Pinned
JCI -
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
www.jci.org
Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...
Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...
JCI -
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
www.jci.org
November 10, 2025 at 5:57 PM
Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...
Reposted by Mindy Kim Graham
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
I’m excited to share my first corresponding author publication in
@jclinical-invest.bsky.social! Leveraging an incredible scRNA-seq dataset from Kfoury et al. (Cancer Cell, 2021), we asked: what changes happen in the bone marrow before overt prostate cancer metastasis? doi.org/10.1172/JCI1...
@jclinical-invest.bsky.social! Leveraging an incredible scRNA-seq dataset from Kfoury et al. (Cancer Cell, 2021), we asked: what changes happen in the bone marrow before overt prostate cancer metastasis? doi.org/10.1172/JCI1...
JCI -
Prostate tumor-mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL10 signaling
doi.org
August 29, 2025 at 1:14 PM
I’m excited to share my first corresponding author publication in
@jclinical-invest.bsky.social! Leveraging an incredible scRNA-seq dataset from Kfoury et al. (Cancer Cell, 2021), we asked: what changes happen in the bone marrow before overt prostate cancer metastasis? doi.org/10.1172/JCI1...
@jclinical-invest.bsky.social! Leveraging an incredible scRNA-seq dataset from Kfoury et al. (Cancer Cell, 2021), we asked: what changes happen in the bone marrow before overt prostate cancer metastasis? doi.org/10.1172/JCI1...
Reposted by Mindy Kim Graham
We’re pleased to share our new bioRxiv study:
Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor.
Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME.
www.biorxiv.org/content/10.1...
#miRNA #ProstateCancer #scRNAseq
Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor.
Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME.
www.biorxiv.org/content/10.1...
#miRNA #ProstateCancer #scRNAseq
Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer
Aberrant microRNA expression is common in cancer, yet cell-type-specific microRNA activity in the tumor microenvironment (TME) remains poorly understood. Here, we show that germline deletion of miR-21...
www.biorxiv.org
May 19, 2025 at 1:35 PM
We’re pleased to share our new bioRxiv study:
Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor.
Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME.
www.biorxiv.org/content/10.1...
#miRNA #ProstateCancer #scRNAseq
Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor.
Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME.
www.biorxiv.org/content/10.1...
#miRNA #ProstateCancer #scRNAseq
Reposted by Mindy Kim Graham
chatomics! Scanpy and Seurat marker gene log2Fold change has a big discrepancy!
Do you understand log2Fold change in single-cell RNAseq data? divingintogeneticsandgenomics.com/post/do-you...
Do you understand log2Fold change in single-cell RNAseq data? divingintogeneticsandgenomics.com/post/do-you...
December 7, 2024 at 2:15 PM
chatomics! Scanpy and Seurat marker gene log2Fold change has a big discrepancy!
Do you understand log2Fold change in single-cell RNAseq data? divingintogeneticsandgenomics.com/post/do-you...
Do you understand log2Fold change in single-cell RNAseq data? divingintogeneticsandgenomics.com/post/do-you...
Reposted by Mindy Kim Graham
Interested in recording cell dynamics? Beautiful review from colleagues around Tanja Stadler and Martin Tran @NatureRevGenet on DNA recording in single cells and lienages. With lots of exciting opportunities for single cell modeling. nature.com/articles/s41576-024-00788-w
December 3, 2024 at 9:30 AM
Interested in recording cell dynamics? Beautiful review from colleagues around Tanja Stadler and Martin Tran @NatureRevGenet on DNA recording in single cells and lienages. With lots of exciting opportunities for single cell modeling. nature.com/articles/s41576-024-00788-w