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sarahmitchellphd.bsky.social
Dr Sarah Mitchell
@sarahmitchellphd.bsky.social
350 followers 460 following 10 posts

Staff Scientist @ Ludwig Princeton Branch

Videos
Engineering 40%
Political science 17%
Posts Replies Media Videos

Reposted by Sarah Mitchell

natrevcancer.nature.com
Nature Reviews Cancer @natrevcancer.nature.com · 27d
In our current Focus issue, #AgeingandCancer, Marco Demaria outlines how understanding the underlying molecular mechanisms of cancer treatment induced premature ageing-related conditions is crucial for developing integrated strategies to improve survivor health.
Cancer treatments accelerate ageing - Nature Reviews Cancer
While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.
bit.ly

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Aug 3
“One man’s trash is another man’s treasure” 😬

Reposted by Sarah Mitchell

ryanlab.bsky.social
RyanLab_TCD @ryanlab.bsky.social · Jul 25
The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com

Reposted by Sarah Mitchell

martinbjensen.bsky.social
Martin Borch Jensen @martinbjensen.bsky.social · Feb 13
US Biotech is #1.
And depends critically on academic research both for trained PhDs to wrestle cures from Nature and for curiosity-driven eurekas (eg CRISPR or statins).

Private industry will not be able to substitute for an enfeebled NIH.

We will have fewer cures and we will lose our primacy.

Reposted by Sarah Mitchell

meredithwadman.bsky.social
Meredith Wadman @meredithwadman.bsky.social · Feb 27
Important and under-covered attack on the guts of NIH's intramural program from @science.org NIH ban on renewing senior scientists adds to assaults on its in-house research | Science | AAAS www.science.org/content/arti...
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org

Reposted by Sarah Mitchell

animalsocaging.bsky.social
Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · May 23
New Research Network publication alert!

@sheehanmj.bsky.social and @matthewzipple.bsky.social, both recipients of Network Pilot & Feasibility awards, have published a paper in Aging Cell on ecological realism and epigenetic aging in mice. Congratulations, Mike and Matthew! doi.org/10.1111/acel...
Ecological Realism Accelerates Epigenetic Aging in Mice
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory-reared and...
doi.org

Reposted by Jo Handelsman, Sarah Mitchell

sethjudson.bsky.social
Seth Judson @sethjudson.bsky.social · Feb 22
A whole generation of early career scientists and physician-scientists, including colleagues and myself, are particularly vulnerable to these funding freezes and cuts, with jobs and careers depending on federal grants.

#IDsky
#Medsky
#Episky

www.science.org/content/arti...
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
www.science.org

Reposted by Sarah Mitchell

mattyousefzadeh.bsky.social
Matt Yousefzadeh @mattyousefzadeh.bsky.social · Jul 6
www.biorxiv.org/content/10.1...
AAV gene therapy for Cockayne syndrome
Cockayne Syndrome (CS) is an autosomal recessive, progressive developmental and neurodegenerative disease. Approximately 30% of cases are caused by mutations in the ERCC8/CSA gene. Patients with CS present with cutaneous photosensitivity, growth failure, shorter life span and a progressive degeneration of the central nervous system. Loss of function mutations in CSA result in deficiencies in transcription-coupled nucleotide excision repair, regulation of RNA Pol II mediated transcription repair of oxidative DNA damage, and mitochondrial metabolism. Currently there are no available therapies for these patients. AAV gene therapy offers an opportunity to address this unmet need. We designed a new AAV vector encoding human CSA under a CBA promoter. We tested the therapeutic efficacy of this AAV9-CSA vector by neonatal ICV injection in the Csa-/-;Xpa-/- mouse model. Treatment with AAV9-CSA resulted in a significant increase in lifespan, and broad distribution of human CSA in the brain and heart. Despite clear therapeutic benefit, we also observed neuroradiological abnormalities, neuropathologic alterations including hypo-myelination, astrocytosis, microgliosis, and likely life limiting transcriptomic alterations in liver at endpoint. Nonetheless, the success of these experiments paves the way for the first in human clinical translation of a gene therapy for CS patients. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · May 24
Super cool!

Reposted by Sarah Mitchell

cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · May 19
Now online! Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Diet can impact anticancer drug activity. A classic example in rodents is a ketogenic diet enhancing PI3K inhibitor activity. Here, we show that phytochemicals and their microbiome derivatives, rather than macronutrient composition, underlie this phenomenon.
dlvr.it

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · May 10
Camilla is a horse face.

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Mar 20
Wrong Sarah Mitchell!

Reposted by Cary P. Gross, Sarah Mitchell, Susan Hyde , and 8 more

agawande.bsky.social
Atul Gawande @agawande.bsky.social · Mar 13
Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world.

Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...
www.thelancet.com

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Mar 6
Oooh that Elon felon one is good!

Reposted by Sarah Mitchell

c-handschin.bsky.social
Christoph Handschin @c-handschin.bsky.social · Mar 3
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:

doi.org/10.1038/s415...

3/3
Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
doi.org

Reposted by Sarah Mitchell

standupforscience.bsky.social
Stand Up for Science! @standupforscience.bsky.social · Mar 1
"When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about sickle cell disease being cured because of CRISPR gene editing, that was built on years of research supported by NIH"

apnews.com/article/nih-...
Renowned geneticist Francis Collins retires from NIH, urging 'respect' for embattled workers
Dr. Francis Collins, a renowned geneticist, and former longtime director of the National Institutes of Health, is retiring from the government agency and urging “respect” for its embattled workers.
apnews.com

Reposted by Flora D. Salim, Sarah Mitchell, Michael H. Fox , and 4 more

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · Mar 1
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Feb 27
Shocking.
meredithwadman.bsky.social Meredith Wadman @meredithwadman.bsky.social · Feb 27
Important and under-covered attack on the guts of NIH's intramural program from @science.org NIH ban on renewing senior scientists adds to assaults on its in-house research | Science | AAAS www.science.org/content/arti...
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org

Reposted by Sarah Mitchell

carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 26
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com

Reposted by Sarah Mitchell

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Feb 21
Great to see AFAR! We need more of this! @afar.org

Reposted by Sarah Mitchell

kyledcheney.bsky.social
Kyle Cheney @kyledcheney.bsky.social · Feb 18
NEWSY: The White House confirms tonight that Elon Musk is NOT the administrator of DOGE and is not even technically part of it.

He's a "senior adviser to the president" like Anita Dunn, they say. storage.courtlistener.com/recap/gov.us...

Reposted by Sarah Mitchell

warren.senate.gov
Elizabeth Warren @warren.senate.gov · Feb 14
Donald Trump and Elon Musk are trying to cut funding for cancer and rare disease research.

A federal judge temporarily blocked the cuts in some states, but this fight is not over.

We can’t let them play politics with our health.

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Feb 13
This!!!!
martinbjensen.bsky.social Martin Borch Jensen @martinbjensen.bsky.social · Feb 13
US Biotech is #1.
And depends critically on academic research both for trained PhDs to wrestle cures from Nature and for curiosity-driven eurekas (eg CRISPR or statins).

Private industry will not be able to substitute for an enfeebled NIH.

We will have fewer cures and we will lose our primacy.

Reposted by Sarah Mitchell, Alison M. Buttenheim, Wayne Martino

repcasar.bsky.social
Congressman Greg Casar @repcasar.bsky.social · Feb 12
How much Elon Musk makes from the government a day: $8 million.

How much a senior on Social Security gets a day: $65

Guess which budget Musk and Trump want to cut?

Reposted by Robert West, Helen Tager‐Flusberg, Catherine Kyobutungi , and 22 more

standupforscience.bsky.social
Stand Up for Science! @standupforscience.bsky.social · Feb 12
Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

Reposted by Sarah Mitchell

blekhman.bsky.social
Ran Blekhman @blekhman.bsky.social · Feb 8
Government isn't a business. The goal isn't to save money. Success isn't measured by budget surplus.

The goal is to spend money, investing in society. Every dollar spent on education, healthcare, and science is an investment in our collective wellbeing.

sarahmitchellphd.bsky.social
Dr Sarah Mitchell @sarahmitchellphd.bsky.social · Feb 6
Ugh. I hope they don’t pull funding from funded K99 MOSIAC peeps. It would be terrible if they suddenly couldn’t get their R00 phase money.

Reposted by Sarah Mitchell

mblscience.bsky.social
Marine Biological Laboratory @mblscience.bsky.social · Feb 5
Exciting news! MBL has received a $2.6M gift from an anonymous donor! This generous support fuels our mission of discovery, education, and innovation. Private philanthropy drives groundbreaking research and shapes the future of science. 🌎🔬 #ScienceStartsHere #Philanthropy
A drone picture of the Lillie Building at the Marine Biological Laboratory

Reposted by Sarah Mitchell, Alan Hunt, Jarome R. Ali

jcyaroch.bsky.social
Joseph Yaroch @jcyaroch.bsky.social · Feb 2
Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky
This is the front page of a fraudulent research article that purported to show a link between vaccines and autism. The word "RETRACTED" is written across it in large red letters. Wikipedia: On 28th February 1998, a fraudulent research paper by physician Andrew Wakefield and twelve coauthors, titled "Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental Disorder in Children", was published in the British medical journal The Lancet.[1] The paper falsely claimed causative links between the measles, mumps, and rubella (MMR) vaccine and colitis and between colitis and autism. The fraud involved data selection, data manipulation, and two undisclosed conflicts of interest.