Nicole Knoetze 🇿🇦🇨🇦
@nknoetze.bsky.social
Bioinformatics PhD Candidate, Holt Lab | Gene Therapy | Synthetic Biology | ice hockey queen | Coffee snob (she/her)
Reposted by Nicole Knoetze 🇿🇦🇨🇦
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…
www.sciencedirect.com
August 29, 2025 at 4:49 PM
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
Reposted by Nicole Knoetze 🇿🇦🇨🇦
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
August 7, 2025 at 4:20 PM
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
Drove over 5,600km through the rockies, montana, the badlands, and more to reach our new home in Montreal. Rooi loved the adventure, and learned how to swim❤️❤️
August 6, 2025 at 11:50 AM
Drove over 5,600km through the rockies, montana, the badlands, and more to reach our new home in Montreal. Rooi loved the adventure, and learned how to swim❤️❤️
So excited to share work from my PhD! It was such a fun project and I'm so grateful that i get to work with such a great team.
Now... time for my two week drive across Canada to start my next adventure in Montreal!
Now... time for my two week drive across Canada to start my next adventure in Montreal!
Identification of Novel DNA Sequence Motifs that Modulate Transcription in T cells https://www.biorxiv.org/content/10.1101/2025.07.08.660448v1
July 12, 2025 at 3:37 AM
So excited to share work from my PhD! It was such a fun project and I'm so grateful that i get to work with such a great team.
Now... time for my two week drive across Canada to start my next adventure in Montreal!
Now... time for my two week drive across Canada to start my next adventure in Montreal!
Life update: we are selling everything we own, packing our car and moving across the country to Montreal!
So excited for the next chapter with these two.
Certainly wasn't anticipating a 10 day road trip with a puppy 😂
So excited for the next chapter with these two.
Certainly wasn't anticipating a 10 day road trip with a puppy 😂
April 13, 2025 at 5:11 PM
Life update: we are selling everything we own, packing our car and moving across the country to Montreal!
So excited for the next chapter with these two.
Certainly wasn't anticipating a 10 day road trip with a puppy 😂
So excited for the next chapter with these two.
Certainly wasn't anticipating a 10 day road trip with a puppy 😂
The best part of coming home after a week away at a conference...the snuggles 🥰
April 9, 2025 at 4:40 PM
The best part of coming home after a week away at a conference...the snuggles 🥰
Reposted by Nicole Knoetze 🇿🇦🇨🇦
One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social
March 8, 2025 at 1:18 PM
One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social
One month with Rooi. He graduated from puppy class, but you wouldn't know it 😂
February 28, 2025 at 10:42 PM
One month with Rooi. He graduated from puppy class, but you wouldn't know it 😂
This little boy has changed my world 🥰
February 10, 2025 at 3:00 AM
This little boy has changed my world 🥰
The most special week with my baby boy, Rooi. Other than the first few days adjusting, my anxiety and restlessness have been almost non-existant. Doggies are so good for us. My soul baby 🥹❤️
February 3, 2025 at 1:17 AM
The most special week with my baby boy, Rooi. Other than the first few days adjusting, my anxiety and restlessness have been almost non-existant. Doggies are so good for us. My soul baby 🥹❤️
The best week off with my little Rooi. The sweetest, spunky boy. He likes snuggles, watching hockey, and is not a fan of the rain (like his mommy) #rescuepup
January 31, 2025 at 5:20 PM
The best week off with my little Rooi. The sweetest, spunky boy. He likes snuggles, watching hockey, and is not a fan of the rain (like his mommy) #rescuepup
Welcome home little Rooi. A dream come true ❤️
January 27, 2025 at 5:55 PM
Welcome home little Rooi. A dream come true ❤️
Reposted by Nicole Knoetze 🇿🇦🇨🇦
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Conferences & Schools – 2025 – Gene Regulation – Teif Lab
generegulation.org
January 14, 2025 at 7:14 PM
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Something cute is coming.... 🥰🥰
January 19, 2025 at 2:24 AM
Something cute is coming.... 🥰🥰
Reposted by Nicole Knoetze 🇿🇦🇨🇦
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
January 15, 2025 at 5:05 PM
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Me: I want to finish my phd ASAP.
Also me: adopts a dog.
Can't wait to bring my baby home!!!!!! I am in full nesting mode.
Also me: adopts a dog.
Can't wait to bring my baby home!!!!!! I am in full nesting mode.
January 6, 2025 at 4:09 AM
Me: I want to finish my phd ASAP.
Also me: adopts a dog.
Can't wait to bring my baby home!!!!!! I am in full nesting mode.
Also me: adopts a dog.
Can't wait to bring my baby home!!!!!! I am in full nesting mode.
Had an absolute blast coaching the U11 girls ice hockey team this morning!! I never had a female coach, or any female hockey play to look up to in my entire 25 years of playing. Being able to be that for these girls was the best 🥰
January 5, 2025 at 7:04 PM
Had an absolute blast coaching the U11 girls ice hockey team this morning!! I never had a female coach, or any female hockey play to look up to in my entire 25 years of playing. Being able to be that for these girls was the best 🥰
Happy holidays! I got cozy with my two little ones 🥰🥰
December 26, 2024 at 6:36 PM
Happy holidays! I got cozy with my two little ones 🥰🥰
A weekend getaway to Whistler. The snowflakes were like mini-pancakes this weekend! The highway shut down resulted in some friends joining us. We found a box of VHS tapes and watched some very nostalgic movies...
Returned home very tired and with our Christmas tree 🥰
Returned home very tired and with our Christmas tree 🥰
December 16, 2024 at 4:44 PM
A weekend getaway to Whistler. The snowflakes were like mini-pancakes this weekend! The highway shut down resulted in some friends joining us. We found a box of VHS tapes and watched some very nostalgic movies...
Returned home very tired and with our Christmas tree 🥰
Returned home very tired and with our Christmas tree 🥰
A little bit of cuteness for the feed #dogsofbluesky
November 27, 2024 at 10:42 PM
A little bit of cuteness for the feed #dogsofbluesky
Some days I hate this tube, but not today 😊
Everything I worked on and created went into that single tube. It's a reminder of how far I've come over these past few years and the exciting things to follow.
Also my rubber ducky.
Everything I worked on and created went into that single tube. It's a reminder of how far I've come over these past few years and the exciting things to follow.
Also my rubber ducky.
November 23, 2024 at 8:38 PM
Some days I hate this tube, but not today 😊
Everything I worked on and created went into that single tube. It's a reminder of how far I've come over these past few years and the exciting things to follow.
Also my rubber ducky.
Everything I worked on and created went into that single tube. It's a reminder of how far I've come over these past few years and the exciting things to follow.
Also my rubber ducky.
A year ago today we made our way to Kruger, a 40 hour trip 🫠
We lucked out and saw every animal you would ever hope to see.We also unfortunately discovered the existence of sun spiders. Feel free to google it and immediately regret it.
I miss these days and can't wait to go back 🧡
We lucked out and saw every animal you would ever hope to see.We also unfortunately discovered the existence of sun spiders. Feel free to google it and immediately regret it.
I miss these days and can't wait to go back 🧡
November 23, 2024 at 5:31 PM
A year ago today we made our way to Kruger, a 40 hour trip 🫠
We lucked out and saw every animal you would ever hope to see.We also unfortunately discovered the existence of sun spiders. Feel free to google it and immediately regret it.
I miss these days and can't wait to go back 🧡
We lucked out and saw every animal you would ever hope to see.We also unfortunately discovered the existence of sun spiders. Feel free to google it and immediately regret it.
I miss these days and can't wait to go back 🧡
The fourth one hits home a little too hard... 🥲
November 22, 2024 at 11:02 PM
The fourth one hits home a little too hard... 🥲
Okay. I finally did it!
As much as I love science, I usually just end up posting about dogs, travel, ice hockey, and fun facts about my beer club.
A few photos of my favorite things 🥰
First beer club fact: we have rated almost 100 beers between 7 people, that's a lot of data!!!
As much as I love science, I usually just end up posting about dogs, travel, ice hockey, and fun facts about my beer club.
A few photos of my favorite things 🥰
First beer club fact: we have rated almost 100 beers between 7 people, that's a lot of data!!!
November 19, 2024 at 8:13 PM
Okay. I finally did it!
As much as I love science, I usually just end up posting about dogs, travel, ice hockey, and fun facts about my beer club.
A few photos of my favorite things 🥰
First beer club fact: we have rated almost 100 beers between 7 people, that's a lot of data!!!
As much as I love science, I usually just end up posting about dogs, travel, ice hockey, and fun facts about my beer club.
A few photos of my favorite things 🥰
First beer club fact: we have rated almost 100 beers between 7 people, that's a lot of data!!!