Jüri Reimand
@reimand.bsky.social
Computational biology, cancer research. assoc prof at University of Toronto, PI at OICR. Opinions my own. 🇨🇦🇪🇪
Pinned
Jüri Reimand
@reimand.bsky.social
· Sep 5
Cancer genomic alterations and microenvironmental features encode synergistic interactions with disease outcomes
Abstract. Oncogenesis, tumor progression and therapy response are shaped by somatic alterations in the cancer genome and features of the tumor immune microenvironment (TME). How interactions between t...
aacrjournals.org
Congrats to our PhD student Masroor Bayati for his first-author publication out this week. We developed a computational method to map synergistic interactions in omics datasets and studied prognostic signals of co-occurring cancer driver alterations and TME features. aacrjournals.org/mcr/article/...
Better DNA repair machinery protects one of the largest mammals from cancer: www.nature.com/articles/s41... 🐋
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 31, 2025 at 2:16 AM
Better DNA repair machinery protects one of the largest mammals from cancer: www.nature.com/articles/s41... 🐋
Reposted by Jüri Reimand
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200
Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.
www.nature.com
October 28, 2025 at 10:06 PM
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
made my first meme to celebrate the never-boring pathway to publication. #PIlyfe #openaccess
September 10, 2025 at 5:48 PM
made my first meme to celebrate the never-boring pathway to publication. #PIlyfe #openaccess
Excited to see this study led by Nick Min & Xi Huang published this week and grateful for a decade of collaborations : www.nature.com/articles/s41...
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis - Nature Biomedical Engineering
Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.
www.nature.com
September 5, 2025 at 3:28 PM
Excited to see this study led by Nick Min & Xi Huang published this week and grateful for a decade of collaborations : www.nature.com/articles/s41...
Congrats to our PhD student Masroor Bayati for his first-author publication out this week. We developed a computational method to map synergistic interactions in omics datasets and studied prognostic signals of co-occurring cancer driver alterations and TME features. aacrjournals.org/mcr/article/...
Cancer genomic alterations and microenvironmental features encode synergistic interactions with disease outcomes
Abstract. Oncogenesis, tumor progression and therapy response are shaped by somatic alterations in the cancer genome and features of the tumor immune microenvironment (TME). How interactions between t...
aacrjournals.org
September 5, 2025 at 3:26 PM
Congrats to our PhD student Masroor Bayati for his first-author publication out this week. We developed a computational method to map synergistic interactions in omics datasets and studied prognostic signals of co-occurring cancer driver alterations and TME features. aacrjournals.org/mcr/article/...
Reposted by Jüri Reimand
Hey everybody! @drjuliawester.bsky.social and I have a new paper!
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky
Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For
doi.org
August 19, 2025 at 2:34 PM
Hey everybody! @drjuliawester.bsky.social and I have a new paper!
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
Reposted by Jüri Reimand
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
July 25, 2025 at 3:46 PM
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95
GitHub - reimandlab/ActivePathways: Integrative pathway enrichment analysis of multivariate omics data
Integrative pathway enrichment analysis of multivariate omics data - reimandlab/ActivePathways
github.com
August 9, 2025 at 4:42 PM
We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95
meticulously delve into intricate this
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024. scim.ag/3IhpoQF
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Excess words track LLM usage in biomedical publications.
scim.ag
July 9, 2025 at 7:32 PM
meticulously delve into intricate this
Another great collaboration with Carolina Nor & Michael Taylor: Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. @abahcheli.bsky.social led our omics integration via pathway analyses. @cp-devcell.bsky.social www.cell.com/developmenta...
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process
Radiation, the most effective treatment for medulloblastoma, induces an innate immune
response and opens the blood-brain barrier, allowing for the intravasation of tumor
cells into the blood circulati...
www.cell.com
July 8, 2025 at 10:55 AM
Another great collaboration with Carolina Nor & Michael Taylor: Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. @abahcheli.bsky.social led our omics integration via pathway analyses. @cp-devcell.bsky.social www.cell.com/developmenta...
Reposted by Jüri Reimand
From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.
We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky
www.nature.com/articles/d41...
We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky
www.nature.com/articles/d41...
Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
www.nature.com
June 16, 2025 at 8:29 PM
From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.
We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky
www.nature.com/articles/d41...
We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky
www.nature.com/articles/d41...
Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience
In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...
www.nature.com
June 16, 2025 at 2:25 PM
Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...
very happy to have contributed to this collaboration with the Taylor lab - with integrative pathway analyses & rich network visualizations led by our PhD student @abahcheli.bsky.social
💫NEW: Taylor & co report that the presence of leptomeningeal metastatic #tumor cells leads to the recruitment and remodeling of #fibroblasts, which, in turn, facilitate the colonization and outgrowth of #medulloblastoma cells in the leptomeninges.
bit.ly/3ESVYac
bit.ly/3ESVYac
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth - Nature Cell Biology
Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonizat...
bit.ly
May 9, 2025 at 3:42 PM
very happy to have contributed to this collaboration with the Taylor lab - with integrative pathway analyses & rich network visualizations led by our PhD student @abahcheli.bsky.social
Reposted by Jüri Reimand
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
April 19, 2025 at 12:12 PM
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
Reposted by Jüri Reimand
George R. R. Martin on @biorxiv-evobio.bsky.social!
April 11, 2025 at 11:43 PM
George R. R. Martin on @biorxiv-evobio.bsky.social!
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer - using a spit test www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM
The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific
antigen (PSA) has a high rate for false positive results. Genomewide association studies
have identified...
www.nejm.org
April 10, 2025 at 5:07 AM
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer - using a spit test www.nejm.org/doi/full/10....
enjoyed this thought-provoking essay: The end of the genetic paradigm of cancer
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...
journals.plos.org
March 25, 2025 at 3:28 PM
enjoyed this thought-provoking essay: The end of the genetic paradigm of cancer
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Jüri Reimand
We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!
Mid-Career to Senior Principal Investigator
About OICR
OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...
oicr.bamboohr.com
February 4, 2025 at 4:05 PM
We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!