Ryan Sayegh
@rsayegh.bsky.social
PhD Candidate at CU Boulder - Aaron Whiteley Lab :: former barber lab member :: views my own :: BLM. ACAB. he/they
Reposted by Ryan Sayegh
I am delighted to share that my work in the @aaronwhiteley.bsky.social lab is now on bioRxiv! We used a large-scale genetic screen to begin defining the vast landscape of phage proteins that trigger immune signaling in bacteria.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Identifying phage proteins that activate the bacterial innate immune system
Bacteria have evolved sophisticated antiphage systems that halt phage replication upon detecting specific phage triggers. Identifying phage triggers is crucial to our understanding of immune signaling...
www.biorxiv.org
July 11, 2025 at 4:15 PM
I am delighted to share that my work in the @aaronwhiteley.bsky.social lab is now on bioRxiv! We used a large-scale genetic screen to begin defining the vast landscape of phage proteins that trigger immune signaling in bacteria.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ryan Sayegh
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Functional amyloid proteins confer defence against predatory bacteria
Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...
rdcu.be
July 2, 2025 at 8:10 PM
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
I am delighted to announce that this past spring, I graduated from the University of Colorado Boulder PhD program. My dissertation work was titled "Defense against predatory bacteria" (1/3)
July 2, 2025 at 12:17 AM
I am delighted to announce that this past spring, I graduated from the University of Colorado Boulder PhD program. My dissertation work was titled "Defense against predatory bacteria" (1/3)
Reposted by Ryan Sayegh
Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes
Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Bacteria use antiphage systems to combat phages, their ubiquitous competitors, and evolve new defenses through repeated reshuffling of basic functional units into novel reformulations. A common theme ...
www.biorxiv.org
April 8, 2025 at 2:52 AM
Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes
Reposted by Ryan Sayegh
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
Check it out:
Check it out:
A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems. In these pathways, including CBASS a...
www.biorxiv.org
March 31, 2025 at 4:27 PM
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
Check it out:
Check it out:
Reposted by Ryan Sayegh
Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Bacteria use antiphage systems to combat phages, their ubiquitous competitors, and evolve new defenses through repeated reshuffling of basic functional units into novel reformulations. A common theme ...
www.biorxiv.org
March 31, 2025 at 10:00 PM
Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
Reposted by Ryan Sayegh
It’s here! Thrilled to be sharing a review article I wrote with @aaronwhiteley.bsky.social exploring the similarities and conservation of immune systems across life rdcu.be/dzSa3
March 1, 2024 at 8:49 PM
It’s here! Thrilled to be sharing a review article I wrote with @aaronwhiteley.bsky.social exploring the similarities and conservation of immune systems across life rdcu.be/dzSa3
Reposted by Ryan Sayegh
Our review comparing bacterial and eukaryotic immune systems is out now. Check out Hannah’s thread for the highlights!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2024 at 9:37 PM
Our review comparing bacterial and eukaryotic immune systems is out now. Check out Hannah’s thread for the highlights!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hi everyone! A quick intro about me in this new virtual space! My name is Ryan Sayegh (pronounced sigh-egg). I use he/they pronouns, and I'm a third-year Ph.D. candidate in the @aaronwhiteley.bsky.social lab interested in host-pathogen interactions in microbes. @ryansayegh98 on the other blue app.
March 4, 2024 at 11:06 PM
Hi everyone! A quick intro about me in this new virtual space! My name is Ryan Sayegh (pronounced sigh-egg). I use he/they pronouns, and I'm a third-year Ph.D. candidate in the @aaronwhiteley.bsky.social lab interested in host-pathogen interactions in microbes. @ryansayegh98 on the other blue app.