Rikeish R Muralitharan MD, PhD
@rikeish.bsky.social
Research Fellow @FZMarques lab, @monashbiol Gut microbiome. Immune system. Diet. SCFAs. Hypertension. he/him
Pinned
Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research
BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites
called short-chain fatty acids, which lower blood pressure and exert cardioprotective
effects. Sh...
www.ahajournals.org
I am super proud and excited to share my latest publication, out now in @ahajournals.bsky.social (www.ahajournals.org/doi/10.1161/...)
Reposted by Rikeish R Muralitharan MD, PhD
Congratulations Dr Lizzie Kleeman, Dr Carol Gubert, @anthonyjhannan.bsky.social & co-authors 👏👏👏
Thank you for the invitation for @rikeish.bsky.social and I to help with the #microbiome analysis requested by reviewers - a pleasure to work with you as always
@natureportfolio.nature.com
Thank you for the invitation for @rikeish.bsky.social and I to help with the #microbiome analysis requested by reviewers - a pleasure to work with you as always
@natureportfolio.nature.com
I am delighted to share our new paper! nature.com/articles/s41...
Lizzie Kleeman & our Florey Institute team, with WEHI, UoM & others, found that paternal COVID-19 (SARS-CoV-2 infection) can alter sperm & offspring phenotypes, including anxiety. This discovery has major (brain) health implications!
Lizzie Kleeman & our Florey Institute team, with WEHI, UoM & others, found that paternal COVID-19 (SARS-CoV-2 infection) can alter sperm & offspring phenotypes, including anxiety. This discovery has major (brain) health implications!
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner - Nature Communications
Whether paternal pre-conceptual SARS-CoV-2 infection impacts sperm RNA content, or effects offspring phenotypes, has not been previously investigated. Here authors report changes in sperm noncoding RNAs in SARS-CoV-2 infected sires and increased anxiety-like behaviors in offspring.
nature.com
October 12, 2025 at 8:24 PM
Congratulations Dr Lizzie Kleeman, Dr Carol Gubert, @anthonyjhannan.bsky.social & co-authors 👏👏👏
Thank you for the invitation for @rikeish.bsky.social and I to help with the #microbiome analysis requested by reviewers - a pleasure to work with you as always
@natureportfolio.nature.com
Thank you for the invitation for @rikeish.bsky.social and I to help with the #microbiome analysis requested by reviewers - a pleasure to work with you as always
@natureportfolio.nature.com
🚀 Big milestone achieved!
GRAINS-BP trial is officially underway as we’ve randomised our first participant.
Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌
For more information and recruitment, please check out www.marqueslab.com/trials
GRAINS-BP trial is officially underway as we’ve randomised our first participant.
Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌
For more information and recruitment, please check out www.marqueslab.com/trials
August 12, 2025 at 2:33 AM
🚀 Big milestone achieved!
GRAINS-BP trial is officially underway as we’ve randomised our first participant.
Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌
For more information and recruitment, please check out www.marqueslab.com/trials
GRAINS-BP trial is officially underway as we’ve randomised our first participant.
Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌
For more information and recruitment, please check out www.marqueslab.com/trials
Reposted by Rikeish R Muralitharan MD, PhD
Our latest paper is out in Cardiovascular Research
We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated
Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social
academic.oup.com/cardiovascre...
We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated
Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social
academic.oup.com/cardiovascre...
Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk
Gut microbial metabolites called short-chain fatty acids (SCFAs) confer protection against cardiovascular disease (CVD) and its primary risk factor, hypert
academic.oup.com
May 25, 2025 at 11:33 PM
Our latest paper is out in Cardiovascular Research
We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated
Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social
academic.oup.com/cardiovascre...
We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated
Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social
academic.oup.com/cardiovascre...
Reposted by Rikeish R Muralitharan MD, PhD
Our review on the gut-heart axis published in Circ Res is now out www.ahajournals.org/doi/10.1161/...
We cover gut #microbiome, 'leaky gut', foods & metabolites, +++
Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏
We cover gut #microbiome, 'leaky gut', foods & metabolites, +++
Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏
American Heart Association Journals
www.ahajournals.org
May 25, 2025 at 11:38 PM
Our review on the gut-heart axis published in Circ Res is now out www.ahajournals.org/doi/10.1161/...
We cover gut #microbiome, 'leaky gut', foods & metabolites, +++
Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏
We cover gut #microbiome, 'leaky gut', foods & metabolites, +++
Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏
🧠🦠Can the gut communicate with the brain to regulate BP?
Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...
Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...
Cross-talk between microbiota–gut–brain axis and blood pressure regulation
Hypertension, or high blood pressure (BP), is a widespread condition affecting one in three adults globally. Despite the availability of treatment options, 50% of hypertensive patients in countries su...
doi.org
May 18, 2025 at 10:17 PM
🧠🦠Can the gut communicate with the brain to regulate BP?
Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...
Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...
🚨 EMCRs in cardiovascular research!
Join our free webinar on the NHMRC Investigator Grant Scheme 🧠
📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…#NHMRCR#CardioResearchc#EMCRC#SACVRNR#VicCVRNRN
Join our free webinar on the NHMRC Investigator Grant Scheme 🧠
📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…#NHMRCR#CardioResearchc#EMCRC#SACVRNR#VicCVRNRN
Note: Since your browser does not support JavaScript, you must press the Continue button once to proceed.
https://monash.zoom.us/webinar/regist…
May 18, 2025 at 10:11 PM
🚨 EMCRs in cardiovascular research!
Join our free webinar on the NHMRC Investigator Grant Scheme 🧠
📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…#NHMRCR#CardioResearchc#EMCRC#SACVRNR#VicCVRNRN
Join our free webinar on the NHMRC Investigator Grant Scheme 🧠
📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…#NHMRCR#CardioResearchc#EMCRC#SACVRNR#VicCVRNRN
Reposted by Rikeish R Muralitharan MD, PhD
Could the connection between the #gutmicrobiome and hypertension pave the way to better management strategies?
New findings in mice provide clues:
New findings in mice provide clues:
Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research
BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain fatty acids activate host signaling responses via the functionally redundant receptors GPR...
www.ahajournals.org
March 26, 2025 at 9:02 AM
Could the connection between the #gutmicrobiome and hypertension pave the way to better management strategies?
New findings in mice provide clues:
New findings in mice provide clues:
Reposted by Rikeish R Muralitharan MD, PhD
How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
March 13, 2025 at 7:54 PM
How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
Reposted by Rikeish R Muralitharan MD, PhD
Congrats @rikeish.bsky.social for your immunofluorescence image making it to the cover 👏👏👏 www.ahajournals.org/journal/res
Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)
Paper and 🧵 👇
www.ahajournals.org/doi/full/10....
Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)
Paper and 🧵 👇
www.ahajournals.org/doi/full/10....
February 13, 2025 at 9:28 PM
Congrats @rikeish.bsky.social for your immunofluorescence image making it to the cover 👏👏👏 www.ahajournals.org/journal/res
Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)
Paper and 🧵 👇
www.ahajournals.org/doi/full/10....
Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)
Paper and 🧵 👇
www.ahajournals.org/doi/full/10....
Super excited to join @ahajournals.bsky.social Hypertension as an #ECR editorial assistant!
February 6, 2025 at 9:16 AM
Super excited to join @ahajournals.bsky.social Hypertension as an #ECR editorial assistant!
Reposted by Rikeish R Muralitharan MD, PhD
Interesting breakdown by @fzmarques.bluesky.social & @rikeish.bsky.social on how the gut #microbiome shapes #bloodpressure of their paper published in #CircRes.
📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/�#Hypertensionrtension @ahajournals.bsky.social
📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/�#Hypertensionrtension @ahajournals.bsky.social
February 4, 2025 at 3:20 AM
Interesting breakdown by @fzmarques.bluesky.social & @rikeish.bsky.social on how the gut #microbiome shapes #bloodpressure of their paper published in #CircRes.
📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/�#Hypertensionrtension @ahajournals.bsky.social
📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/�#Hypertensionrtension @ahajournals.bsky.social
I am super proud and excited to share my latest publication, out now in @ahajournals.bsky.social (www.ahajournals.org/doi/10.1161/...)
Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research
BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites
called short-chain fatty acids, which lower blood pressure and exert cardioprotective
effects. Sh...
www.ahajournals.org
January 30, 2025 at 3:59 AM
I am super proud and excited to share my latest publication, out now in @ahajournals.bsky.social (www.ahajournals.org/doi/10.1161/...)
Reposted by Rikeish R Muralitharan MD, PhD
The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access
January 23, 2025 at 7:08 PM
The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access
Reposted by Rikeish R Muralitharan MD, PhD
The gut microbiome products and.....
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...
January 13, 2025 at 7:33 PM
The gut microbiome products and.....
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...
Reposted by Rikeish R Muralitharan MD, PhD
🔔🧪 #Women, even in well-represented #scientific fields, are up to 40% more likely than men to leave #research within 20 years (Nature News). Urgent #action is needed to close the #scissor-shaped curve.
#WomenInSTEM #genderequity #diversity #STEM
www.nature.com/articles/d41...
Who’s quitting academia? Data reveal gender gaps in surprising fields
Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.
www.nature.com
January 14, 2025 at 10:59 AM
🔔🧪 #Women, even in well-represented #scientific fields, are up to 40% more likely than men to leave #research within 20 years (Nature News). Urgent #action is needed to close the #scissor-shaped curve.
#WomenInSTEM #genderequity #diversity #STEM
www.nature.com/articles/d41...
Reposted by Rikeish R Muralitharan MD, PhD
Yes, #SciComm is really underestimated and many researchers are failing still (No you aren't "smarter" when using lots of jargon!) 🧪 make research accessible!
Good essay, and it applies to public health communication, as well.
"The gap between scientific understanding and public reception seems to widen with each passing crisis....our expertise has become a barrier rather than a bridge."
"The gap between scientific understanding and public reception seems to widen with each passing crisis....our expertise has become a barrier rather than a bridge."
ICYMI a great #scicomm piece from @unbiasedscipod.bsky.social this week.
It resonates - perhaps partly because I try to publicly communicate as if I'm talking to my grandma or high school friends.
What do you all think?🛟🧪🩺
theunbiasedscipod.substack.com/p/the-cost-o...
It resonates - perhaps partly because I try to publicly communicate as if I'm talking to my grandma or high school friends.
What do you all think?🛟🧪🩺
theunbiasedscipod.substack.com/p/the-cost-o...
January 14, 2025 at 7:20 AM
Yes, #SciComm is really underestimated and many researchers are failing still (No you aren't "smarter" when using lots of jargon!) 🧪 make research accessible!
Why are microbiome studies poorly translated or reproducible?
We wrote an editorial to highlight the importance of considering and minimizing confounder effect in gut microbiome studies. @fzmarques.bsky.social @monashbiol.bsky.social
academic.oup.com/cardiovascre...
We wrote an editorial to highlight the importance of considering and minimizing confounder effect in gut microbiome studies. @fzmarques.bsky.social @monashbiol.bsky.social
academic.oup.com/cardiovascre...
January 14, 2025 at 1:25 AM
Why are microbiome studies poorly translated or reproducible?
We wrote an editorial to highlight the importance of considering and minimizing confounder effect in gut microbiome studies. @fzmarques.bsky.social @monashbiol.bsky.social
academic.oup.com/cardiovascre...
We wrote an editorial to highlight the importance of considering and minimizing confounder effect in gut microbiome studies. @fzmarques.bsky.social @monashbiol.bsky.social
academic.oup.com/cardiovascre...
Reposted by Rikeish R Muralitharan MD, PhD
Another day, another paper 🙃
This paper was inspired by my journey as a cancer patient & the type of leader I am in the journey of trying to become
A great read to start the year aiming to drive a more positive, equitable, and diverse research culture
www.ahajournals.org/doi/10.1161/...
This paper was inspired by my journey as a cancer patient & the type of leader I am in the journey of trying to become
A great read to start the year aiming to drive a more positive, equitable, and diverse research culture
www.ahajournals.org/doi/10.1161/...
Rethinking Culture to Unlock the Potential of Medical Research | Hypertension
www.ahajournals.org
January 8, 2025 at 11:04 PM
Another day, another paper 🙃
This paper was inspired by my journey as a cancer patient & the type of leader I am in the journey of trying to become
A great read to start the year aiming to drive a more positive, equitable, and diverse research culture
www.ahajournals.org/doi/10.1161/...
This paper was inspired by my journey as a cancer patient & the type of leader I am in the journey of trying to become
A great read to start the year aiming to drive a more positive, equitable, and diverse research culture
www.ahajournals.org/doi/10.1161/...
Reposted by Rikeish R Muralitharan MD, PhD
Research Rockstar Award 🏆
For achieving the highest number of peer-reviewed recognition (across awards and papers)
Nominees: everyone! Total of 54 awards
Runner up: Charlotte Barker (10 awards)
Winners: @mattsnelson.bsky.social and @rikeish.bsky.social (11 awards or 1st/last author papers each)
For achieving the highest number of peer-reviewed recognition (across awards and papers)
Nominees: everyone! Total of 54 awards
Runner up: Charlotte Barker (10 awards)
Winners: @mattsnelson.bsky.social and @rikeish.bsky.social (11 awards or 1st/last author papers each)
December 15, 2024 at 9:25 PM
Research Rockstar Award 🏆
For achieving the highest number of peer-reviewed recognition (across awards and papers)
Nominees: everyone! Total of 54 awards
Runner up: Charlotte Barker (10 awards)
Winners: @mattsnelson.bsky.social and @rikeish.bsky.social (11 awards or 1st/last author papers each)
For achieving the highest number of peer-reviewed recognition (across awards and papers)
Nominees: everyone! Total of 54 awards
Runner up: Charlotte Barker (10 awards)
Winners: @mattsnelson.bsky.social and @rikeish.bsky.social (11 awards or 1st/last author papers each)
Reposted by Rikeish R Muralitharan MD, PhD
#ecrchat #phdchat #womeninSTEM #womeninleadership #researchculture #workplaceculture #phdlife #labawards @monashuniversity.bsky.social @monashbiol.bsky.social
Every year, we have lab awards 🏆 to celebrate helping behaviours across our team, which are essential in creating a positive workplace culture 🥳
The team then votes, and all nominees are mentioned in our Xmas party (photo below, missing some people)
Here are the 2024 nominees and winners
The team then votes, and all nominees are mentioned in our Xmas party (photo below, missing some people)
Here are the 2024 nominees and winners
December 15, 2024 at 9:28 PM
The CV sector has created a joint submission for the @nhmrc urging them to reconsider the proposed changes to the eligibility requirement for Emerging Leadership (EL) applicants. Please read and make your own submission before Dec 4
ozheart.org/joint-submis...
ozheart.org/joint-submis...
Joint submission on the proposed NHMRC updates to the Investigator Grant eligibility
The public consultation by the National Health and Medical Research Council (NHMRC) on proposed updates to the Investigator and Synergy Grant assessment framewo
ozheart.org
December 3, 2024 at 5:08 AM
The CV sector has created a joint submission for the @nhmrc urging them to reconsider the proposed changes to the eligibility requirement for Emerging Leadership (EL) applicants. Please read and make your own submission before Dec 4
ozheart.org/joint-submis...
ozheart.org/joint-submis...
Reposted by Rikeish R Muralitharan MD, PhD
Congratulations to our team members at ☺️#Hypertension Australia 🤩
Dr Joanne O’Donnell - winner of the Judith Withworth Award for highest ranked abstract by a female first author
Evany Dinakis - winner of the Student Oral Award (project funded by Heart Foundation)
#hypertensionASM2024
Dr Joanne O’Donnell - winner of the Judith Withworth Award for highest ranked abstract by a female first author
Evany Dinakis - winner of the Student Oral Award (project funded by Heart Foundation)
#hypertensionASM2024
November 29, 2024 at 4:11 AM
Congratulations to our team members at ☺️#Hypertension Australia 🤩
Dr Joanne O’Donnell - winner of the Judith Withworth Award for highest ranked abstract by a female first author
Evany Dinakis - winner of the Student Oral Award (project funded by Heart Foundation)
#hypertensionASM2024
Dr Joanne O’Donnell - winner of the Judith Withworth Award for highest ranked abstract by a female first author
Evany Dinakis - winner of the Student Oral Award (project funded by Heart Foundation)
#hypertensionASM2024
Reposted by Rikeish R Muralitharan MD, PhD
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
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Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
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