Neelima Sharma
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neelimasharma.bsky.social
Neelima Sharma
@neelimasharma.bsky.social
160 followers 280 following 5 posts
Postdoc@Shubin Lab at UChicago.
PhD@Venkadesan Lab at Yale University.
Intrigued by the role of mechanics in the development and evolution of morphology and control.
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neelimasharma.bsky.social
Neelima Sharma @neelimasharma.bsky.social · Feb 26
Super excited to share our @plosbiology.org paper with @neilshubin.bsky.social and Yara Haridy,

“Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish”

Paper: plos.io/3CTC8La

Primer by @crumplab.bsky.social: plos.io/4kkhXa6

I hope you enjoy reading it!
Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish
Synovial joints are characterized by lubricated articular surfaces separated by a cavity, providing mobility and load-bearing, but when did they evolve? This comparative and developmental study reveal...
plos.io
Reposted by Neelima Sharma
tdcapellini.bsky.social
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
www.nature.com
August 27, 2025 at 3:13 PM
Reposted by Neelima Sharma
samjakeengland.bsky.social
Why do treehoppers look so weird?! Our latest paper, out this week in @pnas.org, suggests a perhaps unexpected reason - static electricity ⚡ We show that treehoppers can detect the electrostatic cues of predators and that their crazy shapes may boost their electrosensitivity! doi.org/10.1073/pnas...
Electroreception in treehoppers: How extreme morphologies can increase electrical sensitivity | PNAS
The link between form and function of an organism’s morphology is usually apparent or intuitive. However, some clades of organisms show remarkable ...
doi.org
July 24, 2025 at 11:44 AM
Reposted by Neelima Sharma
sermenchero.bsky.social
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...
www.cell.com
July 24, 2025 at 5:07 PM
Reposted by Neelima Sharma
seppekuehnlab.bsky.social
New paper in @nature.com! With @kiseokmicro.bsky.social , Siqi Liu, Kyle Crocker, Jojo Wang, Mikhail Tikhonov & Madhav Mani — a massive dataset and simple model reveal a few conserved regimes that capture how soil microbiome metabolism responds to perturbations. www.nature.com/articles/s41...
July 17, 2025 at 6:36 AM
Reposted by Neelima Sharma
mfabbri.bsky.social
New paper today about the evolution of the wrist along the dinosaur to bird transition: a bird-like configuration appeared in predatory dinosaurs first, as suggested by new exceptionally preserved hands of oviraptors and troodontids
www.nature.com/articles/s41...
Reorganization of the theropod wrist preceded the origin of avian flight - Nature
The forelimbs of two Late Cretaceous theropod dinosaurs show the presence of the pisiform bone, previously thought to have been lost early in theropod evolution and regained in birds during the evolut...
www.nature.com
July 9, 2025 at 3:14 PM
Reposted by Neelima Sharma
neilshubin.bsky.social
New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team!
Background and video: phys.org/news/2025-05...
Open Access Paper: www.nature.com/articles/s41...
News and Views: www.nature.com/articles/d41...
Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find
Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...
phys.org
May 21, 2025 at 3:27 PM
Reposted by Neelima Sharma
1/n 🧵 Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning
biorxiv-evobio.bsky.social bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · May 7
Learning the Shape of Evolutionary Landscapes: Geometric Deep Learning Reveals Hidden Structure in Phenotype-to-Fitness Maps https://www.biorxiv.org/content/10.1101/2025.05.07.652616v1
May 15, 2025 at 2:33 PM
neelimasharma.bsky.social
Got the opportunity to write a `behind the paper' story for @the-node.bsky.social about our work on the evolution of synovial joints, and I thoroughly enjoyed the experience.

Here it is, for some leisure reading:
May 6, 2025 at 1:55 PM
Reposted by Neelima Sharma
m-v.bsky.social
The incredible Henry Bennet-Clark passed away recently, but his wonderful science will continue to inspire.

www.stcatz.ox.ac.uk/dr-henry-ben...

He wrote numerous amazing papers, including on how fleas jump so high:

scholar.google.com/scholar?q=au...

#biomechanics #obituary #stcatz
Dr Henry Bennet-Clark (1934–2025) - St Catherine's College
Dr Henry Bennet-Clark (1934–2025) St Catherine’s College is deeply saddened to announce the passing of Dr Henry Bennet-Clark, Emeritus Reader...
www.stcatz.ox.ac.uk
March 4, 2025 at 1:07 PM
Reposted by Neelima Sharma
nakamuralab.bsky.social
Started from ontogenetic and molecular studies of living lineages, authors found reciprocally cavitated joints in placoderms. Placoderms can move pectoral fins very smoothly!! Congrats @neelimasharma.bsky.social @neilshubin.bsky.social Yara Haridy! #Teamfish #evodevo
February 27, 2025 at 10:21 PM
Reposted by Neelima Sharma
plosbiology.org
When did the lubricated joints that allow our skeleton to swivel, rotate and bend evolve? @crumplab.bsky.social explores a new @plosbiology.org paper by @neelimasharma.bsky.social &co that pinpoints their origin to the earliest jawed vertebrates 🧪 Paper: plos.io/3CTC8La Primer: plos.io/4kkhXa6
Left: A phylogeny of chordates, flanked by images of a lamprey, a placoderm, a brown shark, a longnose gar and a hawksbill turtle. Agnathans such as lampreys lack synovial joints. The first putative evidence of synovial joints in the fossil record is in early gnathostomes such as the antiarch placoderm fish that lived during the Silurian and Devonian periods. Modern gnathostomes such as cartilaginous fishes (i.e., chondrichthyans such as the brown shark), bony fishes (i.e., osteichthyans such as the longnose gar), and limbed vertebrates (i.e., tetrapods such as the Hawksbill turtle) possess synovial joints in their jaws, fins/limbs, and other locations. All images used are freely available without copyright restrictions. Top right: a typical agnathan joint is shown where glycosaminoglycans and proteoglycans are uniformly distributed across the cartilages (blue) that are connected by fibrous tissue (olive). Bottom right: a typical gnathostome synovial joint is shown where surface cartilage has a unique proteoglycan composition from the underlying cartilage and bone, and a fluid-filled cavity separates adjacent skeletal elements.
February 26, 2025 at 7:38 PM
neelimasharma.bsky.social
Super excited to share our @plosbiology.org paper with @neilshubin.bsky.social and Yara Haridy,

“Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish”

Paper: plos.io/3CTC8La

Primer by @crumplab.bsky.social: plos.io/4kkhXa6

I hope you enjoy reading it!
Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish
Synovial joints are characterized by lubricated articular surfaces separated by a cavity, providing mobility and load-bearing, but when did they evolve? This comparative and developmental study reveal...
plos.io
February 26, 2025 at 8:21 PM
Reposted by Neelima Sharma
plosbiology.org
When did synovial joints evolve? @neelimasharma.bsky.social @neilshubin.bsky.social &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones 🧪 @plosbiology.org plos.io/3CTC8La
Top: Immunostaining reveals aggrecan (yellow) at the articular surfaces in the pelvic joint of an embryonic little skate (stage 33). The nucleus is stained using DAPI and is shown in red. Bottom: Phylogenetic tree adapted from Donoghue and Keating, annotated to show that synovial joints exist in extant jawed vertebrates (gnathostomes), but the study’s results do not support their existence in cyclostomes. The presence of reciprocally shaped and cavitated joints in the dermal skeleton of antiarchs suggests that joints that function by relative sliding (similar to synovial joints) first originated in stem gnathostomes.
February 25, 2025 at 7:09 PM
Reposted by Neelima Sharma
neilshubin.bsky.social
New paper led by @neelimasharma.bsky.social on the lab! The evolutionary origin of highly mobile joints!
plosbiology.org PLOS Biology @plosbiology.org · Feb 25
When did synovial joints evolve? @neelimasharma.bsky.social @neilshubin.bsky.social &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones 🧪 @plosbiology.org plos.io/3CTC8La
Top: Immunostaining reveals aggrecan (yellow) at the articular surfaces in the pelvic joint of an embryonic little skate (stage 33). The nucleus is stained using DAPI and is shown in red. Bottom: Phylogenetic tree adapted from Donoghue and Keating, annotated to show that synovial joints exist in extant jawed vertebrates (gnathostomes), but the study’s results do not support their existence in cyclostomes. The presence of reciprocally shaped and cavitated joints in the dermal skeleton of antiarchs suggests that joints that function by relative sliding (similar to synovial joints) first originated in stem gnathostomes.
February 25, 2025 at 7:16 PM