prudenciolab.bsky.social
@prudenciolab.bsky.social
Reposted
Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies - Molecular Neurodegeneration
Background Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the mec...
molecularneurodegeneration.biomedcentral.com
March 13, 2025 at 10:56 PM
I was thrilled for the opportunity to present today #ADPD2025 the work @PrudencioLab, in the wonderful city of Vienna where I was lucky to get an awesome tour by Dr Wilfried Rossoll! @rossolllab.bsky.social
April 5, 2025 at 11:09 AM
April 3, 2025 at 4:17 PM
Excited to finally publish our work on cryptic splicing in Perry syndrome. Moreover, it higlights that not all cryptic RNAs are detected in every brain region with TDP-43 pathology. Enjoy!

movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
TDP‐43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP‐43 Proteinopathies
In Perry syndrome caudate nucleus, TDP-43 pathology and dysfunction lead to the cryptic splicing of eight RNA targets as well as HDGFL2 cryptic protein. In the substantia nigra, only one cryptic targ....
movementdisorders.onlinelibrary.wiley.com
January 10, 2025 at 11:42 PM