Océane Dufies
@oceanedufies.bsky.social
Postdoc in immunology @lozanzi.bsky.social at Boston Children’s Hospital
Reposted by Océane Dufies
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 6:02 PM
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Reposted by Océane Dufies
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
#ThatIsTheQuestion Post-translational modifications of NLRP3: to prime or not to prime? Thrilled to have had the opportunity to write this review with @lozanzi.bsky.social 🤩! We discuss how PTMs coordinate during priming to control NLRP3 stability, location & partners. tinyurl.com/35dy5rcc
Post-translational modifications of NLRP3: to prime or not to prime?
The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of…
tinyurl.com
November 10, 2025 at 2:24 PM
#ThatIsTheQuestion Post-translational modifications of NLRP3: to prime or not to prime? Thrilled to have had the opportunity to write this review with @lozanzi.bsky.social 🤩! We discuss how PTMs coordinate during priming to control NLRP3 stability, location & partners. tinyurl.com/35dy5rcc
Reposted by Océane Dufies
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 5:37 PM
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
Reposted by Océane Dufies
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
doi.org
October 22, 2025 at 9:40 PM
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Reposted by Océane Dufies
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Océane Dufies
💡Our webinars are back!
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
August 21, 2025 at 2:54 PM
💡Our webinars are back!
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Reposted by Océane Dufies
#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute!
Check it out! authors.elsevier.com/c/1leKGL7PXu...
Check it out! authors.elsevier.com/c/1leKGL7PXu...
authors.elsevier.com
August 21, 2025 at 3:15 PM
#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute!
Check it out! authors.elsevier.com/c/1leKGL7PXu...
Check it out! authors.elsevier.com/c/1leKGL7PXu...
Reposted by Océane Dufies
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Océane Dufies
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Oxidized phospholipid damage signals as modulators of immunity | Open Biology
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during
tissue damage that influence immune responses. Phospholipids, essential to cell membranes
and lung surfactants, ...
royalsocietypublishing.org
July 30, 2025 at 1:28 PM
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Reposted by Océane Dufies
‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1
(CASP1), which complicates interpretation of results in functional studies and limits
their clinical potenti...
www.embopress.org
July 17, 2025 at 4:41 AM
‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Océane Dufies
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Océane Dufies
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8
licenses noncanonical inflammasome activation and pyroptosis during intracellular
bacterial infections in human...
www.cell.com
July 17, 2025 at 12:12 PM
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Reposted by Océane Dufies
Are you interested in #immunometabolism but not sure where to start?
Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now.
shop.elsevier.com/books/metabo...
(1/n)
Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now.
shop.elsevier.com/books/metabo...
(1/n)
July 10, 2025 at 3:26 PM
Are you interested in #immunometabolism but not sure where to start?
Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now.
shop.elsevier.com/books/metabo...
(1/n)
Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now.
shop.elsevier.com/books/metabo...
(1/n)
Reposted by Océane Dufies
Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...
Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection | mBio
The innate immune system senses bacterial pathogens by employing pattern recognition
receptors that detect pathogen-associated molecular patterns (PAMPs) and guard proteins
that monitor pathogen disru...
journals.asm.org
June 19, 2025 at 3:40 PM
Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...
Reposted by Océane Dufies
NINJ1 regulates plasma membrane fragility under mechanical strain @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 9, 2025 at 7:08 PM
NINJ1 regulates plasma membrane fragility under mechanical strain @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Océane Dufies
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:14 PM
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Reposted by Océane Dufies
Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
nature.com
May 27, 2025 at 8:41 AM
Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
Reposted by Océane Dufies
Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
www.biorxiv.org
May 1, 2025 at 7:52 AM
Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Océane Dufies
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
March 7, 2025 at 8:49 PM
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
Reposted by Océane Dufies
One of the coolest studies of last year would not be funded by the current NIH policy. By studying people undergoing gender affirming testosterone treatment, they discovered how sex hormones shape the #immune response, with important consequences for everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
www.nature.com
March 6, 2025 at 4:12 PM
One of the coolest studies of last year would not be funded by the current NIH policy. By studying people undergoing gender affirming testosterone treatment, they discovered how sex hormones shape the #immune response, with important consequences for everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Océane Dufies
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Reposted by Océane Dufies
🚀 Call for Applications 🌍🔬
L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences.
📅 Apply by: 10 March 2025
More info: www.forwomeninscience.com/challenge/sh...
L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences.
📅 Apply by: 10 March 2025
More info: www.forwomeninscience.com/challenge/sh...
February 24, 2025 at 9:56 AM
🚀 Call for Applications 🌍🔬
L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences.
📅 Apply by: 10 March 2025
More info: www.forwomeninscience.com/challenge/sh...
L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences.
📅 Apply by: 10 March 2025
More info: www.forwomeninscience.com/challenge/sh...
Reposted by Océane Dufies
Proud to share our lab’s latest work on innate Immunity, led by Orane Visvikis Incredible work by @juangarciasanchez.bsky.social, with key contributions from Estelle Bonnet, Céline Loubatier and the whole team @univcotedazur.bsky.social @C3M @Inserm
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo
Cell biology; Functional aspects of cell biology
www.cell.com
February 23, 2025 at 8:05 AM
Proud to share our lab’s latest work on innate Immunity, led by Orane Visvikis Incredible work by @juangarciasanchez.bsky.social, with key contributions from Estelle Bonnet, Céline Loubatier and the whole team @univcotedazur.bsky.social @C3M @Inserm
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...