Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365)

👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]

Huge meta-analysis identifies many new mutations that influence #osteoarthritis in different joints. Several of the pathways involved contain proteins that are already drug targets in other diseases -> potential new osteoarthritis treatments. #GWAS www.nature.com/articles/s41...

I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:

We're recruiting!

➡️ (Senior) bioinformatician: join a collaborative project with @mhaniffa.bsky.social and Mo Lotfollahi, supporting the analysis of single-cell and spatial transcriptomics studies to train AI-based foundation models

Apply by 25 March

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.

Family-based GWAS (FGWAS) is useful to circumvent confounding affecting direct genetic effect estimates. In a recent paper, UCLA Anderson School of Management researchers do the thorough theoretical work to improve the effective sample size of and robustness of FGWAS. doi.org/10.1038/s415...

A new local genetic correlation method called HDL-L outperforms previous tools with more consistent heritability estimates and more efficient local genetic correlation estimates: nature.com/articles/s41...

One of the coolest studies I've seen, explained by @mfgrp.bsky.social in a captivating series of tweets: the body preemptively creates antibodies against commensal skin bacteria, and this system can be harnessed to create long-lasting vaccines, potentially administered just once via a topical cream!

New GWAS association method, more powerful, but not more expensive than existing methods

www.nature.com/articles/s41...

#Ketone bodies are not just about energy. Study in @cellpress.bsky.social shows metabolites are powerful signaling molecules that help clean up damaged proteins. New biology for aging and neurodegenerative disease @geriscidoc.bsky.social @sidmadhavan.bsky.social www.buckinstitute.org/news/ketone-...

Moving from X to Bluesky was really easy with Sky Follower Bridge! Can recommend if you want to find your connections from X on Bluesky. www.sky-follower-bridge.dev

Excited to see Biobank Japan has now also performed a survival GWAS! 💀 They are the first non-European Biobank to do so, as far as I'm aware. https://doi.org/10.1038/s42003-023-04491-0

Now published in @NatureAging! https://doi.org/10.1038/s43587-021-00159-8

Studying the #genetic overlap between aging traits, we identify promising protein #targets 💊

Read the full-text: https://rdcu.be/cFno2

Big thanks to @EdinUni_IGC, @NskUniversity #BiobankJapan @Finngen_FI &...

Delighted to announce our latest work on human #ageing #genes is now published in @NatureComms! https://dx.doi.org/10.1038/s41467-020-17312-3 Huge thanks to @Peterkjoshi & @Joris_Deelen for their help! We combined ageing-related GWAS and found a surprising role for haem metabolism...

Humbled to receive an award for the best flash talk at #EMGM2020! Thank you, @Peterkjoshi, and the rest of the Wilson Group for helping me practice! And thank you to the @emgm2020 organising committee for putting together such a successful conference!

Thank you to all the #EMGM2020 attendees who listened to my flash talk and asked some great questions! If you want to learn more, feel free to look at my poster...

Excited to give a flash talk about new human #ageing genes and pathways at #EMGM2020. Join me (virtually) tomorrow at 13:00 CEST in Session 1. Poster...

Impressive predictive power of polygenic risk score for coronary artery disease (and others). Top 8% of individuals three times as likely to have the disease. #Genomics #PrecisionMedicine #CAD https://www.nature.com/articles/s41588-018-0183-z