Sophie Adler
@sophieadlerwagstyl.bsky.social
paediatric trainee | academic clinical fellow |mum x3 | neuroimaging | epilepsy | children | UCL
Reposted by Sophie Adler
📢 Paper out! Focal Cortical Dysplasia-linked epilepsy is more complex than expected - somatic mTOR-activating mutations affect multiple cell lineages, yet only a fraction become cytomegalic. Dysmorphic neurons show mitochondrial dysfunction. #Epilepsy #BrainMosaicism #Neurodevelopment
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - Nature Neuroscience
In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dys...
www.nature.com
May 15, 2025 at 1:55 PM
📢 Paper out! Focal Cortical Dysplasia-linked epilepsy is more complex than expected - somatic mTOR-activating mutations affect multiple cell lineages, yet only a fraction become cytomegalic. Dysmorphic neurons show mitochondrial dysfunction. #Epilepsy #BrainMosaicism #Neurodevelopment
Reposted by Sophie Adler
Great to see MELD Graph being put to use by the team at Great Ormond Street @greatormondst.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social
April 17, 2025 at 4:32 PM
Great to see MELD Graph being put to use by the team at Great Ormond Street @greatormondst.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social
#AI to find subtle #epilepsy lesions - check out @konradwagstyl.bsky.social explaining MELD Graph in the video! www.yahoo.com/news/ai-dete...
AI can detect minute brain abnormalities to treat epilepsy
STORY: :: King's College London/UCLThis MRI scan of a human brain shows in red an area that could be a potential lesion, and a possible cause of epilepsy.And a new artificial intelligence tool develop...
www.yahoo.com
March 15, 2025 at 2:22 PM
#AI to find subtle #epilepsy lesions - check out @konradwagstyl.bsky.social explaining MELD Graph in the video! www.yahoo.com/news/ai-dete...
Reposted by Sophie Adler
A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving researchers at @uclpophealthsci.bsky.social and @greatormondst.bsky.social www.ucl.ac.uk/news/2025/ma...
Genomics to revolutionise treatment of childhood rare diseases
A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving resea...
www.ucl.ac.uk
March 6, 2025 at 12:55 PM
A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving researchers at @uclpophealthsci.bsky.social and @greatormondst.bsky.social www.ucl.ac.uk/news/2025/ma...
Really exciting to have our new AI tool, MELD Graph, featured on BBC News - Epilepsy AI tool detects brain lesions doctors miss
www.bbc.com/news/article...
www.bbc.com/news/article...
Epilepsy AI tool detects brain lesions doctors miss
One in five epilepsy patients has uncontrolled seizures due to brain abnormalities too subtle for doctors to spot.
www.bbc.com
February 25, 2025 at 10:00 AM
Really exciting to have our new AI tool, MELD Graph, featured on BBC News - Epilepsy AI tool detects brain lesions doctors miss
www.bbc.com/news/article...
www.bbc.com/news/article...
Amazing work by @mathrip.bsky.social and the whole team creating MELD Graph - an AI tool to detect FCDs
Download it and test out this research tool on your patient's MRI scans!
Download it and test out this research tool on your patient's MRI scans!
Very pleased to officially introduce MELD Graph, a novel AI tool for the detection of subtle focal cortical dysplasia (FCD) lesions in epilepsy patients.
Check out our paper published in JAMA Neurology yesterday! 😀https://jamanetwork.com/journals/jamaneurology/fullarticle/2830410
Check out our paper published in JAMA Neurology yesterday! 😀https://jamanetwork.com/journals/jamaneurology/fullarticle/2830410
Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks
This study evaluates the efficacy and interpretability of graph neural networks in automatically detecting focal cortical dysplasia lesions on magnetic resonance imaging scans.
jamanetwork.com
February 25, 2025 at 9:58 AM
Amazing work by @mathrip.bsky.social and the whole team creating MELD Graph - an AI tool to detect FCDs
Download it and test out this research tool on your patient's MRI scans!
Download it and test out this research tool on your patient's MRI scans!
Reposted by Sophie Adler
A team of researchers including Prof Helen Cross & Drs @mathrip.bsky.social & @sophieadlerwagstyl.bsky.social @uclpophealthsci.bsky.social has developed an AI tool that can detect 64% of brain abnormalities associated with epilepsy that were missed by human radiologists www.ucl.ac.uk/news/2025/fe...
AI to diagnose invisible brain abnormalities in children with epilepsy
A team of researchers from UCL and King’s College London has developed an AI-powered tool that can detect 64% of brain abnormalities associated with epilepsy, that were missed by human radiologists.
www.ucl.ac.uk
February 24, 2025 at 5:40 PM
A team of researchers including Prof Helen Cross & Drs @mathrip.bsky.social & @sophieadlerwagstyl.bsky.social @uclpophealthsci.bsky.social has developed an AI tool that can detect 64% of brain abnormalities associated with epilepsy that were missed by human radiologists www.ucl.ac.uk/news/2025/fe...
Invigorating and inspiring start to #epilepsyresearch in 2025 @youngepilepsy research retreat spanning across imaging, diagnostics, management, wellbeing, comobidities and outcomes.
January 17, 2025 at 12:25 PM
Invigorating and inspiring start to #epilepsyresearch in 2025 @youngepilepsy research retreat spanning across imaging, diagnostics, management, wellbeing, comobidities and outcomes.
Reposted by Sophie Adler
Reposted by Sophie Adler
Most babies who got very sick from RSV the last few winters were previously healthy. jamanetwork.com/journals/jam...
Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak
This cross-sectional study evaluates the characteristics of infants admitted to US intensive care units for respiratory syncytial virus (RSV) infection during the 2022 seasonal peak.
jamanetwork.com
December 9, 2024 at 12:16 PM
Most babies who got very sick from RSV the last few winters were previously healthy. jamanetwork.com/journals/jam...
Yesterday @konradwagstyl.bsky.social went "under the hood" - explaining the features the #AI model uses and how each added piece of info increases our confidence in where a lesion is #AES2024
December 10, 2024 at 3:33 AM
Yesterday @konradwagstyl.bsky.social went "under the hood" - explaining the features the #AI model uses and how each added piece of info increases our confidence in where a lesion is #AES2024
Interested in joining the MELD Project or trying out the tools for FCD or HS detection? Come chat to us #aes2024 after the presidential symposium or at the posters! @konradwagstyl.bsky.social
December 7, 2024 at 6:52 PM
Interested in joining the MELD Project or trying out the tools for FCD or HS detection? Come chat to us #aes2024 after the presidential symposium or at the posters! @konradwagstyl.bsky.social
Interested in imaging of epilepsy?? Join our session tomorrow on Imaging: past, passing and to come. Excited to be sharing our recent #MELDProjecg work @amepilepsysoc.bsky.social
December 6, 2024 at 8:11 PM
Interested in imaging of epilepsy?? Join our session tomorrow on Imaging: past, passing and to come. Excited to be sharing our recent #MELDProjecg work @amepilepsysoc.bsky.social
Reposted by Sophie Adler
Thrilled to meet up with great friends and colleagues at #AES2024 in LA this week + good excuse to engage more w/ BlueSky! Don’t miss our session on Advanced Neuroimaging for Personalized Epilepsy Surgery—designed for clinicians & researchers, including patient testimony
@amepilepsysoc.bsky.social
@amepilepsysoc.bsky.social
December 2, 2024 at 4:50 PM
Thrilled to meet up with great friends and colleagues at #AES2024 in LA this week + good excuse to engage more w/ BlueSky! Don’t miss our session on Advanced Neuroimaging for Personalized Epilepsy Surgery—designed for clinicians & researchers, including patient testimony
@amepilepsysoc.bsky.social
@amepilepsysoc.bsky.social
📢 JOB AD 📢
Interested in gene expression, neurodevelopment, rare genetic disorders, machine learning .. apply to join our growing team!
Interested in gene expression, neurodevelopment, rare genetic disorders, machine learning .. apply to join our growing team!
🚨📣Job ad 📣🚨
Interested in a post-doc creating machine learning tools for neurodevelopmental disorders? Come work with us at the IMAGINE lab!
www.kcl.ac.uk/jobs/100005-...
imaginelab.github.io
Interested in a post-doc creating machine learning tools for neurodevelopmental disorders? Come work with us at the IMAGINE lab!
www.kcl.ac.uk/jobs/100005-...
imaginelab.github.io
December 5, 2024 at 4:02 PM
📢 JOB AD 📢
Interested in gene expression, neurodevelopment, rare genetic disorders, machine learning .. apply to join our growing team!
Interested in gene expression, neurodevelopment, rare genetic disorders, machine learning .. apply to join our growing team!