mj1997.bsky.social
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mj1997.bsky.social
@mj1997.bsky.social
200 followers 42 following 1.6K posts
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sailorrooscout.bsky.social
Pancreatic cancer is one of the most aggressive tumors with the worst prognosis, partly because of the rapid emergence of resistance to treatment. But a new study from the Spanish National Cancer Research Centre (CNIO), led by Dr. Mariano Barbacid, reveals that it is possible to eliminate pancreatic
January 29, 2026 at 5:05 PM
Reposted by mj1997.bsky.social
sailorrooscout.bsky.social
Researchers managed to overcome tumors using a triple combination therapy, which also avoids the common problem of treatment resistance. Currently, drugs for pancreatic cancer lose effectiveness within months because the tumour becomes resistant.
• www.timesnownews.com/world/who-is...
Who Is Dr. Mariano Barbacid? Spanish Scientist Leading The Most Promising Pancreatic Cancer Breakthrough Yet
Dr. Mariano Barbacid, a pioneering Spanish cancer scientist, alongside his team have eliminated aggressive pancreatic tumours in mice using a triple-drug therapy targeting the KRAS pathway. While not ...
www.timesnownews.com
January 29, 2026 at 5:05 PM
Reposted by mj1997.bsky.social
sailorrooscout.bsky.social
The study has been published in PNAS (Proceedings of the National Academy of Sciences). YES, it is PEER-REVIEWED.
• www.pnas.org/doi/10.1073/...

NOTE: THIS IS PRECLINICAL. Results were also shown in tumors taken from HUMAN patients and grown in the laboratory.

🧪🧵⬇️
Significance The development of RAS inhibitors represents a major advance in the treatment of KRAS-driven pancreatic ductal adenocarcinoma (PDAC). RAS(ON) inhibitors such as daraxonrasib (RMC-6236) have led to significant improvements in survival compared to historical data. Unfortunately, the rapid onset of tumor resistance has thwarted their therapeutic benefit. This study describes a triple combination therapy made of daraxonrasib along with afatinib, an irreversible EGFR/ HER2 kinase inhibitor and SD36, a selective STAT3 PROTAC that induces the robust regression of experimental PDACs and avoids the onset of tumor resistance. This triple combination is well tolerated in mice. Taken together, these studies open the road to design novel combination therapies that may improve the survival of PDAC patients. Abstract Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies, although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, we demonstrate that genetic ablation of three independent nodes involved in downstream (RAF1), upstream (EGFR), and orthogonal (STAT3) KRAS signaling pathways leads to complete and permanent regression of orthotopic PDACs induced by KRAS/TP53 mutations. Likewise, a combination of selective inhibitors of KRAS (RMC-6236/daraxonrasib), EGFR family (afatinib), and STAT3 (SD36) induced the complete regression of orthotopic PDAC tumors with no evidence of tumor resistance for over 200 d posttreatment. This combination therapy also led to significant regression of genetically engineered mouse tumors as well as patient-derived tumor xenografts (PDX) in the absence of tumor relapses. Of importance, this combination therapy was well tolerated. In sum, these results should guide the development of new clinical trials that may benefit PDAC patients.
January 29, 2026 at 5:04 PM
Reposted by mj1997.bsky.social
sailorrooscout.bsky.social
GOOD NEWS! For the FIRST time ever, researchers have developed a targeted combination therapy that has successfully AND completely ELIMINATED KRAS-driven pancreatic tumors in experimental models. Tumors regressed COMPLETELY with NO recurrence OR major side effects. Let’s talk about that!
January 29, 2026 at 5:00 PM
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salivahero.bsky.social
something quick for 🐸🐶
January 29, 2026 at 12:27 PM
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dendenart.eu
CLOSED!!

Thank you so much everyone for sharing and for your interest!

I have already contacted some of the people who submitted an entry and will continue with the rest throughout the day. 👏
dendenart.eu 🌆 DenDen 🌆 🔜 ❄️ NFC ❄️ @dendenart.eu · 1d
💘 Commission slots for February are OPEN! 💘

💕 Submission form: artda.sh/o/486c2fb6-5...

💕 Prices and ToS: dendenart.eu

Shares are super appreciated!!

#furry #furryart #commsopen
January 29, 2026 at 12:36 PM
Reposted by mj1997.bsky.social
purplebirdman.com
he becomes a baker and family man eventually btw
January 29, 2026 at 2:23 PM
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frescogray.bsky.social
Snuggle Trap!
*
Artist: @artsyclaws.bsky.social
Editor: @frescogray.bsky.social
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Tags: #furries #furry #furryfandom #furrycommunity #animation #fyp
January 29, 2026 at 12:43 AM
Reposted by mj1997.bsky.social
mellonbun.bsky.social
Since I have to urgently move out in the next two weeks, I'm opening commissions until end of February. The forms are open for submissions, but DMs are open too! For any questions feel free to ask me! 💕🌞
forms.gle/6U5xLQo7g8zY...
January 29, 2026 at 3:06 PM
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artsyclaws.bsky.social
Strawberry Date 🍓🩷✨ (art trade for Moss!)
January 29, 2026 at 3:08 PM
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purplebirdman.com
goats out having a good time! ft sublamy
January 29, 2026 at 2:56 PM
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mellonbun.bsky.social
Forgot to post this 💗🍒
January 28, 2026 at 10:01 PM
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clairebearart.bsky.social
Art for @boltrailwaydog.bsky.social

　　.o　O　　0　　　O
　┌┐____
　_| |_|□　| ┌════┐
(　=\ |══|=▏□　　□▕
/_⊙⊙═◎◎╙....⊙⊙═⊙⊙┘ . . . .
January 29, 2026 at 3:00 AM
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dendenart.eu
And make more designs in general;
my passion for creating merch is returning and im SOOOO here for it!!
January 29, 2026 at 7:28 AM
Reposted by mj1997.bsky.social
dendenart.eu
When at DDs do you guys like buying prints?
And if yes what size do you usually go for?

Im super excited for the new printer ill be getting after NFC where id be able to print up to A3 (11.7 x 16.5in) and im gauging interest qvq

Theres quite a few pieces in mind id LOVE to make into prints!
January 29, 2026 at 7:28 AM
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cydoniaxia.bsky.social
January 28, 2026 at 8:59 PM
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rsswolf.bsky.social
January 28, 2026 at 9:04 PM
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rotfox.tv
Your fox wants nachos

I'm your fox
January 28, 2026 at 9:22 PM
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mellonbun.bsky.social
(almost) Artist reveal? 💗👉👈
January 28, 2026 at 7:57 PM
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artsyclaws.bsky.social
He'd Been A Very Good Boy 🦊🩷
January 28, 2026 at 5:44 PM
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mellonbun.bsky.social
I love drawing sheer clothes so much aaa
January 28, 2026 at 5:57 PM
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magiczapdragon.bsky.social
plushy dragon has spawned!!💕
another quick creature for groshie money :3

they’re up on kofi if you luv them!!

ko-fi.com/s/7a29b7ebb4

#furry #furryart #plush #plushy #dragon #adopt #adoptable
a digital doodle of a cute pink and purple plushy dragon holding a really big sewing needle
January 28, 2026 at 6:45 PM
Reposted by mj1997.bsky.social
dendenart.eu
💘 Commission slots for February are OPEN! 💘

💕 Submission form: artda.sh/o/486c2fb6-5...

💕 Prices and ToS: dendenart.eu

Shares are super appreciated!!

#furry #furryart #commsopen
January 28, 2026 at 3:54 PM
Reposted by mj1997.bsky.social
skip4d.art
couple of dogs headed to the @vrchat.com marketplace soon, they're on the chibi but rebuilt from the ground up!

If they sell well I'm happy to make a whole bunch of em in all sorts of species ^_^
oh also, there are like a billion customization options

pc/quest/arkit ft

#3dart #vrc #furry #b3d
January 27, 2026 at 9:25 PM