Eran Mukamel
@neurome.bsky.social
Neuronal epigenomics. Dad jokes my own.
Exciting to see a package of brain development studies (mainly from mouse) from the NIH (not on bsky!?) #BRAINInitiative . Congrats to the authors, and I'm looking forward to digging into the findings/data.
www.nature.com/collections/...
www.nature.com/collections/...
BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
www.nature.com
November 7, 2025 at 7:41 PM
Exciting to see a package of brain development studies (mainly from mouse) from the NIH (not on bsky!?) #BRAINInitiative . Congrats to the authors, and I'm looking forward to digging into the findings/data.
www.nature.com/collections/...
www.nature.com/collections/...
What do you get when you cross a joke with a rhetorical question?
October 27, 2025 at 6:08 AM
What do you get when you cross a joke with a rhetorical question?
Reposted by Eran Mukamel
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
jeremymberg.github.io
October 6, 2025 at 11:28 PM
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Reposted by Eran Mukamel
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
September 1, 2025 at 10:37 PM
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
I always enjoyed visiting DC for neuroscience conferences, but now that they've sent in the storm troopers I'm sure the criminal violations of statistical best practices will finally end
August 12, 2025 at 5:40 AM
I always enjoyed visiting DC for neuroscience conferences, but now that they've sent in the storm troopers I'm sure the criminal violations of statistical best practices will finally end
Can universities go on strike by withholding licensing of all their patents by any US govt agency (incl military)? Seems like the only leverage they have and better than just giving their lunch money to the bullies
July 24, 2025 at 5:36 PM
Can universities go on strike by withholding licensing of all their patents by any US govt agency (incl military)? Seems like the only leverage they have and better than just giving their lunch money to the bullies
Interesting to see Nature retracting a study based on apparent over-clustering of single cell sequencing data
www.thetransmitter.org/cell-types/n...
www.thetransmitter.org/cell-types/n...
Nature retracts paper on novel brain cell type
A 2022 paper was retracted after an independent team of researchers reanalyzed the data and questioned its validity.
www.thetransmitter.org
July 14, 2025 at 9:25 PM
Interesting to see Nature retracting a study based on apparent over-clustering of single cell sequencing data
www.thetransmitter.org/cell-types/n...
www.thetransmitter.org/cell-types/n...
Reposted by Eran Mukamel
A reanalysis of data published in a 2024 Nature paper highlights a “thorny problem” in genetics research: how to balance curiosity and caution when searching for gene candidates.
By Katie Moisse
#neuroskyence
www.thetransmitter.org/statistics/m...
By Katie Moisse
#neuroskyence
www.thetransmitter.org/statistics/m...
Memory study sparks debate over statistical methods
The study used data filtering and statistical approaches that can yield spurious findings, but more rigorous methods can result in missed leads.
www.thetransmitter.org
July 2, 2025 at 1:43 PM
A reanalysis of data published in a 2024 Nature paper highlights a “thorny problem” in genetics research: how to balance curiosity and caution when searching for gene candidates.
By Katie Moisse
#neuroskyence
www.thetransmitter.org/statistics/m...
By Katie Moisse
#neuroskyence
www.thetransmitter.org/statistics/m...
Cool work, Marcelo et al!
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
doi.org
July 3, 2025 at 2:00 AM
Cool work, Marcelo et al!
Reposted by Eran Mukamel
I wrote a review of a recent paper on false discovery and multiple testing correction. liorpachter.wordpress.com/2025/06/16/r...
Reply to: Reply to: False positives in the study of memory-related gene expression
In the Nature paper “Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory” published on March 14th, 2024, authors Sun et al. claimed to identify cell-type specifi…
liorpachter.wordpress.com
June 16, 2025 at 9:31 PM
I wrote a review of a recent paper on false discovery and multiple testing correction. liorpachter.wordpress.com/2025/06/16/r...
Great to see attention being paid to rigor in neuroscience methods.
A statistical error known as pseudoreplication appears in more than half of recent mouse studies on neurological disorders, according to a new study. Peter Kind and Constantino Elfetheriou tell Lauren Schenkman why researchers should pay attention.
www.thetransmitter.org/pseudoreplic...
www.thetransmitter.org/pseudoreplic...
Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind
Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take…
www.thetransmitter.org
June 12, 2025 at 4:51 PM
Great to see attention being paid to rigor in neuroscience methods.
Reposted by Eran Mukamel
My statement on what's unfolding in Los Angeles.
June 8, 2025 at 11:32 PM
My statement on what's unfolding in Los Angeles.
Reposted by Eran Mukamel
Always pseudobulk, always correct for multiple comparisons, and always consult with a biostatistian. www.nature.com/articles/s41...
False positives in study of memory-related gene expression - Nature
Nature - False positives in study of memory-related gene expression
www.nature.com
June 4, 2025 at 10:06 PM
Always pseudobulk, always correct for multiple comparisons, and always consult with a biostatistian. www.nature.com/articles/s41...
Very happy to see our comment about scRNAseq methods and rigor finally published. Now more than ever, science must be an example of integrity and self-examination. If we abandon rigor, we will be even more isolated and vulnerable.
June 4, 2025 at 6:18 PM
Very happy to see our comment about scRNAseq methods and rigor finally published. Now more than ever, science must be an example of integrity and self-examination. If we abandon rigor, we will be even more isolated and vulnerable.
Hard to process the news about Harvard and international students. Other universities should stand in solidarity with our colleagues who are being persecuted.
May 23, 2025 at 4:40 AM
Hard to process the news about Harvard and international students. Other universities should stand in solidarity with our colleagues who are being persecuted.
Francis Crick speculated that DNA modifications might be key to memory.... but synaptic molecules are specific to individual neural connections
A classic test of a molecule’s importance is to block it and see what breaks. A team of researchers are using this approach to sort out why some memories stick around for a lifetime.
The Molecular Bond That Helps Secure Your Memories | Quanta Magazine
How do memories last a lifetime when the molecules that form them turn over within days, weeks or months? An interaction between two proteins points to a molecular basis for memory.
www.quantamagazine.org
May 16, 2025 at 10:02 PM
Francis Crick speculated that DNA modifications might be key to memory.... but synaptic molecules are specific to individual neural connections
Genuine question: what will all the talented US and international people who would have gone into science do instead? Real estate?
May 2, 2025 at 5:27 AM
Genuine question: what will all the talented US and international people who would have gone into science do instead? Real estate?
Reposted by Eran Mukamel
"A report by economists at American University in Washington DC estimates that a 50% reduction in federal science funding would reduce the US gross domestic product by approximately 7.6%."
Science is an amazing engine of economic activity and progress for the US ... or at least it was.
Science is an amazing engine of economic activity and progress for the US ... or at least it was.
Staff members at the US National Science Foundation (NSF) were told on 30 April to “stop awarding all funding actions until further notice,” according to an email seen by Nature.
https://go.nature.com/44Ugf9V
https://go.nature.com/44Ugf9V
Exclusive: NSF stops awarding new grants and funding existing ones
US science funder also plans to screen grant applications for compliance with ‘agency priorities’.
go.nature.com
May 1, 2025 at 11:36 PM
"A report by economists at American University in Washington DC estimates that a 50% reduction in federal science funding would reduce the US gross domestic product by approximately 7.6%."
Science is an amazing engine of economic activity and progress for the US ... or at least it was.
Science is an amazing engine of economic activity and progress for the US ... or at least it was.
First they came for the data, and I did not speak out... because I was not data
Then they came for the models, and I did not speak... because I was not a model.
Then they came for the scientists, and there was no one left to speak for me.
Then they came for the models, and I did not speak... because I was not a model.
Then they came for the scientists, and there was no one left to speak for me.
April 9, 2025 at 7:40 PM
First they came for the data, and I did not speak out... because I was not data
Then they came for the models, and I did not speak... because I was not a model.
Then they came for the scientists, and there was no one left to speak for me.
Then they came for the models, and I did not speak... because I was not a model.
Then they came for the scientists, and there was no one left to speak for me.
Science not Silence. (Kudos to the students on my hallway who put these up)
April 2, 2025 at 8:45 PM
Science not Silence. (Kudos to the students on my hallway who put these up)
I signed and urge others to sign as well.
I signed. Please consider signing.
If you are a faculty member at a US university, please consider signing this excellent petition asking our presidents, chancellors, etc to work together to defend our institutions from the direct attacks by Trump administration: sites.google.com/view/we-must...
March 31, 2025 at 5:47 AM
I signed and urge others to sign as well.
I'm ashamed of my country
February 28, 2025 at 7:15 PM
I'm ashamed of my country
So who is leading the resistance? We have no time to lose.
February 20, 2025 at 10:45 PM
So who is leading the resistance? We have no time to lose.
Spent today hearing inspiring and exciting science from fellow members of an NIH Consortium studying HIV and opioid effects on the 🧠. A reminder of what we have to lose if the US abandons our scientific enterprise.
February 11, 2025 at 6:54 AM
Spent today hearing inspiring and exciting science from fellow members of an NIH Consortium studying HIV and opioid effects on the 🧠. A reminder of what we have to lose if the US abandons our scientific enterprise.