Katrin Paeschke
@paeschkelab.bsky.social
Biochemist at the University of Bonn, interested in the molecular regulation and function of DNA and RNA structures such as G-quadruplexes and how they impact cell function and consequently human health
We are more than happy about this fantastic joint work
Our work on DNA G4 interactions with Zuo1 in collaboration with @paeschkelab.bsky.social and the Penedo lab is out in @narjournal.bsky.social 😍
Full text: academic.oup.com/nar/article/...
#G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
Full text: academic.oup.com/nar/article/...
#G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
The Zuo1 C-terminal domain stabilizes DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae
Abstract. Deoxyguanosine quadruplexes (G4s) form stable non-B-DNA structures that can affect transcription, replication, and genome stability. Depending on
academic.oup.com
November 3, 2025 at 9:02 PM
We are more than happy about this fantastic joint work
Reposted by Katrin Paeschke
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
August 25, 2025 at 2:28 PM
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
August 25, 2025 at 2:28 PM
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
August 25, 2025 at 2:26 PM
The G4 webinar series reached its XV round!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
📅We're excited to announce that it will resume on Sep 18th.
👇Take a look for all upcoming dates and don't miss out!
Summer break is over the next talks in the nucleic acid webinar will start soon. I look forward to exciting talks and discussion. Join us ☺️
August 25, 2025 at 11:01 AM
Summer break is over the next talks in the nucleic acid webinar will start soon. I look forward to exciting talks and discussion. Join us ☺️
Reposted by Katrin Paeschke
Amazing latest development in NAR demonstrating a direct role of DNA methylation for anti-viral activity. This is also in line with what recently shown by @paeschkelab.bsky.social showing that DNA G-quadruplex structure can play a role in anti-viral activity! Exciting epigenetic times ahead!
🚨 Check out the latest #Breakthrough research article published in NAR detailing how fungal plant pathogens use RNAi-mediated DNA methylation as a viral defense mechanism.
👉 Read the full article here: doi.org/10.1093/nar/...
#DNA #Methylation #Fungi #Virus
👉 Read the full article here: doi.org/10.1093/nar/...
#DNA #Methylation #Fungi #Virus
June 16, 2025 at 4:44 PM
Amazing latest development in NAR demonstrating a direct role of DNA methylation for anti-viral activity. This is also in line with what recently shown by @paeschkelab.bsky.social showing that DNA G-quadruplex structure can play a role in anti-viral activity! Exciting epigenetic times ahead!
Safe the Date - the next German French DNA repair meeting will be Nov 5-7th in Paris
Love to see many friends of the genome stability community
There:
premc.org/dnarepair2025/
#genomestability, #repair, #chembio
Love to see many friends of the genome stability community
There:
premc.org/dnarepair2025/
#genomestability, #repair, #chembio
German French DNA repair - PremC
premc.org
March 7, 2025 at 3:13 PM
Safe the Date - the next German French DNA repair meeting will be Nov 5-7th in Paris
Love to see many friends of the genome stability community
There:
premc.org/dnarepair2025/
#genomestability, #repair, #chembio
Love to see many friends of the genome stability community
There:
premc.org/dnarepair2025/
#genomestability, #repair, #chembio
Reposted by Katrin Paeschke
Predict RNA tertiary structures using NuFold
February 8, 2025 at 8:04 PM
Predict RNA tertiary structures using NuFold
Reposted by Katrin Paeschke
You are interested in Nucleic acid structures? G4s? Hope to see you at the G4 meeting next summer
g4society.org/about-g4ther...
#G4
g4society.org/about-g4ther...
#G4
December 17, 2024 at 6:00 AM
You are interested in Nucleic acid structures? G4s? Hope to see you at the G4 meeting next summer
g4society.org/about-g4ther...
#G4
g4society.org/about-g4ther...
#G4
Reposted by Katrin Paeschke
Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
January 30, 2025 at 12:21 PM
Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
If you are interested in nucleic acid structures- G4 and beyond. Here is the flyer for the next webinar series, talks range from physics to chemistry up to biology and Medicine
January 16, 2025 at 6:05 PM
If you are interested in nucleic acid structures- G4 and beyond. Here is the flyer for the next webinar series, talks range from physics to chemistry up to biology and Medicine
Reposted by Katrin Paeschke
Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
News – My WordPress
macrophagenetwork.com
December 21, 2024 at 3:02 PM
Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
Reposted by Katrin Paeschke
Only few more days left to apply! We have several #PhD #positions in the field of #immunology #development #cellbiology #macrophages! #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
January 12, 2025 at 6:02 AM
Only few more days left to apply! We have several #PhD #positions in the field of #immunology #development #cellbiology #macrophages! #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
You are interested in genome stability and on nucleic acid structures? And you would like to work in an international young team? We are looking for you- there are two open PhD in my lab open. Please contact me #biochem
#genomestability
#g4
#genomestability
#g4
December 18, 2024 at 6:37 PM
You are interested in genome stability and on nucleic acid structures? And you would like to work in an international young team? We are looking for you- there are two open PhD in my lab open. Please contact me #biochem
#genomestability
#g4
#genomestability
#g4
You are interested in Nucleic acid structures? G4s? Hope to see you at the G4 meeting next summer
g4society.org/about-g4ther...
#G4
g4society.org/about-g4ther...
#G4
December 17, 2024 at 6:00 AM
You are interested in Nucleic acid structures? G4s? Hope to see you at the G4 meeting next summer
g4society.org/about-g4ther...
#G4
g4society.org/about-g4ther...
#G4
Reposted by Katrin Paeschke
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
December 11, 2024 at 9:14 AM
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
Reposted by Katrin Paeschke
🚨 Apply now for the ImmunoSensation Postdoc Innovation Funds!
We are excited to invite early-career postdocs from the Cluster to apply for funding of up to €10,000 for a 12-month period. The funding period begins on February 1, 2025.
Application Deadline: January 10, 2025
We are excited to invite early-career postdocs from the Cluster to apply for funding of up to €10,000 for a 12-month period. The funding period begins on February 1, 2025.
Application Deadline: January 10, 2025
December 6, 2024 at 10:00 AM
🚨 Apply now for the ImmunoSensation Postdoc Innovation Funds!
We are excited to invite early-career postdocs from the Cluster to apply for funding of up to €10,000 for a 12-month period. The funding period begins on February 1, 2025.
Application Deadline: January 10, 2025
We are excited to invite early-career postdocs from the Cluster to apply for funding of up to €10,000 for a 12-month period. The funding period begins on February 1, 2025.
Application Deadline: January 10, 2025
Reposted by Katrin Paeschke
📢 New @natrevmcb.bsky.social Review!
Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research.
go.nature.com/3ZxZuhS
#NatRevMCB
Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research.
go.nature.com/3ZxZuhS
#NatRevMCB
Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology
Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...
go.nature.com
December 2, 2024 at 1:01 PM
📢 New @natrevmcb.bsky.social Review!
Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research.
go.nature.com/3ZxZuhS
#NatRevMCB
Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research.
go.nature.com/3ZxZuhS
#NatRevMCB
Reposted by Katrin Paeschke
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
December 3, 2024 at 10:33 AM
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
Reposted by Katrin Paeschke
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Katrin Paeschke
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 29, 2024 at 4:47 PM
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Reposted by Katrin Paeschke
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
November 28, 2024 at 10:31 AM
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Reposted by Katrin Paeschke
Today we celebrated the successful defense of Franz Reichel's master's thesis. Franz worked on the role of #RNA-binding proteins in #senescence as part of the @crc1678.bsky.social initiative. I could not be more proud to have such a great lab @mpiage.bsky.social
November 28, 2024 at 7:13 PM
Today we celebrated the successful defense of Franz Reichel's master's thesis. Franz worked on the role of #RNA-binding proteins in #senescence as part of the @crc1678.bsky.social initiative. I could not be more proud to have such a great lab @mpiage.bsky.social
Reposted by Katrin Paeschke
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
November 27, 2024 at 9:16 AM
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
Reposted by Katrin Paeschke
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...