Renato Polimanti
@renatopolimanti.bsky.social
Human Genetics, Molecular Epidemiology, Biological Psychiatry
https://medicine.yale.edu/lab/polimanti/
https://medicine.yale.edu/lab/polimanti/
Pinned
Updated #PolimanTEAM picture! Potluck with delicious dishes from around the 🌎. Very thankful to an amazing group advancing #science by bringing together their different perspectives! #ThisIsWhatScientistsLookLike
Reposted by Renato Polimanti
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
November 13, 2025 at 11:26 AM
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Reposted by Renato Polimanti
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Renato Polimanti
You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG
November 10, 2025 at 7:47 PM
You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG
Reposted by Renato Polimanti
Reposted by Renato Polimanti
Day three of #ASHG25 is complete! ✔️
For today’s highlights we:
💡Soaked up insights from today’s scientific sessions
🏅Celebrated the excellence of our outstanding awardees
🔗Connected & collaborated with fellow attendees
See you tomorrow for day four!
For today’s highlights we:
💡Soaked up insights from today’s scientific sessions
🏅Celebrated the excellence of our outstanding awardees
🔗Connected & collaborated with fellow attendees
See you tomorrow for day four!
October 17, 2025 at 12:32 AM
Day three of #ASHG25 is complete! ✔️
For today’s highlights we:
💡Soaked up insights from today’s scientific sessions
🏅Celebrated the excellence of our outstanding awardees
🔗Connected & collaborated with fellow attendees
See you tomorrow for day four!
For today’s highlights we:
💡Soaked up insights from today’s scientific sessions
🏅Celebrated the excellence of our outstanding awardees
🔗Connected & collaborated with fellow attendees
See you tomorrow for day four!
Reposted by Renato Polimanti
“We must keep going with this ability to sample genomes, not just in the convenient places we started out with.” - former Director of the National Institutes of Health, Francis Collins, MD, PhD, during his recognition speech at #ASHG25
October 14, 2025 at 9:11 PM
“We must keep going with this ability to sample genomes, not just in the convenient places we started out with.” - former Director of the National Institutes of Health, Francis Collins, MD, PhD, during his recognition speech at #ASHG25
Reposted by Renato Polimanti
Thanks to @geneticssociety.bsky.social, if you are coming early to #ASHG25 you can show your badge at the Boston Museum of Science and get in free! Stop by for your badge first and then head over if you are not going to any of the workshops, before Sarah Tishkoff’s presidential address at 4:30pm.
October 13, 2025 at 1:40 PM
Thanks to @geneticssociety.bsky.social, if you are coming early to #ASHG25 you can show your badge at the Boston Museum of Science and get in free! Stop by for your badge first and then head over if you are not going to any of the workshops, before Sarah Tishkoff’s presidential address at 4:30pm.
Reposted by Renato Polimanti
⏰ TODAY at NOON ET, we’re giving you all the details you'll need to make your #ASHG25 experience in Boston one to beat! Join our webinar for:
✅Pro tips on navigating the event
✅Live Q&A
✅Must-have resources
Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG
✅Pro tips on navigating the event
✅Live Q&A
✅Must-have resources
Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG
October 1, 2025 at 1:26 PM
⏰ TODAY at NOON ET, we’re giving you all the details you'll need to make your #ASHG25 experience in Boston one to beat! Join our webinar for:
✅Pro tips on navigating the event
✅Live Q&A
✅Must-have resources
Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG
✅Pro tips on navigating the event
✅Live Q&A
✅Must-have resources
Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG
Reposted by Renato Polimanti
Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...
August 20, 2025 at 5:47 PM
Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...
Reposted by Renato Polimanti
🚨It’s now or never!
Today’s your last chance to save on the event bringing human genetics and genomics professionals together.
Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25...
#ASHG
Today’s your last chance to save on the event bringing human genetics and genomics professionals together.
Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25...
#ASHG
August 6, 2025 at 2:08 PM
🚨It’s now or never!
Today’s your last chance to save on the event bringing human genetics and genomics professionals together.
Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25...
#ASHG
Today’s your last chance to save on the event bringing human genetics and genomics professionals together.
Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25...
#ASHG
Reposted by Renato Polimanti
"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
July 21, 2025 at 2:20 PM
"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Reposted by Renato Polimanti
Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:41 PM
Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:
Reposted by Renato Polimanti
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:47 PM
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
Reposted by Renato Polimanti
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
June 17, 2025 at 12:46 PM
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
🚨Our new study, led by Jun He, is out on @alzdemjournals.bsky.social! Leveraging @ukbiobank.bsky.social and #AllofUs, we uncovered sex-specific effects of socioeconomic and cognitive factors on the assessment of #alzheimers family history.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
INTRODUCTION Limited information is available regarding sex differences in the relationship of socioeconomic status and cognitive performance with Alzheimer's disease and related dementias (ADRD) fa...
alz-journals.onlinelibrary.wiley.com
May 27, 2025 at 1:39 PM
🚨Our new study, led by Jun He, is out on @alzdemjournals.bsky.social! Leveraging @ukbiobank.bsky.social and #AllofUs, we uncovered sex-specific effects of socioeconomic and cognitive factors on the assessment of #alzheimers family history.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Renato Polimanti
Submitting an abstract for the first time or needing a refresher on the process? We've got you covered! When you submit an abstract to #ASHG25, you'll go from preparation to notification in just 6 steps.
📌Save this post for later
🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG
📌Save this post for later
🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG
May 16, 2025 at 4:57 PM
Submitting an abstract for the first time or needing a refresher on the process? We've got you covered! When you submit an abstract to #ASHG25, you'll go from preparation to notification in just 6 steps.
📌Save this post for later
🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG
📌Save this post for later
🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG
Reposted by Renato Polimanti
That's right – registration is open for #ASHG25!🧬Follow the link below to secure your spot and join us in Boston, MA for five days of scientific and industry excellence. We can't wait to see you there!
🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics
🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics
April 18, 2025 at 5:51 PM
That's right – registration is open for #ASHG25!🧬Follow the link below to secure your spot and join us in Boston, MA for five days of scientific and industry excellence. We can't wait to see you there!
🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics
🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics
Reposted by Renato Polimanti
Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis
👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social
👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social
Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis, según un nuevo estudio - Mujeres con ciencia
Endometriosis. Experiencias traumáticas. Genética. Enfermedad inflamatoria crónica. Enfermedad sistémica.
mujeresconciencia.com
April 18, 2025 at 8:02 AM
Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis
👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social
👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social
Reposted by Renato Polimanti
Join "Mendelian Randomization for Causal Inference: Genetically Informed Causal Inference Through #MendelianRandomization and Other Approaches" with @renatopolimanti.bsky.social on April 9-11! Discover how genetic variation can uncover #causal relationships in large-scale datasets.
Mendelian Randomization for Causal Inference | Statistics Course
This seminar by Renato Polimanti provides a comprehensive theoretical background regarding the integration of causal inference and human genetics.
statisticalhorizons.com
March 21, 2025 at 1:27 PM
Join "Mendelian Randomization for Causal Inference: Genetically Informed Causal Inference Through #MendelianRandomization and Other Approaches" with @renatopolimanti.bsky.social on April 9-11! Discover how genetic variation can uncover #causal relationships in large-scale datasets.
Reposted by Renato Polimanti
I love this photo that @melissabender.bsky.social captured of me at the #standupforscience rally yesterday in NYC. I wonder if I could make this my official faculty photo lol @jackiantonovich.bsky.social @kimberlywheiman.bsky.social @archaeoscape.bsky.social @sarahruncie.bsky.social
March 8, 2025 at 12:50 PM
I love this photo that @melissabender.bsky.social captured of me at the #standupforscience rally yesterday in NYC. I wonder if I could make this my official faculty photo lol @jackiantonovich.bsky.social @kimberlywheiman.bsky.social @archaeoscape.bsky.social @sarahruncie.bsky.social
Reposted by Renato Polimanti
Transgenic mice are widely used in cancer research to study tumor development, genetic mutations, and potential treatments. TRANSGENIC
March 6, 2025 at 9:14 PM
Transgenic mice are widely used in cancer research to study tumor development, genetic mutations, and potential treatments. TRANSGENIC
Reposted by Renato Polimanti
Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses https://www.medrxiv.org/content/10.1101/2025.02.28.25323099v1
March 5, 2025 at 3:12 AM
Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses https://www.medrxiv.org/content/10.1101/2025.02.28.25323099v1
Reposted by Renato Polimanti
🔥Some Predictions about the NIH situation, NIH budget cuts
🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14.
🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)
🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14.
🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)
March 1, 2025 at 9:34 PM
🔥Some Predictions about the NIH situation, NIH budget cuts
🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14.
🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)
🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14.
🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)
Reposted by Renato Polimanti
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Microsoft Forms
forms.office.com
February 22, 2025 at 8:12 PM
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Reposted by Renato Polimanti
Women with endometriosis are more likely to experience childhood and adulthood traumas, independently of genetic predisposition.
by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky
📖 read the article:
by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky
📖 read the article:
Observational and Genetic Analyses of Traumatic Experiences and Endometriosis
This case-control study analyzes genotypic and phenotypic information from individual-level UK Biobank data, along with genome-wide information from a large meta-analysis and the FinnGen cohort, to determine the relationship between traumatic experiences and endometriosis.
jamanetwork.com
February 14, 2025 at 6:35 AM
Women with endometriosis are more likely to experience childhood and adulthood traumas, independently of genetic predisposition.
by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky
📖 read the article:
by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky
📖 read the article: