Sparse complement C4 overexpression in a small neuronal subset triggers network-wide transcriptional remodeling—linking local immune activity to large-scale circuit changes relevant to schizophrenia and AD. Poster PSTR330.08 | Nov 18 (Tuesday), 1–5 PM Pacific, SDCC Halls B–H #SfN2025 #SanDiego
November 10, 2025 at 2:52 AM
Reposted
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex https://www.biorxiv.org/content/10.1101/2025.05.29.656749v1
May 30, 2025 at 7:15 AM
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex https://www.biorxiv.org/content/10.1101/2025.05.29.656749v1
Reposted
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex https://www.biorxiv.org/content/10.1101/2025.05.29.656749v1
May 30, 2025 at 7:15 AM
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex https://www.biorxiv.org/content/10.1101/2025.05.29.656749v1
Even subtle immune disruptions can ripple across the brain. Pathological overexpression of complement C4 in just a small subset of neurons triggers widespread gene expression changes, including cholesterol biosynthesis pathways.
🧬 doi.org/10.1101/2025... #Schizophrenia
🧬 doi.org/10.1101/2025... #Schizophrenia
Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex
The complement (C) pathway, a vital part of innate immunity, defends against pathogens and supports tissue surveillance. While local activation in the periphery enhances immune protection, dysregulati...
doi.org
May 30, 2025 at 1:39 PM
Even subtle immune disruptions can ripple across the brain. Pathological overexpression of complement C4 in just a small subset of neurons triggers widespread gene expression changes, including cholesterol biosynthesis pathways.
🧬 doi.org/10.1101/2025... #Schizophrenia
🧬 doi.org/10.1101/2025... #Schizophrenia
pmc.ncbi.nlm.nih.gov/articles/PMC... Overexpression of the schizophrenia risk gene C4 in parvalbumin-positive cells drives sex-dependent behavioral deficits and circuit dysfunction
Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction
Fast-spiking parvalbumin (PV)-positive cells are key players in orchestrating pyramidal neuron activity, and their dysfunction is consistently observed in myriad brain diseases. To understand how immu...
pmc.ncbi.nlm.nih.gov
February 6, 2025 at 4:57 AM
pmc.ncbi.nlm.nih.gov/articles/PMC... Overexpression of the schizophrenia risk gene C4 in parvalbumin-positive cells drives sex-dependent behavioral deficits and circuit dysfunction
Compelling evidence that dysregulation of the immune #complement pathway operates through neuron-specific mechanisms, resulting in synaptic loss. This has significant implications for understanding #Alzheimer's and #schizophrenia. www.nature.com/articles/s41... #glia #neuroscience #brain
The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking - Molecular Psychiatry
Molecular Psychiatry - The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking
www.nature.com
January 20, 2025 at 4:30 PM
Compelling evidence that dysregulation of the immune #complement pathway operates through neuron-specific mechanisms, resulting in synaptic loss. This has significant implications for understanding #Alzheimer's and #schizophrenia. www.nature.com/articles/s41... #glia #neuroscience #brain