Mateusz Konczal
@mkonczal.bsky.social
Evolutionary and population genomics
Assistant Professor in Poznan, Poland 🇵🇱
Assistant Professor in Poznan, Poland 🇵🇱
Pinned
Mateusz Konczal
@mkonczal.bsky.social
· Sep 16
Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
www.biorxiv.org
Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations. www.biorxiv.org/content/10.1...
Reposted by Mateusz Konczal
Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony https://www.biorxiv.org/content/10.1101/2025.11.04.686465v1
November 5, 2025 at 8:04 AM
Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony https://www.biorxiv.org/content/10.1101/2025.11.04.686465v1
Our latest paper with @evobiolab.bsky.social shows
sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work academic.oup.com/genetics/art...
sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work academic.oup.com/genetics/art...
Sex-specific recombination landscape in a species with holocentric chromosomes
Abstract. The rate and chromosomal positioning of meiotic recombination significantly affects the distribution of the genetic diversity in eukaryotic genom
academic.oup.com
October 20, 2025 at 8:31 AM
Our latest paper with @evobiolab.bsky.social shows
sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work academic.oup.com/genetics/art...
sex-specific recombination landscape in a species with holocentric chromosomes. Genetic map of the bulb mite, results consistent with meiotic drive hypothesis and much more. Congrats to Sebastian for tremendous work academic.oup.com/genetics/art...
Reposted by Mateusz Konczal
Including a position in my group to work on Evolutionary Genomics of Fungal pathogens
📢 EvoMG-DN PhD applications are now open!
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
October 10, 2025 at 4:00 PM
Including a position in my group to work on Evolutionary Genomics of Fungal pathogens
Reposted by Mateusz Konczal
Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…
www.sciencedirect.com
October 16, 2025 at 3:42 PM
Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mateusz Konczal
1/9 New in @science.org www.science.org/doi/10.1126/science.ado8005
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
www.science.org
October 17, 2025 at 5:50 AM
1/9 New in @science.org www.science.org/doi/10.1126/science.ado8005
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
How does genetic architecture constrain evolutionary trajectories? To address this question, we inferred the genetic architecture of convergent plumage coloration and its evolutionary history in wheatears.
Reposted by Mateusz Konczal
Anthropocene Canceled? 🚯 @ecosocialism1.bsky.social
monthlyreview.org/articles/has...
>>> Of course NOT <<<
The evidence speaks for itself.
No geologists, epochs or hype required.
theconversation.com/the-anthropo... 🌍⚒️🌐🧪
monthlyreview.org/articles/has...
>>> Of course NOT <<<
The evidence speaks for itself.
No geologists, epochs or hype required.
theconversation.com/the-anthropo... 🌍⚒️🌐🧪
October 8, 2025 at 4:54 PM
Anthropocene Canceled? 🚯 @ecosocialism1.bsky.social
monthlyreview.org/articles/has...
>>> Of course NOT <<<
The evidence speaks for itself.
No geologists, epochs or hype required.
theconversation.com/the-anthropo... 🌍⚒️🌐🧪
monthlyreview.org/articles/has...
>>> Of course NOT <<<
The evidence speaks for itself.
No geologists, epochs or hype required.
theconversation.com/the-anthropo... 🌍⚒️🌐🧪
Reposted by Mateusz Konczal
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
"Potato, potato; tomato, tomahto" but the potato evolved from the tomato 9 millions years ago 🤓
www.cell.com/news-do/pr-p...
www.cell.com/news-do/pr-p...
The potato evolved from the tomato 9 million years ago
Recent Cell research covered by The Guardian, The New York Times, The Atlantic, and more.
www.cell.com
October 8, 2025 at 8:01 AM
"Potato, potato; tomato, tomahto" but the potato evolved from the tomato 9 millions years ago 🤓
www.cell.com/news-do/pr-p...
www.cell.com/news-do/pr-p...
Reposted by Mateusz Konczal
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
September 27, 2025 at 5:03 AM
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
One of my favourite examples for #conservation #genetics classes. It reminds me that with October #TeachingIsComming
Intense ivory poaching has led to the evolution of tusklessness in some African elephant populations, which might reduce poaching, but also happens to be an X-chromosome–linked dominant trait that is lethal to males #EleFunFactFriday #TheMoreYouKnow 💫 🧪 🐘
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Ivory poaching and the rapid evolution of tusklessness in African elephants
Intensive ivory poaching during a period of civil conflict caused the rapid evolution of tusklessness in an African elephant population.
www.science.org
September 19, 2025 at 8:21 PM
One of my favourite examples for #conservation #genetics classes. It reminds me that with October #TeachingIsComming
Reposted by Mateusz Konczal
Pleased to share new work tinkering with and testing the concept of the holobiont
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities"
🌾🐭🦠
academic.oup.com/ismecommun/a...
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities"
🌾🐭🦠
academic.oup.com/ismecommun/a...
Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities
Abstract. According to the “hologenome” theory of evolution natural selection and evolution can act through a conglomerate biological unit, the “holobiont”
academic.oup.com
September 12, 2025 at 5:02 PM
Pleased to share new work tinkering with and testing the concept of the holobiont
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities"
🌾🐭🦠
academic.oup.com/ismecommun/a...
@isme-microbes.bsky.social
"Experimental evolution of a mammalian holobiont: bank voles selected for herbivorous capability evolved distinct and robust gut bacterial communities"
🌾🐭🦠
academic.oup.com/ismecommun/a...
Reposted by Mateusz Konczal
Interplay between purging and admixture shapes genetic load in an invasive guppy population https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
September 16, 2025 at 4:33 PM
Interplay between purging and admixture shapes genetic load in an invasive guppy population https://www.biorxiv.org/content/10.1101/2025.09.12.675788v1
Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations. www.biorxiv.org/content/10.1...
Interplay between purging and admixture shapes genetic load in an invasive guppy population
Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...
www.biorxiv.org
September 16, 2025 at 7:57 PM
Our latest preprint shows that in translocated invasive guppy population, genetic load is reshaped by purging and admixture. A bottleneck purged strongly deleterious mutations, but admixture reversed this effect while reducing the load of weakly deleterious mutations. www.biorxiv.org/content/10.1...
Reposted by Mateusz Konczal
How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.
Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection - Nature Ecology & Evolution
Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...
www.nature.com
September 15, 2025 at 6:17 PM
How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.
Reposted by Mateusz Konczal
Fighting to persist: Genetic rescue increases long-term fitness despite elevated genetic load https://www.biorxiv.org/content/10.1101/2025.09.06.673525v1
September 12, 2025 at 3:32 AM
Fighting to persist: Genetic rescue increases long-term fitness despite elevated genetic load https://www.biorxiv.org/content/10.1101/2025.09.06.673525v1
Check out our latest work! We experimentally showed that #genetic #rescue works: in the bulb mites, boosting genome-wide variation improved survival for 20 generations in high temp. Elevated genetic load or sexually selected traits? Barely mattered. #Conservation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 13, 2025 at 6:46 PM
Check out our latest work! We experimentally showed that #genetic #rescue works: in the bulb mites, boosting genome-wide variation improved survival for 20 generations in high temp. Elevated genetic load or sexually selected traits? Barely mattered. #Conservation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mateusz Konczal
@neelamporwal.bsky.social ‘s talk about estimating extinction risks under sexual selection using simulations, at PEC2025 won the first prize for the best student talk. So, should animals swipe right for survival?🐧
September 12, 2025 at 3:52 PM
@neelamporwal.bsky.social ‘s talk about estimating extinction risks under sexual selection using simulations, at PEC2025 won the first prize for the best student talk. So, should animals swipe right for survival?🐧
Reposted by Mateusz Konczal
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions | Nature Plants share.google/ZsqLLUu9l2Zv...
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions - Nature Plants
This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...
share.google
September 3, 2025 at 2:08 AM
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions | Nature Plants share.google/ZsqLLUu9l2Zv...
Reposted by Mateusz Konczal
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
September 3, 2025 at 8:39 AM
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Reposted by Mateusz Konczal
August 26, 2025 at 11:21 AM
Reposted by Mateusz Konczal
Fantastic dental calculus and where to find it
Johnny Richards and team (@markella-morait.bsky.social + curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation. #aDNA #museomics
www.biorxiv.org/content/10.1...
Johnny Richards and team (@markella-morait.bsky.social + curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation. #aDNA #museomics
www.biorxiv.org/content/10.1...
August 26, 2025 at 9:13 AM
Fantastic dental calculus and where to find it
Johnny Richards and team (@markella-morait.bsky.social + curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation. #aDNA #museomics
www.biorxiv.org/content/10.1...
Johnny Richards and team (@markella-morait.bsky.social + curators from 5 museums) survey >140 mammalian species with >1,600 specimens to understand what factors determine dental calculus formation. #aDNA #museomics
www.biorxiv.org/content/10.1...
Reposted by Mateusz Konczal
If you are frustrated with the quality of reviews and excessive article processing charges, take a minute read:
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
A simple recipe for a truly open, prestigious, society-owned journal
Is there anything wrong with the current model of scientific publishing, and, if so, can we, practising researchers, do anything about it? I...
trulyopenscience.blogspot.com
July 28, 2025 at 7:18 PM
If you are frustrated with the quality of reviews and excessive article processing charges, take a minute read:
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
trulyopenscience.blogspot.com/2025/07/a-si...
We researchers really have a power to change this!
#ScientificPublishing
Reposted by Mateusz Konczal
With #eseb2025 coming to a close, it is time to start making plans for 2026. Interested in the interface of evolution 🧬 and ecology 🌳? Come to our #ExE conference hosted by @uniexecec.bsky.social in beautiful #Cornwall. Leave your email address at tinyurl.com/EvolxEcol to join our mailing list!
August 22, 2025 at 1:32 PM
With #eseb2025 coming to a close, it is time to start making plans for 2026. Interested in the interface of evolution 🧬 and ecology 🌳? Come to our #ExE conference hosted by @uniexecec.bsky.social in beautiful #Cornwall. Leave your email address at tinyurl.com/EvolxEcol to join our mailing list!
Small update:
Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide #eseb2025
Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide #eseb2025
#eseb2025 talks were great so far. Subjective ranking of the most common quotes:
- theory and modeling: "with this very simple approach"
- genomics: "using methodology you all know"
- plenaries: "Nature/Science" in the bottom right of a slide
- posters: "una cerveza por favor"
- theory and modeling: "with this very simple approach"
- genomics: "using methodology you all know"
- plenaries: "Nature/Science" in the bottom right of a slide
- posters: "una cerveza por favor"
August 22, 2025 at 8:52 AM
Small update:
Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide #eseb2025
Plenaries and Nosil talks: "Nature/Science" in the bottom right of a slide #eseb2025
Reposted by Mateusz Konczal
We are having fantastic time presenting and discussing our work at #ESEB2025
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"
August 21, 2025 at 6:08 PM
We are having fantastic time presenting and discussing our work at #ESEB2025
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"
- Neelam Porwal answered a question "How sexual selection shapes small populations demography under recurrent heatwaves"