Simpson Lab at UW
@simpsonlabuw.bsky.social
Illuminating keratinocyte cell biology in the Dept of Dermatology at Univ of Washington to understand epidermal differentiation/integrity & their compromise in skin disease. PI: Cory Simpson, MD/PhD, dermatologist specializing in rare blistering disorders.
Thanks to the LEO Foundation for a 2nd investment in my lab @uwdermatology.bsky.social @uwmedicine.bsky.social @uwiscrm.bsky.social. This "Serendipity Grant" lets us follow up on unexpected data in #HaileyHailey disease, a #rare #genetic #skin #blistering disorder:
simpsonskinlab.org/news/simpson...
simpsonskinlab.org/news/simpson...
Simpson Lab Awarded $600K Serendipity Grant from LEO Foundation to Extend Studies of Hailey-Hailey Disease | Cory Simpson Laboratory
simpsonskinlab.org
October 12, 2025 at 6:08 PM
Thanks to the LEO Foundation for a 2nd investment in my lab @uwdermatology.bsky.social @uwmedicine.bsky.social @uwiscrm.bsky.social. This "Serendipity Grant" lets us follow up on unexpected data in #HaileyHailey disease, a #rare #genetic #skin #blistering disorder:
simpsonskinlab.org/news/simpson...
simpsonskinlab.org/news/simpson...
When joining a small dept @uwdermatology.bsky.social I knew finding a peer grp would be crucial—I’m grateful for a crew of junior PIs @uwiscrm.bsky.social @uwmedicine.bsky.social. At a tough time for #academic #research labs it’s helpful to have supportive colleagues to share good news & struggles 🍻
August 28, 2025 at 1:16 AM
When joining a small dept @uwdermatology.bsky.social I knew finding a peer grp would be crucial—I’m grateful for a crew of junior PIs @uwiscrm.bsky.social @uwmedicine.bsky.social. At a tough time for #academic #research labs it’s helpful to have supportive colleagues to share good news & struggles 🍻
Michael Martin gave a great talk on his project @uwdermatology.bsky.social testing new Rx for #HaileyHailey disease, a #genetic #skin #blistering disorder. Thx @drsakiyama.bsky.social & @amyserafino.bsky.social for fostering undergrad collab @uwmedicine.bsky.social & @gonzagauniversity.bsky.social!
August 21, 2025 at 11:47 PM
Michael Martin gave a great talk on his project @uwdermatology.bsky.social testing new Rx for #HaileyHailey disease, a #genetic #skin #blistering disorder. Thx @drsakiyama.bsky.social & @amyserafino.bsky.social for fostering undergrad collab @uwmedicine.bsky.social & @gonzagauniversity.bsky.social!
Great talk from summer student Porter from @uwsom-wwami.bsky.social. In my lab @uwdermatology.bsky.social he is studying #epidermolysis #bullosa simplex, a #genetic #skin #blistering disease most severe in newborns/children. We’ve known the #EBS cause for >30 yrs, yet still have no approved therapy.
August 21, 2025 at 2:49 AM
Great talk from summer student Porter from @uwsom-wwami.bsky.social. In my lab @uwdermatology.bsky.social he is studying #epidermolysis #bullosa simplex, a #genetic #skin #blistering disease most severe in newborns/children. We’ve known the #EBS cause for >30 yrs, yet still have no approved therapy.
Mixed emotions as we bid farewell to Afua to start her M.D. journey at WSU! So grateful for our 3+yr partnership as my 1st hire, who built a strong foundation for our lab @uwdermatology.bsky.social and will always be queen 👑 of western blots 🤩 Looking forward to seeing this future physician thrive!
August 10, 2025 at 4:10 AM
Mixed emotions as we bid farewell to Afua to start her M.D. journey at WSU! So grateful for our 3+yr partnership as my 1st hire, who built a strong foundation for our lab @uwdermatology.bsky.social and will always be queen 👑 of western blots 🤩 Looking forward to seeing this future physician thrive!
My lab @uwdermatology.bsky.social aims to find new therapies for #EpidermolysisBullosa Simplex (EBS) a #genetic #skin #disease causing life-threatening #blistering starting at birth. Every patient deserves a chance for a cure no matter how rare their disease: www.dermatologytimes.com/view/human-s...
Human Skin Models Advance EBS Research
Traditional mouse models for EBS are limited, prompting Simpson's lab to create more accurate human-based tissue models.
www.dermatologytimes.com
August 4, 2025 at 6:32 AM
My lab @uwdermatology.bsky.social aims to find new therapies for #EpidermolysisBullosa Simplex (EBS) a #genetic #skin #disease causing life-threatening #blistering starting at birth. Every patient deserves a chance for a cure no matter how rare their disease: www.dermatologytimes.com/view/human-s...
Awesome story about #lamellar bodies, unique #keratinocyte #organelles secreted as the “mortar” of the #epidermis that prevents our #skin from drying out. We were ecstatic to play a small part. Especially cool since the organelle was discovered decades ago by Dr Odland at @uwdermatology.bsky.social.
So thrilled to finally share our story describing Flower as a regulator of lamellar body (LB) trafficking in the epidermis!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier - Nature Communications
The barrier function of skin epidermis requires polarized secretion of lamellar bodies towards the body surface. Here, Rudd et al. identify Flower (FWE) as a novel regulator of lamellar body trafficki...
www.nature.com
July 28, 2025 at 7:22 AM
Awesome story about #lamellar bodies, unique #keratinocyte #organelles secreted as the “mortar” of the #epidermis that prevents our #skin from drying out. We were ecstatic to play a small part. Especially cool since the organelle was discovered decades ago by Dr Odland at @uwdermatology.bsky.social.
Karina & I were lucky to collaborate on this study by Creighton MD/PhD student & #derm applicant Justin Rudd of the Hansen Lab. Gorgeous #microscopy +omics illuminated the biology of #Odland (lamellar) bodies that were discovered @uwdermatology.bsky.social!
www.nature.com/articles/s41467-025-62105-1
www.nature.com/articles/s41467-025-62105-1
Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier - Nature Communications
The barrier function of skin epidermis requires polarized secretion of lamellar bodies towards the body surface. Here, Rudd et al. identify Flower (FWE) as a novel regulator of lamellar body trafficki...
www.nature.com
July 26, 2025 at 6:37 PM
Karina & I were lucky to collaborate on this study by Creighton MD/PhD student & #derm applicant Justin Rudd of the Hansen Lab. Gorgeous #microscopy +omics illuminated the biology of #Odland (lamellar) bodies that were discovered @uwdermatology.bsky.social!
www.nature.com/articles/s41467-025-62105-1
www.nature.com/articles/s41467-025-62105-1
1st time at Society for #Pediatric #Dermatology #SPD2025 mtg to share work from my lab @uwdermatology.bsky.social. Our new project models #EpidermolysisBullosa simplex which causes painful blistering but has no approved Rx despite approval for other forms. We are working to change that for patients.
July 24, 2025 at 6:31 PM
1st time at Society for #Pediatric #Dermatology #SPD2025 mtg to share work from my lab @uwdermatology.bsky.social. Our new project models #EpidermolysisBullosa simplex which causes painful blistering but has no approved Rx despite approval for other forms. We are working to change that for patients.
Sent a plea to @murray.senate.gov to save #NIH & #StandUpforScience. We have so much to lose from a proposed 40% cut. Labs like ours working on rare dz w/o any approved therapy will be shuttered. NIH-funded research is what allows medicine to progress, clinical trials to advance and cures to emerge.
July 17, 2025 at 3:47 AM
Sent a plea to @murray.senate.gov to save #NIH & #StandUpforScience. We have so much to lose from a proposed 40% cut. Labs like ours working on rare dz w/o any approved therapy will be shuttered. NIH-funded research is what allows medicine to progress, clinical trials to advance and cures to emerge.
Reposted by Simpson Lab at UW
Future of NIH in the hands of five senators.
Write to them if you are in
PA -McCormick
WV - Moore Capito
ME - Collins
AL - Britt
LA - Cassidy
Write to them if you are in
PA -McCormick
WV - Moore Capito
ME - Collins
AL - Britt
LA - Cassidy
July 16, 2025 at 9:53 PM
Future of NIH in the hands of five senators.
Write to them if you are in
PA -McCormick
WV - Moore Capito
ME - Collins
AL - Britt
LA - Cassidy
Write to them if you are in
PA -McCormick
WV - Moore Capito
ME - Collins
AL - Britt
LA - Cassidy
Wonderful start to summer @uwdermatology.bsky.social. Excited to welcome @uwsom-wwami.bsky.social med student Porter & @gonzagauniversity.bsky.social undergrad Michael for summer projects on rare #skin #blistering diseases #HaileyHailey & #EpidermolysisBullosa. Thanks to Arti for a delicious lunch!
July 12, 2025 at 3:41 AM
Wonderful start to summer @uwdermatology.bsky.social. Excited to welcome @uwsom-wwami.bsky.social med student Porter & @gonzagauniversity.bsky.social undergrad Michael for summer projects on rare #skin #blistering diseases #HaileyHailey & #EpidermolysisBullosa. Thanks to Arti for a delicious lunch!
Cuts to #NIH will not only limit federal funds for clinical trials, but will also slow or halt the basic research done in labs like ours that aim to discover the next generation of therapies. This is especially devastating for so many rare diseases, most of which still lack even 1 FDA-approved drug.
Trump's NIH Director is asking for an $18 BILLION cut to NIH.
He refused to say how many fewer clinical trials would be funded as a result. That’s because he knows these cuts mean fewer clinical trials & fewer cures.
Trump's budget is going NOWHERE as far as I'm concerned.
He refused to say how many fewer clinical trials would be funded as a result. That’s because he knows these cuts mean fewer clinical trials & fewer cures.
Trump's budget is going NOWHERE as far as I'm concerned.
June 11, 2025 at 4:02 AM
Cuts to #NIH will not only limit federal funds for clinical trials, but will also slow or halt the basic research done in labs like ours that aim to discover the next generation of therapies. This is especially devastating for so many rare diseases, most of which still lack even 1 FDA-approved drug.
Congrats to Karina PhD student @uwdermatology.bsky.social who passed her general exam to be a doctoral candidate! 🥳🍾🎉 Her thesis will leverage a novel model of epidermolysis bullosa simplex to understand the biology of this orphan genetic skin blistering disorder that has no FDA-approved therapy🧬🔬🧫👩🔬
June 3, 2025 at 10:45 PM
Congrats to Karina PhD student @uwdermatology.bsky.social who passed her general exam to be a doctoral candidate! 🥳🍾🎉 Her thesis will leverage a novel model of epidermolysis bullosa simplex to understand the biology of this orphan genetic skin blistering disorder that has no FDA-approved therapy🧬🔬🧫👩🔬
Can’t wait for #SIDChicago2026 in the Windy City, where we plan to unite #epidermal #differentiation #disorder researchers from PC Project, Foundation for Ichthyosis & Related Skin Types, and our #Darier & #HaileyHailey Disease Consortium for a synergistic pre-mtg symposium on these rare diseases.
May 11, 2025 at 3:30 PM
Can’t wait for #SIDChicago2026 in the Windy City, where we plan to unite #epidermal #differentiation #disorder researchers from PC Project, Foundation for Ichthyosis & Related Skin Types, and our #Darier & #HaileyHailey Disease Consortium for a synergistic pre-mtg symposium on these rare diseases.
Finally, on Day 4 of #SIDSanDiego2025 we bid farewell to colleagues, alums & mentors. What an energizing @siderm.bsky.social mtg! Proud of my team & their contagious enthusiasm. We met many new collaborators in academia/industry. This mtg gave me back some optimism in an uncertain time for science.
May 11, 2025 at 3:26 PM
Finally, on Day 4 of #SIDSanDiego2025 we bid farewell to colleagues, alums & mentors. What an energizing @siderm.bsky.social mtg! Proud of my team & their contagious enthusiasm. We met many new collaborators in academia/industry. This mtg gave me back some optimism in an uncertain time for science.
Day 3 of #SIDSanDiego2025 included an amazing talk by PhD student Karina from @uwdermatology.bsky.social featuring our new model of #EpidermolysisBullosa Simplex. More catching up w/wonderful friends & I was truly honored to be voted onto the @siderm.bsky.social Board of Directors for a 5-year term.
May 11, 2025 at 3:19 PM
Day 3 of #SIDSanDiego2025 included an amazing talk by PhD student Karina from @uwdermatology.bsky.social featuring our new model of #EpidermolysisBullosa Simplex. More catching up w/wonderful friends & I was truly honored to be voted onto the @siderm.bsky.social Board of Directors for a 5-year term.
Day 2 of #SIDSanDiego2025 did not disappoint! More outstanding talks, a lively poster session, and an awesome Society for Investigative Dermatology social event on the USS Midway 🛳️ 🇺🇸 @siderm.bsky.social
May 11, 2025 at 3:15 PM
Day 2 of #SIDSanDiego2025 did not disappoint! More outstanding talks, a lively poster session, and an awesome Society for Investigative Dermatology social event on the USS Midway 🛳️ 🇺🇸 @siderm.bsky.social
Amazing Day 1 of #SID2025 in San Diego! 😎 So much fun meeting up w/lab alums & collaborators @siderm.bsky.social
Awesome science🔬🧫🧬at #Pachyonychia Symposium followed by an outstanding plenary talk on Hailey-Hailey disease by PhD student Jessica 🤩 @uwdermatology.bsky.social @uwmedicine.bsky.social
Awesome science🔬🧫🧬at #Pachyonychia Symposium followed by an outstanding plenary talk on Hailey-Hailey disease by PhD student Jessica 🤩 @uwdermatology.bsky.social @uwmedicine.bsky.social
May 8, 2025 at 12:20 PM
Amazing Day 1 of #SID2025 in San Diego! 😎 So much fun meeting up w/lab alums & collaborators @siderm.bsky.social
Awesome science🔬🧫🧬at #Pachyonychia Symposium followed by an outstanding plenary talk on Hailey-Hailey disease by PhD student Jessica 🤩 @uwdermatology.bsky.social @uwmedicine.bsky.social
Awesome science🔬🧫🧬at #Pachyonychia Symposium followed by an outstanding plenary talk on Hailey-Hailey disease by PhD student Jessica 🤩 @uwdermatology.bsky.social @uwmedicine.bsky.social
Congrats to Karina for taking home the 1st place poster prize 🏆 at the @uwiscrm.bsky.social Symposium. And kudos to Jessica, who gave an awesome trainee lightning⚡️talk. Proud of both our PhD students for representing the Simpson Lab @uwdermatology.bsky.social @uwmedicine.bsky.social.
April 30, 2025 at 6:28 AM
Congrats to Karina for taking home the 1st place poster prize 🏆 at the @uwiscrm.bsky.social Symposium. And kudos to Jessica, who gave an awesome trainee lightning⚡️talk. Proud of both our PhD students for representing the Simpson Lab @uwdermatology.bsky.social @uwmedicine.bsky.social.
Reposted by Simpson Lab at UW
This is a great 60 Minutes piece on the impact of NIH cuts on patients including those with Alzheimer’s. Great job by Kristin Weinstein from University of Washington highlighting the impacts on students (9:00). @uwmedicine.bsky.social www.cbsnews.com/news/scienti...
Scientists fear Trump administration cuts to NIH could impact the health of Americans for generations
Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans' health.
www.cbsnews.com
April 28, 2025 at 2:45 AM
This is a great 60 Minutes piece on the impact of NIH cuts on patients including those with Alzheimer’s. Great job by Kristin Weinstein from University of Washington highlighting the impacts on students (9:00). @uwmedicine.bsky.social www.cbsnews.com/news/scienti...
Incredible work from @aaandmoore.bsky.social! 🤩
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 22, 2025 at 1:34 AM
Incredible work from @aaandmoore.bsky.social! 🤩
Proud of Jess & Karina who won travel awards from Uplifting Athletes & UC Irvine Skin Bio Resource Ctr to present at the SID @siderm.bsky.social & PC Project mtg on their use of 3D models of #rare #genetic #skin #blistering disorders ( #HaileyHailey & #EpidermolysisBullosa) to find new therapies🤩🔬👩🔬🧫
✈️ Thrilled to share that two @simpsonlabuw.bsky.social PhD students have received travel awards to share their research in #skinbiology!
Jessica Ayers won $1000 from UC Irvine Skin Biology Resource Center, tinyurl.com/4xm98ysz
Karina Schmidt won $1400 from Uplifting Athletes, tinyurl.com/534xb3jj
Jessica Ayers won $1000 from UC Irvine Skin Biology Resource Center, tinyurl.com/4xm98ysz
Karina Schmidt won $1400 from Uplifting Athletes, tinyurl.com/534xb3jj
April 16, 2025 at 11:18 PM
Proud of Jess & Karina who won travel awards from Uplifting Athletes & UC Irvine Skin Bio Resource Ctr to present at the SID @siderm.bsky.social & PC Project mtg on their use of 3D models of #rare #genetic #skin #blistering disorders ( #HaileyHailey & #EpidermolysisBullosa) to find new therapies🤩🔬👩🔬🧫
Reposted by Simpson Lab at UW
Dr. Paul Nghiem, UW Derm Chair & Director @mc3-institute.bsky.social, joined leading US researchers in sounding the alarm over recent cuts & delays in NIH-funded research. The future of life-saving discoveries is on the line. @barrons.com @uwmnewsroom.bsky.social
www.barrons.com/articles/nih...
www.barrons.com/articles/nih...
NIH Funding Is Drying Up. Drug Discovery Could Go With It.
Research funded by NIH was behind every single FDA drug approval from 2010 through 2016.
www.barrons.com
April 7, 2025 at 10:11 PM
Dr. Paul Nghiem, UW Derm Chair & Director @mc3-institute.bsky.social, joined leading US researchers in sounding the alarm over recent cuts & delays in NIH-funded research. The future of life-saving discoveries is on the line. @barrons.com @uwmnewsroom.bsky.social
www.barrons.com/articles/nih...
www.barrons.com/articles/nih...
Enjoyed meeting a great new crowd of scientists at the Amer Assoc for Anatomy @anatomyorg.bsky.social in Portland! Thank you to @anatomyorg.bsky.social for the invitation to share our work from @uwdermatology.bsky.social on mechanisms of #skin #blistering disease & potential new molecular therapies.
March 30, 2025 at 11:21 PM
Enjoyed meeting a great new crowd of scientists at the Amer Assoc for Anatomy @anatomyorg.bsky.social in Portland! Thank you to @anatomyorg.bsky.social for the invitation to share our work from @uwdermatology.bsky.social on mechanisms of #skin #blistering disease & potential new molecular therapies.