Rodrigo Sánchez Martínez
@rodrisanchez95.bsky.social
PhD University of Alicante. Postdoc at @tum.de studying phage-host interactions in the gut. Phages, microbial ecology, cycling, beer and more.
Pinned
Biological context modulates virus-host dynamics and diversification https://www.biorxiv.org/content/10.1101/2025.09.10.675297v1
🦠➡️🧬 Community context matters!
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
Reposted by Rodrigo Sánchez Martínez
Context-Dependent Metabolic Adaptation in Microbial Communities: From Monocultures to Complex Ecological Interactions https://www.biorxiv.org/content/10.1101/2025.10.22.683057v1
October 23, 2025 at 7:06 PM
Context-Dependent Metabolic Adaptation in Microbial Communities: From Monocultures to Complex Ecological Interactions https://www.biorxiv.org/content/10.1101/2025.10.22.683057v1
Reposted by Rodrigo Sánchez Martínez
In a break from recent themes & in honor of World Phage Week (Oct 22-28), some reflections on the world of bacteria and phage, part of a short series explaining the rationale for why we have invested so much time in exploring when microbes get sick too.
joshuasweitz.substack.com/p/happy-worl...
joshuasweitz.substack.com/p/happy-worl...
Happy World Phage Week to All Who Celebrate
Microbes get sick too - infected by bacteriophage or simply ‘phage’. A first post in a series on the hidden world of phage & how they transform human and environmental health.
joshuasweitz.substack.com
October 23, 2025 at 6:30 PM
In a break from recent themes & in honor of World Phage Week (Oct 22-28), some reflections on the world of bacteria and phage, part of a short series explaining the rationale for why we have invested so much time in exploring when microbes get sick too.
joshuasweitz.substack.com/p/happy-worl...
joshuasweitz.substack.com/p/happy-worl...
Reposted by Rodrigo Sánchez Martínez
Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology!
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology
An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...
www.nature.com
October 17, 2025 at 9:54 AM
Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology!
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
Reposted by Rodrigo Sánchez Martínez
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
nature.com
October 15, 2025 at 9:41 PM
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Reposted by Rodrigo Sánchez Martínez
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 6:56 PM
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Rodrigo Sánchez Martínez
It is not only antibiotics but also certain viruses – known as bacteriophages – that can kill off pathogenic bacteria. However, Switzerland lacks the legal framework for the use of these viruses in therapy. What would need to change? Researcher Alexander Harms explains.
ethz.ch/en/news-and-...
ethz.ch/en/news-and-...
“Treatment with bacteriophages can combat antibiotic-resistant infections, but Swiss patients lack access”
It is not only antibiotics but also certain viruses – known as bacteriophages – that can kill off pathogenic bacteria. However, Switzerland lacks the legal framework for the use of these viruses in th...
ethz.ch
September 26, 2025 at 6:42 AM
It is not only antibiotics but also certain viruses – known as bacteriophages – that can kill off pathogenic bacteria. However, Switzerland lacks the legal framework for the use of these viruses in therapy. What would need to change? Researcher Alexander Harms explains.
ethz.ch/en/news-and-...
ethz.ch/en/news-and-...
Reposted by Rodrigo Sánchez Martínez
Excited to highlight our News & Views on the article by Torres et al. from @delafuentelab.bsky.social team 🚀 Archaea could help to discover new antibiotics!
Read it here:
www.nature.com/articles/s41...
Read it here:
www.nature.com/articles/s41...
Deep-mining the archaeal proteome for antibiotics - Nature Microbiology
A deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development of next-generation antibiotics
www.nature.com
September 23, 2025 at 3:43 PM
Excited to highlight our News & Views on the article by Torres et al. from @delafuentelab.bsky.social team 🚀 Archaea could help to discover new antibiotics!
Read it here:
www.nature.com/articles/s41...
Read it here:
www.nature.com/articles/s41...
Reposted by Rodrigo Sánchez Martínez
Excited to annouce the latest research published by our lab, which is led by Dinesh Subedi and is out today in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections - Nature Microbiology
The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.
www.nature.com
September 24, 2025 at 12:20 PM
Excited to annouce the latest research published by our lab, which is led by Dinesh Subedi and is out today in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rodrigo Sánchez Martínez
Deep-mining the archaeal proteome for antibiotics
News & Views by Rafael Laso-Pérez
@gecko1990.bsky.social @delafuentelab.bsky.social
Read it here: rdcu.be/eHNwa
News & Views by Rafael Laso-Pérez
@gecko1990.bsky.social @delafuentelab.bsky.social
Read it here: rdcu.be/eHNwa
Deep-mining the archaeal proteome for antibiotics
Nature Microbiology - A deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development...
rdcu.be
September 23, 2025 at 12:29 PM
Deep-mining the archaeal proteome for antibiotics
News & Views by Rafael Laso-Pérez
@gecko1990.bsky.social @delafuentelab.bsky.social
Read it here: rdcu.be/eHNwa
News & Views by Rafael Laso-Pérez
@gecko1990.bsky.social @delafuentelab.bsky.social
Read it here: rdcu.be/eHNwa
Reposted by Rodrigo Sánchez Martínez
Excellent work done by Borja, Miguel, and Kostas!
Differences in metagenome coverage may confound abundance-based and diversity conclusions and how to deal with them
academic.oup.com/ismecommun/a...
Differences in metagenome coverage may confound abundance-based and diversity conclusions and how to deal with them
academic.oup.com/ismecommun/a...
Differences in metagenome coverage may confound abundance-based and diversity conclusions and how to deal with them
Abstract. The importance of rarefying ecological or amplicon sequencing data to a standardized level of diversity coverage for reliable diversity compariso
academic.oup.com
September 18, 2025 at 10:17 AM
Excellent work done by Borja, Miguel, and Kostas!
Differences in metagenome coverage may confound abundance-based and diversity conclusions and how to deal with them
academic.oup.com/ismecommun/a...
Differences in metagenome coverage may confound abundance-based and diversity conclusions and how to deal with them
academic.oup.com/ismecommun/a...
Reposted by Rodrigo Sánchez Martínez
A new work on how context matters... from the PhD Thesis of Rodrigo the Great
🦠➡️🧬 Community context matters!
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
Biological context modulates virus-host dynamics and diversification https://www.biorxiv.org/content/10.1101/2025.09.10.675297v1
September 11, 2025 at 2:46 PM
A new work on how context matters... from the PhD Thesis of Rodrigo the Great
Reposted by Rodrigo Sánchez Martínez
Happy to share our upcoming paper on pioneer microbial communities, including viruses, establishing after glacier retreat, result of a great collaboration @ua.es @mncn-csic.bsky.social @univgirona.bsky.social @pepa-anton.bsky.social @estherrubioport.bsky.social academic.oup.com/ismecommun/a...
Short-term virus-host interactions and functional dynamics in recently deglaciated Antarctic tundra soils
Abstract. Long-term chronosequence studies have shown that, as glaciers retreat, newly exposed soils become colonized through primary succession. To determ
academic.oup.com
September 11, 2025 at 8:05 AM
Happy to share our upcoming paper on pioneer microbial communities, including viruses, establishing after glacier retreat, result of a great collaboration @ua.es @mncn-csic.bsky.social @univgirona.bsky.social @pepa-anton.bsky.social @estherrubioport.bsky.social academic.oup.com/ismecommun/a...
🦠➡️🧬 Community context matters!
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
Biological context modulates virus-host dynamics and diversification https://www.biorxiv.org/content/10.1101/2025.09.10.675297v1
September 11, 2025 at 5:18 AM
🦠➡️🧬 Community context matters!
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
In the second part of my PhD, we show how microbial complexity drives phage–bacteria ecology & evolution.
Check out the preprint 👇🏼
Reposted by Rodrigo Sánchez Martínez
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
September 10, 2025 at 3:40 PM
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
Reposted by Rodrigo Sánchez Martínez
(1/5)For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery.
Deep learning reveals antibiotics in the archaeal proteome - Nature Microbiology
Use of artificial intelligence to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising ...
www.nature.com
August 12, 2025 at 11:11 AM
(1/5)For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery.
Check out the new paper of my former lab about novel haloviruses infecting Haloquadratum walsbyi, the "square queen archaeon" of hypersaline systems 👑🟪
academic.oup.com/ismej/advanc...
academic.oup.com/ismej/advanc...
Novel viruses of Haloquadratum walsbyi expand the known archaeal virosphere of hypersaline environments
Abstract. Solar salterns represent unique systems with low diversity microbial communities that serve as an excellent model for studying the evolution and
academic.oup.com
August 4, 2025 at 11:14 AM
Check out the new paper of my former lab about novel haloviruses infecting Haloquadratum walsbyi, the "square queen archaeon" of hypersaline systems 👑🟪
academic.oup.com/ismej/advanc...
academic.oup.com/ismej/advanc...
Reposted by Rodrigo Sánchez Martínez
Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health
www.nature.com/articles/s41...
#science #microbiome #health
www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 17, 2025 at 9:06 AM
Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health
www.nature.com/articles/s41...
#science #microbiome #health
www.nature.com/articles/s41...
Reposted by Rodrigo Sánchez Martínez
Kicking off my account with great news🎉: our latest paper on extracellular vesicles from human gut archaea is out in @natcomms.nature.com with
@mkrupovic.bsky.social and @sgribaldo.bsky.social!
Published in parallel with the work of our colleagues from the Moissl-Eichinger Lab @chmoei.bsky.social🧵
@mkrupovic.bsky.social and @sgribaldo.bsky.social!
Published in parallel with the work of our colleagues from the Moissl-Eichinger Lab @chmoei.bsky.social🧵
June 3, 2025 at 3:57 PM
Kicking off my account with great news🎉: our latest paper on extracellular vesicles from human gut archaea is out in @natcomms.nature.com with
@mkrupovic.bsky.social and @sgribaldo.bsky.social!
Published in parallel with the work of our colleagues from the Moissl-Eichinger Lab @chmoei.bsky.social🧵
@mkrupovic.bsky.social and @sgribaldo.bsky.social!
Published in parallel with the work of our colleagues from the Moissl-Eichinger Lab @chmoei.bsky.social🧵
Reposted by Rodrigo Sánchez Martínez
Well done to Cortés Martin et al
#phage #gut #Bacteroides #CrAss
link: www.tandfonline.com/doi/full/10....
@uccresearch.bsky.social
#phage #gut #Bacteroides #CrAss
link: www.tandfonline.com/doi/full/10....
@uccresearch.bsky.social
May 23, 2025 at 1:22 PM
Well done to Cortés Martin et al
#phage #gut #Bacteroides #CrAss
link: www.tandfonline.com/doi/full/10....
@uccresearch.bsky.social
#phage #gut #Bacteroides #CrAss
link: www.tandfonline.com/doi/full/10....
@uccresearch.bsky.social
Looking for a postdoc position in microbial aquatic ecology? Apply!!!
🧪 We are excited to announce a Postdoc researcher position in microbial ecology for our newly funded international project between Czechia, Germany and Poland.
For more info, contact me (villena@alga.cz) and check the link to apply for an exciting scientific journey 🧪
mbu.cas.cz/kariera/voln...
For more info, contact me (villena@alga.cz) and check the link to apply for an exciting scientific journey 🧪
mbu.cas.cz/kariera/voln...
Postdoc Opportunity in Aquatic Microbial Ecology - Mikrobiologický ústav AV ČR, v. v. i.
We are looking for a motivated Postdoctoral Researcher to join our international research team of Anoxygenic Phototrophs at ALGATECH, Třeboň, Czech Academy of
mbu.cas.cz
May 26, 2025 at 1:25 PM
Looking for a postdoc position in microbial aquatic ecology? Apply!!!
Reposted by Rodrigo Sánchez Martínez
Emergent higher-order interactions enable coexistence in phage-bacteria community dynamics https://www.biorxiv.org/content/10.1101/2025.05.15.651590v1
May 16, 2025 at 3:23 PM
Reposted by Rodrigo Sánchez Martínez
It’s Thursday! Episode #91 of #MattersMicrobial is up. Dr. Emily Davenport of Penn State joins the #QualityQuorum to discuss how host genetics impacts the microbiome. Please spread the #GoodMicrobialWord! @microbe.tv @asmicrobiology @univpugetsound
youtu.be/5c7lxC1mHxk?...
youtu.be/5c7lxC1mHxk?...
May 16, 2025 at 1:27 AM
It’s Thursday! Episode #91 of #MattersMicrobial is up. Dr. Emily Davenport of Penn State joins the #QualityQuorum to discuss how host genetics impacts the microbiome. Please spread the #GoodMicrobialWord! @microbe.tv @asmicrobiology @univpugetsound
youtu.be/5c7lxC1mHxk?...
youtu.be/5c7lxC1mHxk?...
Officially published! 🧬🦠
What if more phages didn't mean more death? We show that even strictly lytic phages can stabilize host populations via persistent, episomal infections (often referred to as pseudolysogeny). It's time to move beyond the lysis/lysogeny binary. #phagesky #microsky
What if more phages didn't mean more death? We show that even strictly lytic phages can stabilize host populations via persistent, episomal infections (often referred to as pseudolysogeny). It's time to move beyond the lysis/lysogeny binary. #phagesky #microsky
Thrilled to share the first part of my PhD, published today in The ISME Journal! A wonderful collaboration with Akash Arani (co-first author), @joshuasweitz.bsky.social , and @mkrupovic.bsky.social . Huge thanks to my mentors Fer and Pepa for their constant support. Let’s keep going! #phage
Episomal virus maintenance enables bacterial population recovery from infection and promotes virus-bacterial coexistence
Abstract. Viruses are ubiquitous in aquatic environments with total densities of virus-like particles often exceeding 107/ml in surface marine oligotrophic
academic.oup.com
May 12, 2025 at 11:54 AM
Reposted by Rodrigo Sánchez Martínez
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 8, 2025 at 8:27 PM
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Reposted by Rodrigo Sánchez Martínez
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors”
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons
Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.
www.science.org
May 1, 2025 at 10:04 PM
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors”
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...