Michael Bogdos
@mixalhsmpogdos.bsky.social
Chemist (postdoc @ Princeton, PhD @ ETHZ, MSc @ Uni Strathclyde)
Reposted by Michael Bogdos
When researchers bring up confounders without ever having declared the actual analysis goal
October 28, 2025 at 10:24 AM
When researchers bring up confounders without ever having declared the actual analysis goal
Reposted by Michael Bogdos
Congrats to Emilien, Maurus and Giorgia! Metal- and CO-Free Carbonylation of Alkyl Iodides @jacs.acspublications.org pubs.acs.org/doi/abs/10.1...
October 17, 2025 at 5:09 PM
Congrats to Emilien, Maurus and Giorgia! Metal- and CO-Free Carbonylation of Alkyl Iodides @jacs.acspublications.org pubs.acs.org/doi/abs/10.1...
Reposted by Michael Bogdos
Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...
An Inverse Electron-Demand Diels–Alder Approach to Selective Activity-Based Sensing of Acetaldehyde in Living Cells
Acetaldehyde (AA) is a reactive aldehyde primarily produced in cells as a metabolic intermediate during ethanol oxidation. Excess AA, often resulting from impaired AA detoxification, leads to aberrant...
pubs.acs.org
October 16, 2025 at 7:22 PM
Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...
Reposted by Michael Bogdos
Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Nathalie, Patrick, Fabio and Jan on this epic study of C-N red. elim. in @jacs.acspublications.org - using causal inference, organometallics, electrochemistry, kinetics and DFT. pubs.acs.org/doi/full/10....
October 14, 2025 at 9:50 AM
Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Nathalie, Patrick, Fabio and Jan on this epic study of C-N red. elim. in @jacs.acspublications.org - using causal inference, organometallics, electrochemistry, kinetics and DFT. pubs.acs.org/doi/full/10....
Great to see this published!
In short, we introduced causal inference logic to test which of metal electronics, ancillary ligand sterics and metal coordination number (CN) directly affect the rate of reductive elimination at Pd(II) (and presumably other metals...)
1/
In short, we introduced causal inference logic to test which of metal electronics, ancillary ligand sterics and metal coordination number (CN) directly affect the rate of reductive elimination at Pd(II) (and presumably other metals...)
1/
Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Nathalie, Patrick, Fabio and Jan on this epic study of C-N red. elim. in @jacs.acspublications.org - using causal inference, organometallics, electrochemistry, kinetics and DFT. pubs.acs.org/doi/full/10....
October 14, 2025 at 6:15 PM
Great to see this published!
In short, we introduced causal inference logic to test which of metal electronics, ancillary ligand sterics and metal coordination number (CN) directly affect the rate of reductive elimination at Pd(II) (and presumably other metals...)
1/
In short, we introduced causal inference logic to test which of metal electronics, ancillary ligand sterics and metal coordination number (CN) directly affect the rate of reductive elimination at Pd(II) (and presumably other metals...)
1/
Pleased to have been awarded the ETH Medal this summer for my PhD thesis!
Many thanks to all those who supported me through my journey, especially my PhD supervisor Prof. Bill Morandi.
Many thanks to all those who supported me through my journey, especially my PhD supervisor Prof. Bill Morandi.
September 13, 2025 at 10:40 PM
Pleased to have been awarded the ETH Medal this summer for my PhD thesis!
Many thanks to all those who supported me through my journey, especially my PhD supervisor Prof. Bill Morandi.
Many thanks to all those who supported me through my journey, especially my PhD supervisor Prof. Bill Morandi.
Reposted by Michael Bogdos
Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...
September 2, 2025 at 7:18 PM
Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...
Reposted by Michael Bogdos
We have two open PhD positions to start our new group at University of Geneva!
If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here:
jobs.unige.ch/www/wd_porta...
If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here:
jobs.unige.ch/www/wd_porta...
Assistant-e (A2) postes de doctorat en chimie inorganique / organométallique (6378)
jobs.unige.ch
May 11, 2025 at 9:17 AM
We have two open PhD positions to start our new group at University of Geneva!
If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here:
jobs.unige.ch/www/wd_porta...
If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here:
jobs.unige.ch/www/wd_porta...
Reposted by Michael Bogdos
Blunt letter to the editor on ACS: "If ACS won’t stand up now, it should stand down." cen.acs.org/business/Rea... #chemsky 🧪⚗️
April 25, 2025 at 12:13 AM
Blunt letter to the editor on ACS: "If ACS won’t stand up now, it should stand down." cen.acs.org/business/Rea... #chemsky 🧪⚗️
100 %.
Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism?
That is to say nothing of the intra EU inequality, a whole other can of worms.
Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism?
That is to say nothing of the intra EU inequality, a whole other can of worms.
American scientists aren't special. It's the institutions, and willingness to spend on research, that set them apart. Similarly invest here, and you will naturally attract the best talent from *everywhere*.
www.politico.eu/article/euro...
www.politico.eu/article/euro...
Europe to burned American scientists: We’ll take you in
The EU’s body for scientific research, as well as local, regional and national governments, are mobilizing to poach top U.S. scholars.
www.politico.eu
April 6, 2025 at 7:26 PM
100 %.
Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism?
That is to say nothing of the intra EU inequality, a whole other can of worms.
Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism?
That is to say nothing of the intra EU inequality, a whole other can of worms.
Reposted by Michael Bogdos
Re-upping this post this morning: Big Pharma CEOs are finally starting to speak out about the Trump administration.
Unfortunately, they’re smiling and clapping.
Unfortunately, they’re smiling and clapping.
Pharma CEOS Speaking Up, Damn It
www.science.org
February 20, 2025 at 2:34 PM
Re-upping this post this morning: Big Pharma CEOs are finally starting to speak out about the Trump administration.
Unfortunately, they’re smiling and clapping.
Unfortunately, they’re smiling and clapping.
Reposted by Michael Bogdos
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 4:45 PM
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Reposted by Michael Bogdos
When the federal government abandons important areas of funding and leaves a gaping hole in the advancement of science, any prudent funder would fill the hole, not follow suit. I don’t know the rationale here but seriously WTF?
Disclosure: HHMI paid my way through graduate school.
Disclosure: HHMI paid my way through graduate school.
The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US
HHMI kills program aimed at boosting inclusivity in STEM education
“Inclusive excellence” program had committed $60 million to 104 institutions
scim.ag
February 7, 2025 at 7:48 AM
When the federal government abandons important areas of funding and leaves a gaping hole in the advancement of science, any prudent funder would fill the hole, not follow suit. I don’t know the rationale here but seriously WTF?
Disclosure: HHMI paid my way through graduate school.
Disclosure: HHMI paid my way through graduate school.
Reposted by Michael Bogdos
Hey American PIs. If you have undergrad students who, for whatever personal reasons might find it...appropriate to not do grad school in the good ol' US of A for the next 4+ years, I (and my colleagues at UWindsor Chem) are open to applicants. They pay Canadian domestic rates at UWindsor.
January 27, 2025 at 5:29 AM
Hey American PIs. If you have undergrad students who, for whatever personal reasons might find it...appropriate to not do grad school in the good ol' US of A for the next 4+ years, I (and my colleagues at UWindsor Chem) are open to applicants. They pay Canadian domestic rates at UWindsor.
Reposted by Michael Bogdos
And you WON'T BELIEVE the incentives the Canadian Government will give you to just do R&D in Canada. It's literally insane. Anyways, happy to talk and connect people if anyone is interested. Things might get rocky for a bit, and staff might be happier living somewhere that thinks they are humans.
January 27, 2025 at 5:33 AM
And you WON'T BELIEVE the incentives the Canadian Government will give you to just do R&D in Canada. It's literally insane. Anyways, happy to talk and connect people if anyone is interested. Things might get rocky for a bit, and staff might be happier living somewhere that thinks they are humans.
How does one include all sources of error for a quantity of interest obtained by fitting a model e.g. rate constants from kinetics?
Simulations give the answer:
atigdnc.netlify.app/post/error_handling/
tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky
Simulations give the answer:
atigdnc.netlify.app/post/error_handling/
tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky
January 11, 2025 at 6:05 PM
How does one include all sources of error for a quantity of interest obtained by fitting a model e.g. rate constants from kinetics?
Simulations give the answer:
atigdnc.netlify.app/post/error_handling/
tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky
Simulations give the answer:
atigdnc.netlify.app/post/error_handling/
tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky
Wrapping up 2024 - quite the year! I defended my PhD, after more than 4 years at ETH.
Here's hoping 2025 has something just as exciting in store!
Here's hoping 2025 has something just as exciting in store!
December 22, 2024 at 11:29 PM
Wrapping up 2024 - quite the year! I defended my PhD, after more than 4 years at ETH.
Here's hoping 2025 has something just as exciting in store!
Here's hoping 2025 has something just as exciting in store!
Along similar lines, the results of the second protein binder design competition were announced and de novo design didn't do so well:
www.adaptyvbio.com/blog/po103
www.adaptyvbio.com/blog/po103
December 8, 2024 at 10:55 AM
Along similar lines, the results of the second protein binder design competition were announced and de novo design didn't do so well:
www.adaptyvbio.com/blog/po103
www.adaptyvbio.com/blog/po103
I think that just like with protein prediction, the community should now only look at the results of competitions (à la CASP).
The docking equivalent is:
cache-challenge.org
www.nature.com/articles/s41...
The docking equivalent is:
cache-challenge.org
www.nature.com/articles/s41...
December 7, 2024 at 10:21 PM
I think that just like with protein prediction, the community should now only look at the results of competitions (à la CASP).
The docking equivalent is:
cache-challenge.org
www.nature.com/articles/s41...
The docking equivalent is:
cache-challenge.org
www.nature.com/articles/s41...
New radical cross-coupling using phosphonium salts and HMDS anion as the electron donor:
www.nature.com/articles/s41...
I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.
www.nature.com/articles/s41...
I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.
Coupling of unactivated alkyl electrophiles using frustrated ion pairs - Nature
A transition-metal-free platform enables the formation of challenging C(sp3)–C(sp3) bonds in organic compounds via single-electron transfer, facilitating the coupling of functionalized fragments and e...
www.nature.com
November 23, 2024 at 9:02 AM
New radical cross-coupling using phosphonium salts and HMDS anion as the electron donor:
www.nature.com/articles/s41...
I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.
www.nature.com/articles/s41...
I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.
Reposted by Michael Bogdos
For trans day of remembrance, this is Ben Barres.
Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.
Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.
November 20, 2024 at 7:42 AM
For trans day of remembrance, this is Ben Barres.
Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.
Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.
My first FA of my PhD investigated the factors controlling the β-Η/β-Χ competition in Pd(II) alkyls:
rdcu.be/cVqUz
The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research).
#chemsky
rdcu.be/cVqUz
The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research).
#chemsky
November 20, 2024 at 10:47 AM
My first FA of my PhD investigated the factors controlling the β-Η/β-Χ competition in Pd(II) alkyls:
rdcu.be/cVqUz
The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research).
#chemsky
rdcu.be/cVqUz
The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research).
#chemsky
Reposted by Michael Bogdos
An amazing thing to say. Whoever it was has a greatly inflated idea of what the Big Labs are able to think of and to cover.
And big-lab-group-think is a stifling influence. Last month I gave a talk at a local big pharma site and the director/host literally asked me “if [insert three big names of field] haven’t already thought of the idea you presented, how could it possibly be true/important?”
November 19, 2024 at 1:47 PM
An amazing thing to say. Whoever it was has a greatly inflated idea of what the Big Labs are able to think of and to cover.
A tool for predicting glycosylation based on structure:
www.nature.com/articles/s41...
Hopefully this is broadly generalizable, it would be invaluable.
www.nature.com/articles/s41...
Hopefully this is broadly generalizable, it would be invaluable.
Restoring protein glycosylation with GlycoShape - Nature Methods
GlycoShape is an open-access web-based platform designed to supplement three-dimensional glycoprotein structures with missing structural information on glycans. To link them, the Re-Glyco algorithm ev...
www.nature.com
November 19, 2024 at 10:18 AM
A tool for predicting glycosylation based on structure:
www.nature.com/articles/s41...
Hopefully this is broadly generalizable, it would be invaluable.
www.nature.com/articles/s41...
Hopefully this is broadly generalizable, it would be invaluable.
