Antony Rod. Lab
@micrornax.bsky.social
Molecular biologist and Professor @BCM working on miRNAs, lung epithelial stem cells, IPF, COPD.
Reposted by Antony Rod. Lab
💸 Stem cell culture that’s ~95% cheaper and weekend-free: a win-win for PIs and trainees!
Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1...
Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!
Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1...
Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!
open-research-europe.ec.europa.eu
September 20, 2025 at 2:41 PM
💸 Stem cell culture that’s ~95% cheaper and weekend-free: a win-win for PIs and trainees!
Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1...
Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!
Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1...
Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!
Reposted by Antony Rod. Lab
Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.
September 7, 2025 at 9:50 PM
Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.
Reposted by Antony Rod. Lab
CDS? ORF? Here is a new nomenclature for the translated regions of mRNAs: TRANSLON.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Translon: a single term for translated regions - Nature Methods
Nature Methods - Translon: a single term for translated regions
www.nature.com
September 2, 2025 at 1:44 PM
CDS? ORF? Here is a new nomenclature for the translated regions of mRNAs: TRANSLON.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Antony Rod. Lab
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
July 26, 2025 at 7:15 PM
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
Reposted by Antony Rod. Lab
🚀 New from Cell: SPIDR is a game-changer—map dozens to hundreds of RNA-binding proteins simultaneously with single-nucleotide precision in one CLIP experiment. An exciting advance for RNA–protein interactomics! 🧬🔗https://doi.org/10.1016/j.cell.2025.06.042
July 27, 2025 at 8:02 AM
🚀 New from Cell: SPIDR is a game-changer—map dozens to hundreds of RNA-binding proteins simultaneously with single-nucleotide precision in one CLIP experiment. An exciting advance for RNA–protein interactomics! 🧬🔗https://doi.org/10.1016/j.cell.2025.06.042
Reposted by Antony Rod. Lab
I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
July 3, 2025 at 1:10 PM
I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
Reposted by Antony Rod. Lab
Our recent article on transposable elements and aging - which made the June cover - is the focus of a new Highlight.
"Highlight: 'Jumping Genes' Caught in an Aging Merry-Go-Round"
🔗 doi.org/10.1093/gbe/evaf094
🖌️ Miriam Merenciano
#genome #TEsky
"Highlight: 'Jumping Genes' Caught in an Aging Merry-Go-Round"
🔗 doi.org/10.1093/gbe/evaf094
🖌️ Miriam Merenciano
#genome #TEsky
June 11, 2025 at 10:47 AM
Our recent article on transposable elements and aging - which made the June cover - is the focus of a new Highlight.
"Highlight: 'Jumping Genes' Caught in an Aging Merry-Go-Round"
🔗 doi.org/10.1093/gbe/evaf094
🖌️ Miriam Merenciano
#genome #TEsky
"Highlight: 'Jumping Genes' Caught in an Aging Merry-Go-Round"
🔗 doi.org/10.1093/gbe/evaf094
🖌️ Miriam Merenciano
#genome #TEsky
Reposted by Antony Rod. Lab
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:01 AM
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
Reposted by Antony Rod. Lab
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
May 23, 2025 at 7:23 PM
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Reposted by Antony Rod. Lab
Our work on lineage tracing with somatic epimutations is finally out in @nature.com!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 4:06 PM
Our work on lineage tracing with somatic epimutations is finally out in @nature.com!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Reposted by Antony Rod. Lab
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
May 21, 2025 at 5:17 PM
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
Reposted by Antony Rod. Lab
Congrats @micrornax.bsky.social on this study on let7 in lung injury/repair and thanks for including us as collaborators!
(1/n) Our article is out in @natcomms.bsky.social! We set out to examine the contribution of the ancient Let-7 microRNA over alveolar type 2 (AT2) stem cell plasticity in the genesis of pulmonary injury and interstitial lung disease i work led by Matthew and Shafiq in my lab.
Paper: rdcu.be/elun3
Paper: rdcu.be/elun3
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis
Nature Communications - Loss of let-7, a key microRNA, causes lung alveolar stem cells to grow abnormally and dieprematurely, leading to scarring and lung damage. Here the study links let-7 loss to...
rdcu.be
May 11, 2025 at 8:30 PM
Congrats @micrornax.bsky.social on this study on let7 in lung injury/repair and thanks for including us as collaborators!
(4/n) Probing further with epigenomic experiments we demonstrated that Let-7 controls histone acetylation and methylation of H3K27 to reprogram the formation of profibrotic AT2 stem cells.
May 11, 2025 at 1:41 AM
(4/n) Probing further with epigenomic experiments we demonstrated that Let-7 controls histone acetylation and methylation of H3K27 to reprogram the formation of profibrotic AT2 stem cells.
(3/n) We showed that Let-7 directly controls the expression of an extensive gene regulatory network comprised of transcription factors associated with fibrosis and cancer such as BACH1, EZH2, and MYC to safeguard the lung from scarring.
May 11, 2025 at 1:37 AM
(3/n) We showed that Let-7 directly controls the expression of an extensive gene regulatory network comprised of transcription factors associated with fibrosis and cancer such as BACH1, EZH2, and MYC to safeguard the lung from scarring.
(2/n) We found that Let-7 serves as a molecular guardian of AT2 cells and prevents their abnormal growth and “transformation” into fibrotic scar forming KRT8+ transitional cells in pulmonary fibrosis.
May 11, 2025 at 1:34 AM
(2/n) We found that Let-7 serves as a molecular guardian of AT2 cells and prevents their abnormal growth and “transformation” into fibrotic scar forming KRT8+ transitional cells in pulmonary fibrosis.
(1/n) Our article is out in @natcomms.bsky.social! We set out to examine the contribution of the ancient Let-7 microRNA over alveolar type 2 (AT2) stem cell plasticity in the genesis of pulmonary injury and interstitial lung disease i work led by Matthew and Shafiq in my lab.
Paper: rdcu.be/elun3
Paper: rdcu.be/elun3
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis
Nature Communications - Loss of let-7, a key microRNA, causes lung alveolar stem cells to grow abnormally and dieprematurely, leading to scarring and lung damage. Here the study links let-7 loss to...
rdcu.be
May 11, 2025 at 1:30 AM
(1/n) Our article is out in @natcomms.bsky.social! We set out to examine the contribution of the ancient Let-7 microRNA over alveolar type 2 (AT2) stem cell plasticity in the genesis of pulmonary injury and interstitial lung disease i work led by Matthew and Shafiq in my lab.
Paper: rdcu.be/elun3
Paper: rdcu.be/elun3
Reposted by Antony Rod. Lab
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
go.nature.com
February 25, 2025 at 9:53 PM
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Reposted by Antony Rod. Lab
Look up the impact of NIH funding in your state: www.unitedformedicalresearch.org/nih-in-your-...
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
www.unitedformedicalresearch.org
February 8, 2025 at 10:04 AM
Look up the impact of NIH funding in your state: www.unitedformedicalresearch.org/nih-in-your-...
Reposted by Antony Rod. Lab
Can’t wait for RNA2025! Chairing a new Education session… more details soon!
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
December 19, 2024 at 12:13 AM
Can’t wait for RNA2025! Chairing a new Education session… more details soon!
Reposted by Antony Rod. Lab
An early holiday present from the @MorriseyLab! A story of stem cell collision/competition driving lung regeneration. A tour de force by Dakota…#WhyWeScience!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this “stem cell collision” generates an injury-induced ti...
www.science.org
December 13, 2024 at 12:52 AM
An early holiday present from the @MorriseyLab! A story of stem cell collision/competition driving lung regeneration. A tour de force by Dakota…#WhyWeScience!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Antony Rod. Lab
Our annual Dance Your Ph.D. contest is open for submissions until March 28 💃
The entry form is here (plus more details in the article linked below): www.science.org/content/page...
The entry form is here (plus more details in the article linked below): www.science.org/content/page...
Can you explain your doctoral research through interpretive dance?
The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e
The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e
Science’s ‘Dance Your Ph.D.’ contest is open again!
This year’s competition has a special category on artificial intelligence research or quantum science—no Ph.D. needed
scim.ag
December 5, 2024 at 7:07 PM
Our annual Dance Your Ph.D. contest is open for submissions until March 28 💃
The entry form is here (plus more details in the article linked below): www.science.org/content/page...
The entry form is here (plus more details in the article linked below): www.science.org/content/page...
Reposted by Antony Rod. Lab
I'm really excited to see Prisca's work highlighted here @yegracechen.bsky.social!
I'm thrilled to be included in this Technology Feature with some giants in the circRNA field!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Circular logic: understanding RNA’s strangest form yet
Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care.
www.nature.com
December 5, 2024 at 11:37 AM
I'm really excited to see Prisca's work highlighted here @yegracechen.bsky.social!
Reposted by Antony Rod. Lab
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
Reposted by Antony Rod. Lab
Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...
A modular platform for bioluminescent RNA tracking - Nature Communications
Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...
www.nature.com
December 2, 2024 at 11:54 PM
Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...
Reposted by Antony Rod. Lab
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
December 1, 2024 at 12:30 PM
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.