Paromita
@paroneuro.bsky.social
💭 Microbiome | Neuroscience | Host-Microbe Interactions
👩🏽🔬 Marie Sklodowska-Curie Fellow at the Elinav Lab | Head of Women in Life Science Forum
🏢 Weizmann Institute of Science | Previously: APC Microbiome | PhD: MPI Psychiatry
👩🏽🔬 Marie Sklodowska-Curie Fellow at the Elinav Lab | Head of Women in Life Science Forum
🏢 Weizmann Institute of Science | Previously: APC Microbiome | PhD: MPI Psychiatry
Reposted by Paromita
Nature research paper: Integration of hunger and hormonal state gates infant-directed aggression
go.nature.com/3WmxmvH
go.nature.com/3WmxmvH
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups.
go.nature.com
October 27, 2025 at 9:19 AM
Nature research paper: Integration of hunger and hormonal state gates infant-directed aggression
go.nature.com/3WmxmvH
go.nature.com/3WmxmvH
Reposted by Paromita
Nature research paper: Amygdala–liver signalling orchestrates glycaemic responses to stress
go.nature.com/4m2rH8t
go.nature.com/4m2rH8t
Amygdala–liver signalling orchestrates glycaemic responses to stress - Nature
Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independently of adrenal and pancreatic hormones.
go.nature.com
September 8, 2025 at 10:40 AM
Nature research paper: Amygdala–liver signalling orchestrates glycaemic responses to stress
go.nature.com/4m2rH8t
go.nature.com/4m2rH8t
Reposted by Paromita
#NeuroImmunologyPower! Woolf &co show @nature.com that peripheral neuropathy associated with type 2 #diabetes is delayed by recruitment of galactin-3 producing #macrophages which delay terminal sensory axon degeneration! #ScienceSavesLives www.nature.com/articles/s41...
Macrophages protect against sensory axon loss in peripheral neuropathy - Nature
A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
www.nature.com
February 13, 2025 at 7:35 AM
#NeuroImmunologyPower! Woolf &co show @nature.com that peripheral neuropathy associated with type 2 #diabetes is delayed by recruitment of galactin-3 producing #macrophages which delay terminal sensory axon degeneration! #ScienceSavesLives www.nature.com/articles/s41...
Reposted by Paromita
Engineered commensals for targeted nose-to-brain drug delivery. #Cell
"This study demonstrates the capability of Lp as an intranasal delivery vehicle, emphasizing its potential for brain-targeted therapeutic applications."
www.cell.com/cell/fulltex...
"This study demonstrates the capability of Lp as an intranasal delivery vehicle, emphasizing its potential for brain-targeted therapeutic applications."
www.cell.com/cell/fulltex...
February 12, 2025 at 7:31 AM
Engineered commensals for targeted nose-to-brain drug delivery. #Cell
"This study demonstrates the capability of Lp as an intranasal delivery vehicle, emphasizing its potential for brain-targeted therapeutic applications."
www.cell.com/cell/fulltex...
"This study demonstrates the capability of Lp as an intranasal delivery vehicle, emphasizing its potential for brain-targeted therapeutic applications."
www.cell.com/cell/fulltex...
Reposted by Paromita
A new #ScienceAdvances study in rats reveals neurobiological mechanisms that trigger placebo analgesia—which occurs when a pharmacologically ineffective treatment still produces pain relief. scim.ag/3CtSzxn
Opioidergic activation of the descending pain inhibitory system underlies placebo analgesia
The placebo effect can relieve pain by activating the brain’s pain inhibition system via endogenous opioidergic signals.
scim.ag
January 30, 2025 at 4:46 PM
A new #ScienceAdvances study in rats reveals neurobiological mechanisms that trigger placebo analgesia—which occurs when a pharmacologically ineffective treatment still produces pain relief. scim.ag/3CtSzxn
Reposted by Paromita
Very cool 🇨🇦-led study on liver-brain communication #multi-organ #cerebrovascular www.nature.com/articles/s41...
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity - Nature Communications
Blood vessel integrity is critical to maintain brain health. Here, the authors show that both the liver and the muscles secrete HFE2, a protein that promotes blood vessel integrity in healthy animals ...
www.nature.com
January 13, 2025 at 7:31 PM
Very cool 🇨🇦-led study on liver-brain communication #multi-organ #cerebrovascular www.nature.com/articles/s41...
Reposted by Paromita
Receiving one or two doses of HPV vaccines prior to age 17, especially for those initiating before age 15, has comparable effectiveness against high-grade cervical lesions with those who received three doses. #Lancet
Open Access
www.science.org/doi/10.1126/...
Open Access
www.science.org/doi/10.1126/...
Sexually dimorphic dopaminergic circuits determine sex preference
Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...
www.science.org
January 10, 2025 at 4:02 AM
Receiving one or two doses of HPV vaccines prior to age 17, especially for those initiating before age 15, has comparable effectiveness against high-grade cervical lesions with those who received three doses. #Lancet
Open Access
www.science.org/doi/10.1126/...
Open Access
www.science.org/doi/10.1126/...
Reposted by Paromita
The study demonstrates for the first time exactly how dopamine and serotonin work together -- or more precisely, in opposition -- to shape our learning behavior. #Nature
Read more
www.nature.com/articles/s41...
Read more
www.nature.com/articles/s41...
December 9, 2024 at 5:35 AM
The study demonstrates for the first time exactly how dopamine and serotonin work together -- or more precisely, in opposition -- to shape our learning behavior. #Nature
Read more
www.nature.com/articles/s41...
Read more
www.nature.com/articles/s41...
Reposted by Paromita
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance | Science www.science.org/doi/10.1126/...
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...
www.science.org
December 1, 2024 at 10:07 AM
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance | Science www.science.org/doi/10.1126/...
Reposted by Paromita
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
November 29, 2024 at 4:01 PM
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
Beautiful and highly mechanistic story on how differences in gut microbiota colonization in neonates modulate tolerance to viral inflammation, and thus influence the development of necrotizing enterocolitis #GutMicrbiota #Inflammation #EarlyLife #NEC
Interesting study.
Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
Microbiota and feeding modes influence the susceptibility of premature newborns to necrotizing enterocolitis (NEC) through mechanisms that remain unkn…
www.sciencedirect.com
November 29, 2024 at 9:33 AM
Beautiful and highly mechanistic story on how differences in gut microbiota colonization in neonates modulate tolerance to viral inflammation, and thus influence the development of necrotizing enterocolitis #GutMicrbiota #Inflammation #EarlyLife #NEC
Reposted by Paromita
Sex matters in #neuroinflammation
Really nice examination of genetic and hormonal sex effects in demyelination in the murine models of #Alzheimer’s disease. #neuroskyence, #neuroimmunolgy
#innateimmunity
#immunosky
Really nice examination of genetic and hormonal sex effects in demyelination in the murine models of #Alzheimer’s disease. #neuroskyence, #neuroimmunolgy
#innateimmunity
#immunosky
Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex ...
www.science.org
November 29, 2024 at 5:21 AM
Sex matters in #neuroinflammation
Really nice examination of genetic and hormonal sex effects in demyelination in the murine models of #Alzheimer’s disease. #neuroskyence, #neuroimmunolgy
#innateimmunity
#immunosky
Really nice examination of genetic and hormonal sex effects in demyelination in the murine models of #Alzheimer’s disease. #neuroskyence, #neuroimmunolgy
#innateimmunity
#immunosky
Can viruses cause food addiction? This fascinating study demonstrates that Microviridae bacteriophages can influence behavioural outcomes related to food addiction via tryptophan and tyrosine signalling pathways
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways - Nature Metabolism
Castells-Nobau et al. provide insight into how bacteriophages in the gut microbiome contribute to regulating food addiction by modulating tryptophan and tyrosine metabolism in the host.
www.nature.com
November 26, 2024 at 7:03 PM
Can viruses cause food addiction? This fascinating study demonstrates that Microviridae bacteriophages can influence behavioural outcomes related to food addiction via tryptophan and tyrosine signalling pathways
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Paromita
Mitochondrial calcium uptake declines during #aging and is directly activated by #oleuropein to boost energy metabolism and skeletal #muscle performance
www.cell.com/cell-metabol...
#sarcopenia #mitochondria #aging #nutrition
www.cell.com/cell-metabol...
#sarcopenia #mitochondria #aging #nutrition
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
Gherardi et al. identify that aging and disability impair mitochondrial calcium uptake
in skeletal muscle via MCUR1. Food-derived polyphenols increase the import of calcium
in mitochondria by binding ...
www.cell.com
November 26, 2024 at 5:34 PM
Mitochondrial calcium uptake declines during #aging and is directly activated by #oleuropein to boost energy metabolism and skeletal #muscle performance
www.cell.com/cell-metabol...
#sarcopenia #mitochondria #aging #nutrition
www.cell.com/cell-metabol...
#sarcopenia #mitochondria #aging #nutrition
Reposted by Paromita
Excited to share my first post here! Our new paper reveals a top-down breathing circuit that slows breathing to ease anxiety & fear. A step forward in understanding how brain-breathing interactions shape emotion. Published in Nature Neuroscience—grateful to my team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2024 at 7:02 PM
Excited to share my first post here! Our new paper reveals a top-down breathing circuit that slows breathing to ease anxiety & fear. A step forward in understanding how brain-breathing interactions shape emotion. Published in Nature Neuroscience—grateful to my team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...