Dr Poonam Thakur
@poonamthakur.bsky.social
Assistant Professor at IISER-Thiruvananthapuram, India. Working on the neurobiology of Parkinson's disease using mouse models. https://sites.google.com/view/thakurlab/home
Pleased to share our new publication in Bioprotocol, where we describe a detailed method for generating the progressive #mouse model of #Parkinson’s disease combining rAAV-α-synuclein and preformed fibrils of α-synuclein. We hope this serves as a useful resource. bio-protocol.org/en/bpdetail?....
A One-Step Mouse Model of Parkinson’s Disease Combining rAAV-α-Synuclein and Preformed Fibrils of α-Synuclein
Developing preclinical animal models that faithfully mimic the progressive nature of Parkinson’s disease (PD) is crucial for advancing mechanistic insights as well as therapeutic discovery. While reco...
bio-protocol.org
November 7, 2025 at 2:00 PM
Pleased to share our new publication in Bioprotocol, where we describe a detailed method for generating the progressive #mouse model of #Parkinson’s disease combining rAAV-α-synuclein and preformed fibrils of α-synuclein. We hope this serves as a useful resource. bio-protocol.org/en/bpdetail?....
Our latest study explores how lipid dysregulation links the brain and periphery in #Parkinson’s disease (PD). #Lipid imbalance is emerging as a hallmark of PD—but do peripheral lipid changes truly mirror what happens in the brain?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson′s disease
Lipid dysregulation is increasingly recognized as a key feature of Parkinson′s disease (PD). A central unresolved question, however, is whether lipidomic signatures identified in accessible peripheral...
www.biorxiv.org
October 4, 2025 at 7:31 AM
Our latest study explores how lipid dysregulation links the brain and periphery in #Parkinson’s disease (PD). #Lipid imbalance is emerging as a hallmark of PD—but do peripheral lipid changes truly mirror what happens in the brain?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Can neurons bounce back after damage? A new study in @elife.bsky.social reveals that surviving dopamine SN neurons can restore full firing flexibility—once thought lost—with Kv4.3-mediated changes. Happy to have contributed to this seminal work. elifesciences.org/articles/104...
Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity
elifesciences.org
September 23, 2025 at 4:00 AM
Can neurons bounce back after damage? A new study in @elife.bsky.social reveals that surviving dopamine SN neurons can restore full firing flexibility—once thought lost—with Kv4.3-mediated changes. Happy to have contributed to this seminal work. elifesciences.org/articles/104...
Excited to share our new paper in ACS Chemical Neuroscience. Through biophysical assays and in vivo studies, we show that glycation alters how α-synuclein drives pathology, leading to earlier symptom onset. This may help explain the higher PD risk in people with diabetes pubs.acs.org/doi/full/10....
Glycated Alpha-Synuclein Assemblies Cause Distinct Parkinson’s Disease Pathogenesis in Mice
Alpha-synuclein (α-Syn) misfolding and aggregation are key drivers of Parkinson’s disease (PD) pathology. Mutations and certain post-translational modifications impact its aggregation propensity and p...
pubs.acs.org
September 13, 2025 at 5:36 AM
Excited to share our new paper in ACS Chemical Neuroscience. Through biophysical assays and in vivo studies, we show that glycation alters how α-synuclein drives pathology, leading to earlier symptom onset. This may help explain the higher PD risk in people with diabetes pubs.acs.org/doi/full/10....
Thrilled to kick off our collaboration with @kmcostalab.com, supported by an Impact Award from @pfresearchteam.bsky.social. We will uncover how striatal dopamine contributes to cognitive decline in early stages of #Parkinsonsdisease. Exciting times ahead!
@tvmiiser @bio_iisertvm
@tvmiiser @bio_iisertvm
The lab has received a Parkinson's Foundation Impact Award!
Together with @poonamthakur.bsky.social, we will explore how dopamine signaling changes in early PD impacts cognition. We are honored and grateful for this opportunity!
proposalcentral.com/Insights/E_E...
@parkinsondotorg.bsky.social
Together with @poonamthakur.bsky.social, we will explore how dopamine signaling changes in early PD impacts cognition. We are honored and grateful for this opportunity!
proposalcentral.com/Insights/E_E...
@parkinsondotorg.bsky.social
August 27, 2025 at 4:32 AM
Thrilled to kick off our collaboration with @kmcostalab.com, supported by an Impact Award from @pfresearchteam.bsky.social. We will uncover how striatal dopamine contributes to cognitive decline in early stages of #Parkinsonsdisease. Exciting times ahead!
@tvmiiser @bio_iisertvm
@tvmiiser @bio_iisertvm
Grateful to @cureparkinsons.org.uk for this feature on #ResearchAppreciationDay & their continued support for our preclinical research program for #Parkinsons. Their commitment to advancing fundamental research that can inform future therapeutic strategies for PD is commendable. 🙏
This #ResearchAppreciationDay, we’re launching our Meet the Researcher series!
In this interview, Assistant Professor Dr Poonam Thakur discusses studying repurposed drugs for Cure Parkinson’s, and why it's vital for scientists to engage with the public: buff.ly/7Yq3N34
In this interview, Assistant Professor Dr Poonam Thakur discusses studying repurposed drugs for Cure Parkinson’s, and why it's vital for scientists to engage with the public: buff.ly/7Yq3N34
July 6, 2025 at 6:28 AM
Grateful to @cureparkinsons.org.uk for this feature on #ResearchAppreciationDay & their continued support for our preclinical research program for #Parkinsons. Their commitment to advancing fundamental research that can inform future therapeutic strategies for PD is commendable. 🙏
I will be attending the Synuclein2025 meeting at Cambridge, UK. Looking forward to meeting fellow scientists and soaking in the latest research. Drop a DM if you would like to catch up during the meeting.
March 27, 2025 at 2:32 PM
I will be attending the Synuclein2025 meeting at Cambridge, UK. Looking forward to meeting fellow scientists and soaking in the latest research. Drop a DM if you would like to catch up during the meeting.
Reposted by Dr Poonam Thakur
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
February 5, 2025 at 1:53 AM
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
1/n-Excited to share the first preprint of our lab. We created a robust mouse model of #PD by combining AAV6-α-synuclein overexpression with preformed fibrils injected into the substantia nigra. This model recapitulates key features of PD, enabling mechanistic & therapeutic studies.
Key findings:
Key findings:
A Novel Mouse Model of Parkinson's Disease for Investigating Progressive Pathology and Neuroprotection https://www.biorxiv.org/content/10.1101/2025.02.13.638053v1
February 14, 2025 at 4:25 PM
1/n-Excited to share the first preprint of our lab. We created a robust mouse model of #PD by combining AAV6-α-synuclein overexpression with preformed fibrils injected into the substantia nigra. This model recapitulates key features of PD, enabling mechanistic & therapeutic studies.
Key findings:
Key findings:
Hi fellow #educators, I will be teaching a #Physiology course to UGs for the first time. I hear many students find the subject boring or difficult. Please share some good resources, videos, animations, websites or any other tips that I can use to make the course engaging & useful. #teaching
November 30, 2024 at 5:56 AM
Hi fellow #educators, I will be teaching a #Physiology course to UGs for the first time. I hear many students find the subject boring or difficult. Please share some good resources, videos, animations, websites or any other tips that I can use to make the course engaging & useful. #teaching
Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
November 9, 2024 at 5:37 PM
Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
Reposted by Dr Poonam Thakur
Hi, I’m Monica, and I’m adding people in the fields of pharmacology, physiology, and #neuroscience to the science feed!
If you’d like to be added, please respond to this post with proof that you’re in one of the fields mentioned above.
Afterward, your posts with a 🧪 emoji will show up on the feed.
If you’d like to be added, please respond to this post with proof that you’re in one of the fields mentioned above.
Afterward, your posts with a 🧪 emoji will show up on the feed.
November 8, 2024 at 2:15 AM
Hi, I’m Monica, and I’m adding people in the fields of pharmacology, physiology, and #neuroscience to the science feed!
If you’d like to be added, please respond to this post with proof that you’re in one of the fields mentioned above.
Afterward, your posts with a 🧪 emoji will show up on the feed.
If you’d like to be added, please respond to this post with proof that you’re in one of the fields mentioned above.
Afterward, your posts with a 🧪 emoji will show up on the feed.
Hello #bluesky community. I am an Assistant Professor working in the field of Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation. #HiSciSky #AcademicSky
October 18, 2023 at 4:20 PM
Hello #bluesky community. I am an Assistant Professor working in the field of Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation. #HiSciSky #AcademicSky