumptions and assumptions that we brought with us from all over the world, to start the first day of work with an open mind.
February 26, 2025 at 7:23 PM
The first night ended in a burial ritual on the beach, symbolically burying our presumptions and assumptions that we brought with us from all over the world, to start the first day of work with an open mind.
These kind of research are one of the reasons why people lose their trust in science! #cancer #ridiculous
forbetterscience.com/2025/02/26/t...
forbetterscience.com/2025/02/26/t...
The Men Who Stare At Mice
“Do Cohen’s colleagues and superiors know or care that he hosts wizards in his lab? Or perhaps this is simply common place, wizards roam throughout MD Anderson free range, blasting the …
forbetterscience.com
February 26, 2025 at 12:12 PM
These kind of research are one of the reasons why people lose their trust in science! #cancer #ridiculous
forbetterscience.com/2025/02/26/t...
forbetterscience.com/2025/02/26/t...
Reposted by Sourik Dey
A former Stanford employee was convicted of altering data used in a breast cancer study after she was fired, according to the United States Department of Justice.
www.kron4.com/news/bay-are...
www.kron4.com/news/bay-are...
www.kron4.com
February 26, 2025 at 7:30 AM
A former Stanford employee was convicted of altering data used in a breast cancer study after she was fired, according to the United States Department of Justice.
www.kron4.com/news/bay-are...
www.kron4.com/news/bay-are...