Ric Price
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ricprice99.bsky.social
Ric Price
@ricprice99.bsky.social
Global Health | Infectious Diseases | Physician practising in the tropical north of Australia | Clinical Researcher
#IDSky #malaria #vivax
https://www.menzies.edu.au/page/Our_People/Researchers/Ric_Price
Reposted by Ric Price
The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky
April 12, 2025 at 3:09 PM
Reposted by Ric Price
We need facts as never before.

3 years after Putin invaded Ukraine, I spent 24 hours with combat medics on the Ukrainian frontline.

Their courage, compassion, dedication & skill are astounding.

Please read & please never stop standing up for Ukraine. 🇺🇦

www.theguardian.com/world/2025/f...
‘We have a rule when we hear the sirens: if you’ve started operating, you don’t stop’: 24 hours with doctors on the Ukrainian frontline
Like the soldiers they battle to save, combat medics in Ukraine are under constant attack. Three years after the invasion, one NHS doctor bears witness
www.theguardian.com
February 22, 2025 at 8:19 AM
Reposted by Ric Price
More than half of the Gm-negative infections in soldiers in the Ukraine conflict are resistant to carbapenems - fascinating presentation on #AMR in conflict settings from @catanita.bsky.social
#antimicrobials2025 #ASA2025 #globalpublichealth #MDRI
February 20, 2025 at 12:16 AM
Reposted by Ric Price
📣 Medical editors call for #action against the decisions being taken in the #USA undermining #medicine and #science, and international #coordination to preserve what has been built across borders.

#IDSky #Clinmicro #MedSky #Episky #publichealth #vaccines

www.cmi-comms.com/article/S295...
From medical editors: A call to the global infectious diseases and clinical microbiology community
Each time a man stands up for an ideal, or acts to improve the lot of others, or strikes out against injustice, he sends forth a tiny ripple of hope.Robert F. Kennedy, Senior
www.cmi-comms.com
February 5, 2025 at 7:38 AM
Reposted by Ric Price
Are you researching #malaria? The datasets we host harmonise tens of thousands of individual patient data, enabling researchers to answer new questions from existing data. Learn more www.iddo.org/wwarn/w...
#DataReuse #DataForGood
January 23, 2025 at 7:14 AM
Modelling paper using data from prospective clinical trials highlights major impact of higher doses of primaquine and tafenoquine on P.vivax recurrences and #vivax transmission. Coverage, adherence and safety will be key elements in implementation.
www.thelancet.com/journals/lan...
Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics
Substantial reductions in prevalence as measured by PCR were predicted with primaquine and tafenoquine regimens if these could be implemented with high coverage and adherence. The benefits of preventi...
www.thelancet.com
January 19, 2025 at 11:00 AM
Understanding the factors affecting patient adherence to primaquine treatment will inform better interventions targeting #vivax radical cure. This study from Thai-Myanmar border provides great insights.
journals.plos.org/globalpublic...
A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border
Background The countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cur...
journals.plos.org
January 19, 2025 at 10:53 AM
Clinical trial in Cambodia, once again highlighting that higher total doses of primaquine (7mg/kg) are needed to achieve high antirelapse cure rates in patients with #vivax malaria. Plus reassuring safety data.
www.medrxiv.org/content/10.1...
High versus low dose of 14 days treatment of primaquine in Plasmodium vivax infected patients in Cambodia: a randomised open-label efficacy study
Background The WHO malaria treatment guidelines recommend a total dose in the range of 3·5 to 7·0 mg/kg of primaquine to eliminate Plasmodium vivax ( P. vivax ) hypnozoites and prevent relapses. There...
www.medrxiv.org
January 19, 2025 at 10:49 AM
Poverty is one of biggest determinants of outcome from #TB . Cases & mortality in impoverished communities were halved by the Brazilian Bolsa Família (conditional cash transfer). Non randomised cohort study, but great results.
www.nature.com/articles/s41...
Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort - Nature Medicine
Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among ...
www.nature.com
January 4, 2025 at 3:20 PM
AKI following SAB occured in 48% and associated with 28 day mortality (OR=3.8).
"Some AKI phenotypes have rapid resolution, which supports consideration of delayed antimicrobial dose reduction." @gurujosh.bsky.social
🆕💫Retrospective cohort study #CMI
AKI is a frequent complication of S. aureus bacteraemia and is associated with 30-day mortality
Not “a cute” complication: phenotypic analysis of acute kidney injury in S. aureus bacteraemia #idsky #EMIMCC
www.clinicalmicrobiologyandinfection.com/article/S119...
DEFINE_ME
www.clinicalmicrobiologyandinfection.com
December 31, 2024 at 8:04 AM
Reposted by Ric Price
Outbreak of yellow fever in the Americas Region:24 deaths out of 50 confirmed cases. On this International Day of #EpidemicPreparedness we are reminded of the risk of re-emergence of old threats and the importance of #research
and #vaccination @yellow4flavi.bsky.social

www.paho.org/sites/defaul...
December 27, 2024 at 7:59 PM
Researching #malaria in pregnancy? Check out the malaria in pregnancy library, an online resource to search published and unpublished literature @wwarnnews.bsky.social
www.iddo.org/wwarn/malari...
Malaria in Pregnancy Library | Infectious Diseases Data Observatory
www.iddo.org
December 30, 2024 at 7:29 PM
Reposted by Ric Price
Jimmy Carter
December 29, 2024 at 10:09 PM
Fungal pathogens not constrained to previously considered endemic areas.
December 30, 2024 at 4:59 AM
Latest "WHO Guidelines for Malaria" finally published. 460+ pages with recommendations spanning vector control, treatment, vaccination, chemoprevention and elimination strategies.
Several major changes for radical cure of #vivax #malaria
www.who.int/publications...
WHO guidelines for malaria
The WHO Guidelines for malaria bring together the Organization’s most up-to-date recommendations for malaria in one easy-to-navigate online platform
www.who.int
December 28, 2024 at 5:25 AM
Rise of tinae corporis due to Trichophyton indotinae esp in patients linked to South Asia. High rates of terbinafine resistance and 5% poor response to itraconazole
wwwnc.cdc.gov/eid/article/...
Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024
Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024
wwwnc.cdc.gov
December 27, 2024 at 5:07 PM
Suboptimal mg/kg dosing of CQ and PQ is a major factor in treatment failure for #vivax malaria
jkms.org/DOIx.php?id=...
Suboptimal Doses of Antimalarials Relative to Increasing Body Weight and the Risk of Plasmodium vivax Recurrence in the Republic of Korea Armed Forces, 2012–2021
Hwang YH, et al. J Korean Med Sci. 2024 Oct;39(49):e314. https://doi.org/10.3346/jkms.2024.39.e314
jkms.org
December 27, 2024 at 3:19 PM
AL reduces #malaria transmission far more than AS-AQ in West Africa. Plus reminder of major benefits of single low dose primaquine
www.sciencedirect.com/science/arti...
Artemether–lumefantrine–amodiaquine or artesunate–amodiaquine combined with single low-dose primaquine to reduce Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a five-arm, phase 2...
Triple artemisinin-based combination therapies (TACTs) can delay the spread of antimalarial drug resistance. Artesunate–amodiaquine is widely used for…
www.sciencedirect.com
December 27, 2024 at 3:05 PM
Reposted by Ric Price
Antibiotic use increased 16.3% since 2016, driven largely by economic growth in LMIC. Despite concerns on AMR, effective measures like stewardship programs, public awareness, improved infection prevention have helped some high-income nations limit their consumption.

www.pnas.org/doi/10.1073/...
Global trends in antibiotic consumption during 2016–2023 and future projections through 2030 | PNAS
Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant ...
www.pnas.org
December 26, 2024 at 9:54 AM
Reposted by Ric Price
It's that time of year again. Here are my top 10 ID papers of 2024
1. My opinion
2. Practice changing, paradigm-shifting or dogma challenging
3. Not COVID
4. Alphabetical order by first author
5. CoI for 4 and 5 (I am an author)
Summary slide here, details in thread
#IDSky #Top10IDpapers
December 23, 2024 at 2:42 AM
The new WWARN #Vivax library contains data from 301 clinical trials, & case reports from 433 sites published since 1960 across 39 countries. Use it free for your #Malaria research
www.iddo.org/wwarn/wwarn-...
https://iddo.org/wwarn/wwarn-vi…
December 19, 2024 at 7:26 PM
RTS/S, R21 and now hopefully RH5 not too far behind. Promising results of Phase 2b trial in Burkina Faso especially in high density infections. But unknown longevity www.thelancet.com/journals/lan...
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children
RH5.1/Matrix-M appears safe and highly immunogenic in African children and shows promising efficacy against clinical malaria when given in a delayed third-dose regimen. This trial is ongoing to further monitor efficacy over time.
www.thelancet.com
December 16, 2024 at 4:30 PM
Reposted by Ric Price
24 strains of S. maltophilia were treated with Cefiderocol which is the largest real-life series to date
The results confirm real-world efficacy of Cefiderocol in S. matlophilia infections, for which therapeutic armamentarium is limited #idsky #EMIMCC
December 14, 2024 at 5:56 PM