Nilay Taneja
@nilaytaneja.bsky.social
Postdoc @ Sloan Kettering Institute interested in all things mechanobiology during cell and tissue morphogenesis. Past: PhD @Vanderbilt
Reposted by Nilay Taneja
A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
scim.ag
May 26, 2025 at 5:04 PM
A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.
Reposted by Nilay Taneja
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...
May 16, 2025 at 8:00 AM
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...
Reposted by Nilay Taneja
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
May 12, 2025 at 2:01 PM
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Reposted by Nilay Taneja
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Link to pdf:
www.biorxiv.org/content/10.1...
Link to pdf:
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 9, 2025 at 2:37 PM
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Link to pdf:
www.biorxiv.org/content/10.1...
Link to pdf:
www.biorxiv.org/content/10.1...
Me arranging my data into a story. Spoiler alert- this cell never went past metaphase
May 9, 2025 at 3:34 PM
Me arranging my data into a story. Spoiler alert- this cell never went past metaphase
Reposted by Nilay Taneja
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 22, 2025 at 1:02 AM
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Actin obsession series 3. Dividing HeLa cell #FluorescenceFriday
May 2, 2025 at 3:56 PM
Actin obsession series 3. Dividing HeLa cell #FluorescenceFriday
Reposted by Nilay Taneja
🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors
pubs.aip.org/aip/apr/arti...
pubs.aip.org/aip/apr/arti...
April 25, 2025 at 5:21 PM
🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors
pubs.aip.org/aip/apr/arti...
pubs.aip.org/aip/apr/arti...
Actin obsession series 2. Actomyosin cortex of a blebbing M2 melanoma cell. #FluorescenceFriday
April 25, 2025 at 2:57 PM
Actin obsession series 2. Actomyosin cortex of a blebbing M2 melanoma cell. #FluorescenceFriday
Reposted by Nilay Taneja
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
April 25, 2025 at 2:08 PM
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
Actin obsession series: 1. Actin cytoskeleton in membrane ruffles at the leading edge of a crawling cancer cell
April 23, 2025 at 5:35 PM
Actin obsession series: 1. Actin cytoskeleton in membrane ruffles at the leading edge of a crawling cancer cell
Reposted by Nilay Taneja
Check out our latest study from the lab!
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
April 23, 2025 at 2:38 PM
Check out our latest study from the lab!
Reposted by Nilay Taneja
Read more about it at:
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
(PDF) Beyond mechanosensing: How cells sense and shape their physical environment during development
PDF | The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in... | Find, read and cite all the research you need on Rese...
www.researchgate.net
April 11, 2025 at 10:57 AM
Read more about it at:
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Reposted by Nilay Taneja
We are excited to share our recent preprint on how tissue spreading guides extracellular matrix changes during early morphogenesis @gurdoninstitute.bsky.social
Tissue spreading couples gastrulation through extracellular matrix remodelling in early avian embryos https://www.biorxiv.org/content/10.1101/2025.04.06.647388v1
April 10, 2025 at 8:39 AM
We are excited to share our recent preprint on how tissue spreading guides extracellular matrix changes during early morphogenesis @gurdoninstitute.bsky.social
Reposted by Nilay Taneja
Congrats to my fantastic coauthors on this work with a surprising conclusion. www.biorxiv.org/content/10.1...
Force-insensitive myosin-I enhances endocytosis robustness through actin network-scale collective ratcheting
Force production by Type-I myosins influences endocytic progression in many cell types. Since different myosin-I isoforms exhibit distinct force-dependent kinetic properties, it is important to invest...
www.biorxiv.org
April 9, 2025 at 7:09 PM
Congrats to my fantastic coauthors on this work with a surprising conclusion. www.biorxiv.org/content/10.1...
Reposted by Nilay Taneja
Ever wondered how organs take shape? Join us to find out!
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
April 10, 2025 at 9:59 AM
Ever wondered how organs take shape? Join us to find out!
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
Reposted by Nilay Taneja
I'm so pleased the final version of this research is published! We found that epithelial cells neighoring the cytokinetic furrow regulate the speed and sucess of cell division, while maintaining barrier function and cell packing geometry. Many thanks to the co-authors who contributed! 🐸 #xenopus
Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis
Xenopus epithelial cells mechanosensitively reinforce connections to neighbor cells
during cytokinesis. Here, Landino et al. show that actomyosin arrays assembled in
neighbor cells restrain cytokineti...
www.cell.com
April 10, 2025 at 12:35 PM
I'm so pleased the final version of this research is published! We found that epithelial cells neighoring the cytokinetic furrow regulate the speed and sucess of cell division, while maintaining barrier function and cell packing geometry. Many thanks to the co-authors who contributed! 🐸 #xenopus