Ram Chakrabarty
@rpc3312.bsky.social
PhD candidate in the Chandel Lab at Northwestern University Feinberg School of Medicine. Studying mitochondrial signaling and metabolism.
Pinned
Ram Chakrabarty
@rpc3312.bsky.social
· Dec 18
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I. www.science.org/doi/10.1126/....
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
Reposted by Ram Chakrabarty
Now online! Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport chain components protects against excitotoxic death, as seen in pain-sensing primary afferent neurons (nociceptors).
dlvr.it
August 26, 2025 at 10:39 PM
Now online! Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Reposted by Ram Chakrabarty
Mitochondrial activity tunes nociceptor resilience to excitotoxicity: Cell www.cell.com/cell/fulltex...
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Excitation enables neuronal function; however, overexcitation and calcium overload
can be deadly. This study reveals a cellular resilience program in which reduced expression
of electron transport cha...
www.cell.com
August 27, 2025 at 8:41 AM
Mitochondrial activity tunes nociceptor resilience to excitotoxicity: Cell www.cell.com/cell/fulltex...
Reposted by Ram Chakrabarty
Modulating levels of a mitochondrial metabolite can direct intestinal stem cells to specialise for absorption or secretion
https://go.nature.com/3ZrJ0HI
https://go.nature.com/3ZrJ0HI
Mitochondrial molecule has unexpected role in tissue healing
A key component of the TCA cycle, a series of reactions that occurs in energy-generating organelles called mitochondria, can dictate the fate of intestinal stem cells.
go.nature.com
June 13, 2025 at 9:01 AM
Modulating levels of a mitochondrial metabolite can direct intestinal stem cells to specialise for absorption or secretion
https://go.nature.com/3ZrJ0HI
https://go.nature.com/3ZrJ0HI
Reposted by Ram Chakrabarty
A key component of the TCA cycle, 2-oxoglutarate dehydrogenase, dictates the fate of intestinal stem cells during tissue regeneration @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
June 12, 2025 at 3:28 AM
A key component of the TCA cycle, 2-oxoglutarate dehydrogenase, dictates the fate of intestinal stem cells during tissue regeneration @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Ram Chakrabarty
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Ram Chakrabarty
But…..ok, ok, I’m convinced. Elegant and definitive.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
December 23, 2024 at 2:36 PM
But…..ok, ok, I’m convinced. Elegant and definitive.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I. www.science.org/doi/10.1126/....
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
December 18, 2024 at 7:07 PM
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I. www.science.org/doi/10.1126/....
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
Reposted by Ram Chakrabarty
Big and well-deserved congrats to #NoBlueskyNav on another year in the Clarivate Highly Cited Researchers list in both Molecular Biology and Immunology! clarivate.com/highly-cited...
clarivate.com
November 27, 2024 at 7:56 PM
Big and well-deserved congrats to #NoBlueskyNav on another year in the Clarivate Highly Cited Researchers list in both Molecular Biology and Immunology! clarivate.com/highly-cited...
Reposted by Ram Chakrabarty
Since Nav will never tweet about it
New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD
November 15, 2024 at 8:07 PM
Since Nav will never tweet about it
Reposted by Ram Chakrabarty
Clear and comprehensive new go-to review from #NoTwitterNav (we're gonna need a new hashtag) delineating how mitochondria have distinct and context-specific roles in proliferation and fate determination www.annualreviews.org/content/jour...
www.annualreviews.org
November 14, 2024 at 7:30 PM
Clear and comprehensive new go-to review from #NoTwitterNav (we're gonna need a new hashtag) delineating how mitochondria have distinct and context-specific roles in proliferation and fate determination www.annualreviews.org/content/jour...