Maria Mihaylova
@mihaylova.bsky.social
Assistant Professor at the Ohio State University and OSU Comprehensive Cancer Center | Metabolism, Cancer and Aging | views are my own
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
September 23, 2025 at 12:55 PM
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
Reposted by Maria Mihaylova
excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!
Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production https://www.biorxiv.org/content/10.1101/2025.02.07.637120v1
February 10, 2025 at 6:40 PM
excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!
Reposted by Maria Mihaylova
Good Sunday, all. What a wonderful collection of papers in #cancermetabolism and #mitochondrialbiology this is! Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social
Happy holiday season to you all!
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
Happy holiday season to you all!
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
bart simpson is talking to santa claus who is laying in a chair
ALT: bart simpson is talking to santa claus who is laying in a chair
media.tenor.com
December 22, 2024 at 6:37 AM
Good Sunday, all. What a wonderful collection of papers in #cancermetabolism and #mitochondrialbiology this is! Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social
Happy holiday season to you all!
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
Happy holiday season to you all!
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
Reposted by Maria Mihaylova
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Reposted by Maria Mihaylova
Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging
Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...
www.nature.com
November 27, 2024 at 2:42 PM
Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk