Meier Lab ICR
@meierlabicr.bsky.social
Cell Death and Immunity Laboratory. We are interested in the mechanisms of #Apoptosis, #Necroptosis and #Inflammation in #Cancer. Posts by @ttenev.bsky.social
Reposted by Meier Lab ICR
We're looking for a Scientific Operations Project Manager
to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...
to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...
Scientific Operations Project Manager in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Operations Project Manager vacancy in Chelsea .
Salary : Commencement on the salary range is subject to comparable skills and experience. Future p...
jobs.icr.ac.uk
April 25, 2025 at 9:49 PM
We're looking for a Scientific Operations Project Manager
to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...
to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...
Reposted by Meier Lab ICR
www.bbc.co.uk/news/article.... Excellent news for breast cancer patients, based on great work from ICR scientists including our own Nick Turner.
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.co.uk
April 11, 2025 at 5:35 AM
www.bbc.co.uk/news/article.... Excellent news for breast cancer patients, based on great work from ICR scientists including our own Nick Turner.
Reposted by Meier Lab ICR
NEWS: NICE has recommended capivasertib for advanced #BreastCancer.
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
April 11, 2025 at 6:37 AM
NEWS: NICE has recommended capivasertib for advanced #BreastCancer.
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
Reposted by Meier Lab ICR
We have a great lineup and many short talk opportunities! Come join us in Suzhou!
February 15, 2025 at 2:34 AM
We have a great lineup and many short talk opportunities! Come join us in Suzhou!
It was pleasure to welcome @francischan.bsky.social at the @icr.ac.uk today. Great talk about the latest work on cell death in maintaining normal tissue homeostasis and disease. Followed by brainstorming white board discussion.
April 3, 2025 at 9:22 PM
It was pleasure to welcome @francischan.bsky.social at the @icr.ac.uk today. Great talk about the latest work on cell death in maintaining normal tissue homeostasis and disease. Followed by brainstorming white board discussion.
Reposted by Meier Lab ICR
We’re hiring! Fancy working on cutting edge mouse models and single cell and spatial phenotyping to understand the evolution of therapy resistance in breast cancer? Join us! jobs.icr.ac.uk/vacancies/11...
Postdoctoral Training Fellow - Functional Genomics in Chelsea | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Functional Genomics vacancy in Chelsea .
Salary: £45,600 - £49,350 p.a. inclusive dependent o n relevant Postdoctoral...
jobs.icr.ac.uk
March 7, 2025 at 9:13 PM
We’re hiring! Fancy working on cutting edge mouse models and single cell and spatial phenotyping to understand the evolution of therapy resistance in breast cancer? Join us! jobs.icr.ac.uk/vacancies/11...
@asharpmedonc.bsky.social gave an excellent discussion on #prostate cancer, highlighting unanswered biological questions and treatment challenges, during our Whiteboard Meeting.
February 19, 2025 at 10:35 PM
@asharpmedonc.bsky.social gave an excellent discussion on #prostate cancer, highlighting unanswered biological questions and treatment challenges, during our Whiteboard Meeting.
Reposted by Meier Lab ICR
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
February 18, 2025 at 4:46 AM
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
Reposted by Meier Lab ICR
For cancer biologists looking for a change of scene, job, or even country… we are advertising for someone to head up our Centre for Target Validation and bring through new cancer drug targets:
jobs.icr.ac.uk/vacancies/47...
Based on our campus in Sutton, south London
jobs.icr.ac.uk/vacancies/47...
Based on our campus in Sutton, south London
Head of Biology and Director, Centre for Target Validation (Group Leader) in Sutton | The Institute of Cancer Research
View details and apply for this Head of Biology and Director, Centre for Target Validation (Group Leader) vacancy in Sutton. Competitive Starting Salary
Tenure : Appointments will be mad...
jobs.icr.ac.uk
February 4, 2025 at 8:40 PM
For cancer biologists looking for a change of scene, job, or even country… we are advertising for someone to head up our Centre for Target Validation and bring through new cancer drug targets:
jobs.icr.ac.uk/vacancies/47...
Based on our campus in Sutton, south London
jobs.icr.ac.uk/vacancies/47...
Based on our campus in Sutton, south London
Reposted by Meier Lab ICR
Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
January 31, 2025 at 6:25 PM
Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲
go.bsky.app/TdKYuS7
Reposted by Meier Lab ICR
On the migration of the scientific community to Bluesky:
www.nature.com/articles/d41... 🧪
www.nature.com/articles/d41... 🧪
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
www.nature.com
January 27, 2025 at 8:19 PM
On the migration of the scientific community to Bluesky:
www.nature.com/articles/d41... 🧪
www.nature.com/articles/d41... 🧪
Reposted by Meier Lab ICR
Reposted by Meier Lab ICR
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8
and GSDMD activation in murine macrophages; however, how macrophages defend against
Yersinia when caspase-8 or YopJ ...
www.cell.com
January 16, 2025 at 11:09 PM
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
Reposted by Meier Lab ICR
🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️
Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky
go.bsky.app/EGXU5V1
Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky
go.bsky.app/EGXU5V1
December 16, 2024 at 11:52 AM
🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️
Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky
go.bsky.app/EGXU5V1
Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky
go.bsky.app/EGXU5V1
Congratulations Crescens and well done for passing your PhD viva with flying colours! Great work between @icrlondon.bsky.social and Royal Marsden Hospital. 👏
January 16, 2025 at 5:56 PM
Congratulations Crescens and well done for passing your PhD viva with flying colours! Great work between @icrlondon.bsky.social and Royal Marsden Hospital. 👏
Reposted by Meier Lab ICR
Exonization of transposons leads to the formation of new protein-coding sequences, potentially impacting immune regulatory pathways.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Transposon exonization generates new protein-coding sequences
In a recent issue of Cell, Arribas et al. and Pasquesi et al. explore the phenomenon of transposable element (TE) exonization and its impact on proteomic and immune diversity, highlighting its potential role as a driver of evolutionary innovation.
www.cell.com
January 6, 2025 at 10:50 PM
Exonization of transposons leads to the formation of new protein-coding sequences, potentially impacting immune regulatory pathways.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Meier Lab ICR
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
January 4, 2025 at 12:34 AM
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
Reposted by Meier Lab ICR
☕This year, in our #CellDeath focus:
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology
Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...
www.nature.com
December 29, 2024 at 6:59 PM
☕This year, in our #CellDeath focus:
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Reposted by Meier Lab ICR
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Meier Lab ICR
Hi Bluesky community! 👋
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
December 13, 2024 at 9:06 AM
Hi Bluesky community! 👋
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Happy holidays from the Meier lab! Thank you everyone from the team! We are so proud and lucky to have such talented and wonderful group of scientists.
December 19, 2024 at 8:29 AM
Happy holidays from the Meier lab! Thank you everyone from the team! We are so proud and lucky to have such talented and wonderful group of scientists.
Reposted by Meier Lab ICR
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 5, 2024 at 4:55 PM
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Reposted by Meier Lab ICR
We are offering a very exciting PhD project 🤩-Project 2- in this great training program!
@icrlondon.bsky.social @imperialcollegeldn.bsky.social
@crukconvergence.bsky.social
Please share 😊 ! Design of advanced therapeutics against metastasis👇
www.convergencesciencecentre.ac.uk/training/con...
@icrlondon.bsky.social @imperialcollegeldn.bsky.social
@crukconvergence.bsky.social
Please share 😊 ! Design of advanced therapeutics against metastasis👇
www.convergencesciencecentre.ac.uk/training/con...
Convergence science PhD - Black in Cancer Students
www.convergencesciencecentre.ac.uk
December 4, 2024 at 9:27 AM
We are offering a very exciting PhD project 🤩-Project 2- in this great training program!
@icrlondon.bsky.social @imperialcollegeldn.bsky.social
@crukconvergence.bsky.social
Please share 😊 ! Design of advanced therapeutics against metastasis👇
www.convergencesciencecentre.ac.uk/training/con...
@icrlondon.bsky.social @imperialcollegeldn.bsky.social
@crukconvergence.bsky.social
Please share 😊 ! Design of advanced therapeutics against metastasis👇
www.convergencesciencecentre.ac.uk/training/con...
This will be the largest broad-spectrum cancer conference in the UK next year.
bacr.org.uk/event/bacr-6...
SAVE THE DATE! | BACR - The British Association for Cancer Research
bacr.org.uk
December 2, 2024 at 11:17 PM
This will be the largest broad-spectrum cancer conference in the UK next year.
bacr.org.uk/event/bacr-6...
Reposted by Meier Lab ICR
Blocking IRE1α enables RNA accumulation, triggering ZBP1-driven cell death and making cold TNBC tumors ICI-sensitive!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer
Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive.
This study reports that immunologically cold triple-negative breast cancer (TNBC)
hijacks an ancient ER stress resp...
www.cell.com
November 26, 2024 at 5:50 PM
Blocking IRE1α enables RNA accumulation, triggering ZBP1-driven cell death and making cold TNBC tumors ICI-sensitive!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...