Orna Issler
@ornaissler.bsky.social
Neuroscientist, feminist, mom
Assistant Professor
NYU Grossman School of Medicine
Non-coding RNAs, stress, depression, sex differences, chronic pain
www.theisslerlab.org
Assistant Professor
NYU Grossman School of Medicine
Non-coding RNAs, stress, depression, sex differences, chronic pain
www.theisslerlab.org
Reposted by Orna Issler
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Estrogen modulates reward prediction errors and reinforcement learning - Nature Neuroscience
Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.
www.nature.com
November 11, 2025 at 2:41 PM
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Reposted by Orna Issler
We’re so psyched for this - check out our amazing lineup of speakers!!! Spots are going fast - register today!!! 👇
We're excited to announce the official lineup for our in-person event! 🎉
There's one week left to sign up - registration closes Nov. 1st. You don't want to miss this!
#StoriesOfWiN #SfN #WomenInNeuroscience
There's one week left to sign up - registration closes Nov. 1st. You don't want to miss this!
#StoriesOfWiN #SfN #WomenInNeuroscience
October 27, 2025 at 5:15 PM
We’re so psyched for this - check out our amazing lineup of speakers!!! Spots are going fast - register today!!! 👇
Reposted by Orna Issler
You've probably heard how a high percentage of #Nobel laureates are immigrants. The US in particular has benefited from the influx of bright minds.
@jennaahart.bsky.social ran the data for this century's Nobel prizewinners — and shows more than 30% immigrated. 🧪
www.nature.com/articles/d41...
@jennaahart.bsky.social ran the data for this century's Nobel prizewinners — and shows more than 30% immigrated. 🧪
www.nature.com/articles/d41...
More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
www.nature.com
October 9, 2025 at 5:20 PM
You've probably heard how a high percentage of #Nobel laureates are immigrants. The US in particular has benefited from the influx of bright minds.
@jennaahart.bsky.social ran the data for this century's Nobel prizewinners — and shows more than 30% immigrated. 🧪
www.nature.com/articles/d41...
@jennaahart.bsky.social ran the data for this century's Nobel prizewinners — and shows more than 30% immigrated. 🧪
www.nature.com/articles/d41...
Yesterday was a good day:
The honor of being called a Dorothy Lambiase Derchin Scholar in Gender-Specific Medicine
A ceasefire
Optimism and relief
The honor of being called a Dorothy Lambiase Derchin Scholar in Gender-Specific Medicine
A ceasefire
Optimism and relief
October 9, 2025 at 4:45 PM
Yesterday was a good day:
The honor of being called a Dorothy Lambiase Derchin Scholar in Gender-Specific Medicine
A ceasefire
Optimism and relief
The honor of being called a Dorothy Lambiase Derchin Scholar in Gender-Specific Medicine
A ceasefire
Optimism and relief
Important negative data!
I freaking love that this team must have been like TIME TO PREPRINT
Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models
www.biorxiv.org/content/10.1...
Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models
www.biorxiv.org/content/10.1...
Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models
Acetaminophen (APAP) is the most widely used analgesic during pregnancy, yet epidemiological studies have reported conflicting associations between prenatal exposure and neurodevelopmental disorders (...
www.biorxiv.org
October 9, 2025 at 1:20 PM
Important negative data!
Reposted by Orna Issler
A new @nature.com feature on autism with real data and facts
Published today, written before the Tylenol debacle.
' Kennedy and the HHS are “going to falsely
declare the cause for autism — and that that
gets in the way of a great deal of progress”.'
www.nature.com/articles/d41...
Published today, written before the Tylenol debacle.
' Kennedy and the HHS are “going to falsely
declare the cause for autism — and that that
gets in the way of a great deal of progress”.'
www.nature.com/articles/d41...
September 25, 2025 at 2:42 PM
A new @nature.com feature on autism with real data and facts
Published today, written before the Tylenol debacle.
' Kennedy and the HHS are “going to falsely
declare the cause for autism — and that that
gets in the way of a great deal of progress”.'
www.nature.com/articles/d41...
Published today, written before the Tylenol debacle.
' Kennedy and the HHS are “going to falsely
declare the cause for autism — and that that
gets in the way of a great deal of progress”.'
www.nature.com/articles/d41...
Reposted by Orna Issler
Remember: If we allow ourselves to fall into fatalism, or wallow in disappointment, or become resigned to what is rather than what should be, we will lose the long game.
The greatest enemy of positive social change is cynicism about what can be changed.
The greatest enemy of positive social change is cynicism about what can be changed.
September 21, 2025 at 10:00 PM
Remember: If we allow ourselves to fall into fatalism, or wallow in disappointment, or become resigned to what is rather than what should be, we will lose the long game.
The greatest enemy of positive social change is cynicism about what can be changed.
The greatest enemy of positive social change is cynicism about what can be changed.
Reposted by Orna Issler
Only single cell sequencing of the all these post docs will reveal why
September 19, 2025 at 8:54 AM
Only single cell sequencing of the all these post docs will reveal why
Reposted by Orna Issler
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice - Nature Neuroscience
Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to c...
www.nature.com
August 22, 2025 at 2:52 PM
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Orna Issler
Happy to announce our new paper in Nature Communications: rdcu.be/eBpGY
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep
Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep
Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social
Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Nature Communications - Corticotropin-releasing hormone (CRH), known for activating the HPA axis during stress, also acts centrally in the brain. Here, the authors show that CRH modulates thalamic...
rdcu.be
August 20, 2025 at 7:16 AM
Happy to announce our new paper in Nature Communications: rdcu.be/eBpGY
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep
Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep
Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social
Reposted by Orna Issler
The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives.
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 13, 2025 at 2:47 PM
The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives.
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
Reposted by Orna Issler
Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early-life stress
Neuropsychopharmacology - Epigenetic regulation of brain development, plasticity, and response to early-life stress
rdcu.be
August 6, 2025 at 3:38 PM
Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
📣📣📣
Check out the new publication led by Brian Swies and his team from Mount Sinai.
It turns out that LINC00473 promotes flexible decision-making in complex cognitive tasks in females only.
Check out the new publication led by Brian Swies and his team from Mount Sinai.
It turns out that LINC00473 promotes flexible decision-making in complex cognitive tasks in females only.
New paper alert!🚨📝
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.
tinyurl.com
July 15, 2025 at 1:44 PM
📣📣📣
Check out the new publication led by Brian Swies and his team from Mount Sinai.
It turns out that LINC00473 promotes flexible decision-making in complex cognitive tasks in females only.
Check out the new publication led by Brian Swies and his team from Mount Sinai.
It turns out that LINC00473 promotes flexible decision-making in complex cognitive tasks in females only.
Reposted by Orna Issler
New paper alert!🚨📝
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.
tinyurl.com
July 15, 2025 at 1:43 AM
New paper alert!🚨📝
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8
How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Reposted by Orna Issler
From a time when childhood vaccines were just a figment of imagination.
Row after row of baby headstones.
Row after row of baby headstones.
July 14, 2025 at 12:18 AM
From a time when childhood vaccines were just a figment of imagination.
Row after row of baby headstones.
Row after row of baby headstones.
Reposted by Orna Issler
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Open Positions — Mosberger Lab
www.mosbergerlab.com
June 25, 2025 at 5:18 PM
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Reposted by Orna Issler
Now out in @elife.bsky.social as a refereed preprint:
doi.org/10.7554/eLif...
Thank you reviewers for the useful comments - we're working on them!
doi.org/10.7554/eLif...
Thank you reviewers for the useful comments - we're working on them!
June 20, 2025 at 3:20 PM
Now out in @elife.bsky.social as a refereed preprint:
doi.org/10.7554/eLif...
Thank you reviewers for the useful comments - we're working on them!
doi.org/10.7554/eLif...
Thank you reviewers for the useful comments - we're working on them!
Reposted by Orna Issler
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Orna Issler
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
June 16, 2025 at 12:19 PM
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
Reposted by Orna Issler
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
June 15, 2025 at 4:20 PM
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
Reposted by Orna Issler
If you haven't seen it yet, check out newest study from researchers @mbfneuro.bsky.social, @kristenbrennand.bsky.social, et al. in which they explore the complex functional impact of rare neurexin-1 deletions across human glutamatergic & GABAergic neurons!
In Nature www.nature.com/articles/s41...
In Nature www.nature.com/articles/s41...
June 11, 2025 at 4:18 PM
If you haven't seen it yet, check out newest study from researchers @mbfneuro.bsky.social, @kristenbrennand.bsky.social, et al. in which they explore the complex functional impact of rare neurexin-1 deletions across human glutamatergic & GABAergic neurons!
In Nature www.nature.com/articles/s41...
In Nature www.nature.com/articles/s41...
Reposted by Orna Issler
NEW STUDY from Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Silvia De Rubeis, et al. unveils sex-specific molecular signatures when Ddx3x is missing, impacting the neuronal proteome, protein synthesis machinery & nucleoli structure. Learn More @natcomms.nature.com 👉 www.nature.com/articles/s41...
June 2, 2025 at 12:00 AM
NEW STUDY from Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Silvia De Rubeis, et al. unveils sex-specific molecular signatures when Ddx3x is missing, impacting the neuronal proteome, protein synthesis machinery & nucleoli structure. Learn More @natcomms.nature.com 👉 www.nature.com/articles/s41...
Reposted by Orna Issler
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...
biorxiv.org
May 29, 2025 at 12:35 PM
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Reposted by Orna Issler
My quote of the day
We must always take sides. Neutrality helps the oppressor, never the victim. Silence encourages the tormentor, never the tormented. The opposite of love is not hate, it’s indifference.
Elie Wiesel
We must always take sides. Neutrality helps the oppressor, never the victim. Silence encourages the tormentor, never the tormented. The opposite of love is not hate, it’s indifference.
Elie Wiesel
May 27, 2025 at 10:08 AM
My quote of the day
We must always take sides. Neutrality helps the oppressor, never the victim. Silence encourages the tormentor, never the tormented. The opposite of love is not hate, it’s indifference.
Elie Wiesel
We must always take sides. Neutrality helps the oppressor, never the victim. Silence encourages the tormentor, never the tormented. The opposite of love is not hate, it’s indifference.
Elie Wiesel
Reposted by Orna Issler
The awards ceremony is one of the highlights of the Friedman Brain Institute Neuroscience Retreat. Here, @ericjnestler.bsky.social & @paulkennyphd.bsky.social present @ashleyonthebrain.bsky.social w/ the Philip Hausfeld Memorial Scholarship Award at the 17th annual retreat! A HUGE CONGRATULATIONS!💯🎉
May 22, 2025 at 7:39 PM
The awards ceremony is one of the highlights of the Friedman Brain Institute Neuroscience Retreat. Here, @ericjnestler.bsky.social & @paulkennyphd.bsky.social present @ashleyonthebrain.bsky.social w/ the Philip Hausfeld Memorial Scholarship Award at the 17th annual retreat! A HUGE CONGRATULATIONS!💯🎉